Network Member Profile
|
|
Professor Emma Whitelaw
Department:
Population Studies and Human Genetics
Organisation:
Queensland Institute of Medical Research
Address:
PO Royal Brisbane Hospital, Queensland 4029
Telephone: 07 3845 3600 Facsimile:
Email: emma.whitelaw@qimr.edu.au
Web
Address
|
Current Field of Study
- Epigenetics and mammalian gene expression
Australian Collaborators
- Dr Chris O'Neill, Royal North Shore Hospital, University of Sydney, Sydney, NSW
- Prof. Nick Martin, National Institute of Medical Research, Brisbane, Qld
- Dr John Rasko, Centenary Institute, University of Sydney, Sydney, NSW
International Collaborators
- Dr. Andras Paldi, Institut Jacques-Monod, CNRS, Universités Paris, Paris, France
- Dr. Haruhiko Koseki, Chiba University, Chiba, Japan
- Dr. Steven Fiering, Dartmouth Medical School, Dartmouth, USA
- Dr. Ruth Arkell, Mammalian Genetics Unit, MRC, Harwell, UK
- Dr. Hester Kroes, University Medical Center, Utrecht, The Netherlands
- Dr. Hans-H. Ropers, Max-Plank Institute, Berlin, Germany
- Dr. En Li, Harvard Medical School, Boston, USA
Facilities
- Flow cytometry facilities
- Transgenic mouse facilities including animal house
- Differential display techniques for identification of variably expressed genes
Lab Members
|
|
Prof Emma Whitelaw
|
Head of the Lab
|
|
Dr Suyinn Chong
|
Postdoctoral Fellow
|
|
Dr Neil Youngson
|
Postdoctoral Fellow
|
|
Ms Alyson Ashe
|
PhD Student
|
|
Mr Tim Bruxner
|
PhD Student
|
|
Mr Daniel Morgan
|
PhD Student
|
| Ms Nadia Whitelaw |
PhD Student |
Recent Grant Income
|
|
Description
|
CIs
|
Type of Grant
|
Year
|
Income p.a.
|
| A role for epigenetic modifiers in maintaining chromosome
integrity during passage through the male gamete in the mouse |
Emma Whitelaw and David de Kretser |
NHMRC Project Grant |
2006-2008 |
$380,000 |
| Identification of variably expressed genes in isogenic mice
and humans |
Emma Whitelaw |
NHMRC Project Grant |
2005-2007 |
$100,000 |
| Epigenetic inheritance through meiosis at the agouti locus
in mice |
Emma Whitelaw |
NHMRC Project Grant |
2003-2006 |
$60,000 |
| Variable expressivity and epigenetic inheritance at the
Axin fused locus in the mouse |
Emma Whitelaw |
NHMRC Project Grant |
2003-2006 |
$80,000 |
| Identification of variably expressed genes in isogenic mice
and humans |
Emma Whitelaw |
NHMRC Project Grant |
2005-2008 |
$100,000 |
A random mutagenesis screen to identify modifiers of epigenetic
phenomena in the
mouse |
Emma Whitelaw |
NHMRC Project Grant |
2004-2008 |
$660,000 (TOTAL) |
| Does developmental noise have an epigenetic basis? |
S. Chong and E. Whitelaw |
ARC Discovery Project Grant |
2004-2006 |
$225,000 (TOTAL) |
Recent Publications
Ashe A and Whitelaw E (2007) Another role for RNA: a messenger across generations.
Trends in Genetics (in press) Review
Whitelaw NC and Whitelaw E (2006) How lifetimes shape epigenotype both within
and across generations. Human Molecular Genetics 2006 Oct: 15 Suppl 2 R131-7
Review
Oates N, van Vliet J, Duffy D, Kroes H, Martin N, Boomsma D, Campbell M, Coulthard
M, Whitelaw E and Chong S (2006). Increased DNA methylation at the AXIN1 gene
in an MZ twin from a pair discordant for a caudal duplication anomaly. American
Journal of Human Genetics, 79, 155-162
Blewitt M, Vickaryous N, Paldi A, Koseki H and Whitelaw E (2006) Dynamic reprogramming
of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genetics,
2, e49
Peaston A and Whitelaw E (2006) Epigenetics and phenotypic variation in mammals.
Mammalian Genome , 17, 365-374 (IF 2)
Whitelaw, E. (2005) Sins of the fathers, and their fathers.European Journal
of Human Genetics , 14, 131-132
Blewitt M, Vickaryous N, Hemley S, Preis J, Ashe A, Bruxner T, Arkell R and
Whitelaw E (2005) An ENU screen for genes involved in variegation in the mouse,
Proc.Natl. Acad.Sci. USA, 102, 7629-34 (IF 11)
Vickaryous N and Whitelaw E (2005) The role of early embryonic environmemt
on epigenotype and phenotype. Reproduction, Fertility and Development 17, 1-6
Chong S, Whitelaw E. (2004) Epigenetic germline inheritance. Curr Opin Genet
Dev. 2004 Dec;14(6):692-6.
Druker R, Bruxner TJ, Lehrbach NJ, Whitelaw E. (2004) Complex patterns of
transcription at the insertion site of a retrotransposon in the mouse. Nucleic
Acids Res. 2004 Nov 01;32(19):5800-8. Print 2004.
Blewitt ME, Chong S, Whitelaw E. (2004) How the mouse got its spots. Trends
Genet. 2004 Nov;20(11):550-4.
Druker R, Whitelaw E. (2004) Retrotransposon-derived elements in the mammalian
genome: a potential source of disease. J Inherit Metab Dis. 2004;27(3):319-30.
Review.
Rakyan VK, and Whitelaw E (2003) Transgenerational epigenetic inheritance.
A Quick Guide, Current Biology, 13 (1):R6
Rakyan V , Chong S, Champ M, Cuthbert P, Morgan H, Luu K and Whitelaw E (2003)
Transgenerational inheritance of epigenetic states at the murine Axin FU
allele occurs after maternal and paternal transmission. Proc.Nat.Acad.Sci. USA,
100(5):2538-2543
Preis J, Downes M, Rasko J, Oates NA, and Whitelaw E (2003) Sensitive flow-cytometric
analysis reveals a novel type of parent-of-origin effect in the mouse genome.
Current Biology 13:955-959
Rakyan VK, Blewitt ME, Druker R, Preis JI, and Whitelaw E (2002) Metastable
epialleles in mammals. Trends in Genetics 18:348-51
Rakyan VK, Preis J, Morgan HD, Whitelaw E. (2001) The marks, mechanisms and
memory of epigenetic states in mammals. Biochem J. 356(Pt 1):1-10.
|
