Network Member Profile
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Associate Profesor Murray Whitelaw
Department:
School of Molecular and Biomedical Sciences, ARC Special Research Centre for the Molecular Genetics of Development
Organisation:
University of Adelaide
Address:
Adelaide SA 5005
Telephone: 08 8303
4724 Facsimile:
08 8303
4348
Email: murray.whitelaw@adelaide.edu.au
Web
Address
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Current Field of Study
- Roles of bHLH/PAS transcription factors in early development and homeostasis
Australian Collaborators
- Prof Jeff Gorman, Institute of Molecular Bioscience, Brisbane, QLD
- Dr Daniel Peet, University of Adelaide, SA
International Collaborators
- Prof Lorenz Poellinger, Karolinska Institute, Stockholm, Sweden
Facilities
- Drosophila and Zebrafish facilities
- Microarray
Lab Members
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A/Prof Murray Whitelaw
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Head of the Lab
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Dr Anne Chapman-Smith
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Research Fellow
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| Mrs Colleen Bindloss |
Research Officer |
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Ms Alexandra Farrall
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PhD Student
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Ms Anne Raimondo
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PhD Student
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Ms Fiona Whelan
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PhD Student
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| Mr David Bersten |
PhD Student |
| Nan Hao |
Honours Student 2007 |
Recent Grant Income
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Description
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Type of Grant
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Year
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Income p.a.
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| Deciphering posttranslational codes in the dioxin receptor
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NHMRC Project Grant |
2007-2009 |
$170,000 |
| The bHLH/PAS transcription factors: Determinants of dimerisation
specificity and high affinity DNA binding. |
ARC Discovery |
2005-2007 |
$90,000
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Recent Publications
Chapman-Smith, A. and Whitelaw, M.L. (2006) Novel DNA binding by a basic helix-loop-helix
protein: The role of the dioxin receptor pas domain. J. Biol. Chem. 281, 12535-45
Bracken, C.P., Fedele, A.O., Linke, S., Balrak, W., Lisy, K., Whitelaw, M.L.
and Peet, D.J. (2006) Cell-specific regulation of HIF-1alpha and HIF-2alpha
: Stabilisation and transactivation in a graded oxygen environment. J. Biol.
Chem. 281, 22575-85
Bracken, C.P., Whitelaw, M.L., and Peet, D.J. (2005) Activity of hypoxia-inducible
factor 2 alpha (HIF-2 alpha) is regulated by association with the NF-kappa B
essential modulator (NEMO / IKK gamma) J. Biol. Chem., 280, 14240-14251.
Chapman-Smith, A., Lutwyche, J.K., Whitelaw, M.L. (2004) Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators. The Journal of Biological Chemistry 279: 5353-62
Kewley, R.J., Whitelaw, M.L., Chapman-Smith, A. (2004) The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. The International Journal of Biochemistry and Cell Biology 36: 189-204
Linke, S., Stojkoski, c., Kewley, R.J., Booker, G.W., Whitelaw, M.L., Peet, D.J. (2004) Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry 279: 14391-7
Peet, D.J., Lando, D., Whelan, D.A., Whitelaw, M.L., Gorman, J.J. (2004) Oxygen-dependent asparagine hydroxylation. Methods in Enzymology 381: 467-87
Lando, D., Gorman, J.J., Whitelaw, M.L. and Peet, D.J. (2003) Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation. Eur. J. Biochem. 270, 1-10
Bracken, C.P., Whitelaw, M.L. and Peet, D.J. (2003) The Hypoxia-Inducible Factors: key transcriptional regulators of hypoxic response. Cell. Mol. Life Sci. 60, 1-18
Lees, M.J., Peet, D.J. and Whitelaw, M.L. (2003) Defining the role of XAP2 in stabilisation of the dioxin receptor. J. Biol. Chem. 278(38):35878-88
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