Network Member Profile
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Dr Carol Wicking
Department:
Institute for Molecular Biosciences
Organisation:
University of Queensland
Address:
Brisbane QLD 4072
Telephone: 07 3346 2052 Facsimile:
07 3346 2101
Email:
c.wicking@imb.uq.edu.au
Web
Address
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Current Field of Study
- Craniofacial and limb development
- Hedgehog signalling in development and disease
Australian Collaborators
- Prof Brandon Wainwright, IMB, UQ
- Prof Rob Parton, IMB, UQ
- Dr Rohan Teasdale, IMB, UQ
- Dr Peter Currie, Victor Chang Cardiac Research Institute
International Collaborators
- Dr CC Hui, Hospital for Sick Kids, Toronto, Canada
- Dr Joy Richman, The University of British Columbia, Vancouver, Canada
- Dr Andrew Lidral, University of Iowa, USA
Facilities
- SRC Microarray facility
- Confocal and Electron Microscopy facilities
Lab Members
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Dr Carol Wicking
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Head of the Lab
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Dr Fiona Simpson
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Senior Research Officer
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| Ms Vicki Metzis |
Research Assistant |
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Ms Natalie Butterfield
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PhD Student
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Mr Liam Town
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PhD Student
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Recent Grant Income
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Description
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CIs
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Type of Grant
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Year
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Income p.a.
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| Hedgehog signaling in limb and craniofacial
development and disease. |
Wicking, C.A., Simpson, F. and Richman, J. |
NHMRC Project Grant |
2006-2008 |
$159,250 |
| NHMRC Senior Research Fellowship |
C.A. Wicking |
NHMRC Fellowship |
2002-2006 |
$ 95,000 |
| Regulation of hedgehog signalling through
intracellular trafficking events |
C.A. Wicking |
NHMRC Project Grant |
2003-2005 |
$ 70,000 |
Recent Publications
Hollway, G.E., Maule, J., Gautier, P., Evans, T.M., Jacoby, A., Keenan, D.G.,
Lohs, C., Fischer, D., Wicking, C. and Currie, P.D. (2006) Scube2 regulates
Hedgehog signaling within the zebrafish embryo. Dev. Biol. 294,104-118.
Bennetts, J.S., Fowles, L.F., Berkman, J.L., Lammerts van Bueren, K., Richman,
J.M., Simpson, F. and Wicking, C. (2006) Evolutionary conservation and murine
embryonic expression of the gene encoding the SERTA domain-containing protein
CDCA4 (HEPP). Gene 374, 153-165.
Wicking, C.A. and Evans, T. (2006) Hedgehog Signalling. In: Ganten, D and Ruckpaul,
K. (eds.) Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine.
Springer, Berlin Heidelberg New York.
Evans, T.M. and Wicking, C. (2006) Rab23. AfCS-Nature Molecule Pages. (doi.1038/mp.a001974.01)
http://www.signaling-gateway.org/
Bennetts, J.S., Fowles, L.F., Butterfield, N.C., Berkman, J.L., Teasdale, R.D.,
Simpson, F. and Wicking, C. (2006) Identification and analysis of novel genes
expressed in the mouse embryonic facial primordia. Frontiers in Bioscience 11,
2631-2646.
Simpson, F., Lammerts van Bueren, K., Butterfield, N., Bennetts, J.S., Bowles,
J., Adolphe, C., Simms, L.A., Young, J, Walsh, M.D., Leggett, B., Fowles, L.,
and Wicking, C. (2006) The PCNA-associated factor KIAA0101/p15PAF binds the
potential tumour suppressor product p33ING1b. Experimental Cell Research 312,
73-85.
Wicking, C.A. and Evans, T. (2006) Hedgehog Signalling. In: Ganten, D and Ruckpaul,
K. (eds.) Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine.
Springer, Berlin Heidelberg New York (in press).
Simpson, F., Martin, S., Evans, T., Kerr, M., James, D.E., Parton, R.G., Teasdale,
R.D. and Wicking, C. (2005) A novel Hook-related protein family and the characterisation
of Hook-related protein 1. Traffic 6, 442-458.
McGlinn, E., Lammerts van Bueren, K., Fiorenza, S., Mo, R., Poh, A., Forrest,
A., Soares, M.B., Bonaldo, M., Grimmond, S., Hui, C.C., Wainwright, B. and Wicking,
C. (2005) Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development.
Mechanisms of Development 122, 1218-1233.
Marsh, A., Wicking, C., Wainwright, B. and Chenevix-Trench G. (2005) Denaturing
high performance liquid chromatography analysis of patients with nevoid basal
cell carcinoma syndrome reveals novel PTCH missense mutations in the sterol-sensing
domain. Human Mutation 26, 283.
Evans, T.M., Simpson, F., Parton, R.G. and Wicking, C. (2005) Characterization
of Rab23, a negative regulator of Sonic hedgehog signalling. Chapter 66, In
: Balch, Der, Hall (eds.) Methods in Enzymology Volume 403, GTPases Regulating
membrane Targeting and Fusion.
Kerr, M.C., Bennetts, J.S., Simpson, F., Thomas, E.C., Flegg, C., Gleeson,
P.A., Wicking C. and Teasdale R.D. (2005) A novel mammalian retromer component,
Vps26B. Traffic 6, 991-1001.
Lalonde JP, Lim R, Ingley E, Tilbrook PA, Thompson MJ, McCulloch R, Beaumont
JG, Wicking C, Eyre HJ, Sutherland GR, Howe K, Solomon E, Williams JH, Klinken
SP. (2004) HLS5, a novel RBCC family member isolated from a hemopoietic lineage
switch, is a candidate tumour suppressor. J. Biol. Chem. 279, 8181-8189.
Smyth, I., Ellis, T., Hetherington, R., Riley, E., Narang, M., Mahony, D.,
Wicking, C., Rothnagel, J.A. and Wainwright, B.J. (2004) Krt6a-cre transgenic
mice direct LoxP-mediated recombination to the companion cell layer of the hair
follicle and following induction by retoic acid to the interfollicular epidermis.
J. Invest. Dermatol. 122, 232-234.
Hime, G.R., Lada, H, Fietz, M.J., Gillies, S, Passmore, A., Wicking, C. and
Wainwright, B.J. (2004) Functional analysis in Drosophila indicates that the
NBCCS/PTCH1 mutation G509V results in activation of Smoothened through a dominant-negative
mechanism. Dev. Dyn., 229, 780-790.
Adolphe, C., Narang, M., Ellis, T., Wicking, C., Kaur, P. and Wainwright, B.J.
(2004) An in vivo comparative study of Sonic, Desert and Indian Hedgehog reveals
that Hedgehog pathway activity regulates epidermal stem cell maintenance. Development
131, 5009-5019.
Fowles, L.F., Bennetts, J.S., Berkman, J.L., Williams, E., Koopman, P., Teasdale,
R.D. and Wicking, C. (2003) Genomic screen for genes involved in mammalian craniofacial
development. genesis 35, 73-87.
Ellis, T., Smyth, I., Riley, E., Graham, S., Elliot, K., Narang, M., Kay, G.F.,
Wicking, C. and Wainwright, B. (2003) A Patched1 conditional null allele in
mice. genesis 36, 158-161.
Ellis, T., Smyth, I., Riley E., Bowles, J., Adolphe, C, Rothnagel, J.A., Wicking,
C. and Wainwright, B.J. (2003) Overexpression of Sonic Hedgehog suppresses embryonic
hair follicle morphogenesis. Dev. Biol. 263, 203-215.
Evans, T.M., Ferguson, C., Wainwright, B.J., Parton, R.G. and Wicking, C. (2003)
Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane
and the endocytic pathway. Traffic 4, 869-884.
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