Network Member Profile
|
|
Dr David Walker
Department: Physiology
Organisation: Monash University
Address: Room 131, Building 13F,
Clayton, VIC 3800
Telephone: 03
9905 2534 Facsimile:
03
9905 2547
Email:david.walker@med.monash.edu.au
Web
Address
|
Current Field of Study
- Fetal and Neonatal Physiology
Australian Collaborators
- Prof Stephen Back, Department of Pediatrics, Oregon Health Sciences University, Portland, OR., USA
- Dr Kate Dzeigielweska, Department of Pharmacology, Melbourne University, Melbourne, Victoria.
- A/Prof Euan Wallace, Department of Obstetrics & Gynaecology, Monash Medical Centre, Clayton, Vic.
- Prof Adrian Walker, Ritchie Centre for Baby Health, Monash Medical Centre, Clayton, Vic
- A/Prof George Smythe, Biomedical Mass Spectrometry Facility, Uni NSW, Sydney, NSW
- Dr David Phillips, Inst. Reproduction & Development, Monash Medical Centre, Clayton, Vic.
- Dr Gilles Guillemin, Centre for Immunology, St Vincent's Hospital, Sydney, NSW.
- Dr Jan West, Department of Biological Sciences, Deakin University, Burwood, Vic.
International Collaborators
Facilities
- Mouse Transgenic facility (“Mouseworks”)
- Spiny Mouse (Acomys caharinis) colony
- HPLC Assay Facilities
Lab Members
|
|
Dr David Walker
|
Head of the Lab
|
|
Dr Edwin Yan
|
Research Officer
|
|
Dr Suzanne Miller
|
Research Fellow
|
|
Dr Margie Castillo-Melendez
|
Research Officer
|
|
Ms Lisa Hutton
|
PhD Student
|
|
Ms Hayley Dickinson
|
PhD Student
|
|
Ms Bobbi Slattery
|
PhD Student
|
|
Ms Tamara Yawno
|
PhD Student
|
|
Dr Ursula Manuelpillai
|
Research Officer
|
Recent Grant Income
|
|
Description
|
CIs
|
Type of Grant
|
Year
|
Income p.a.
|
| The fetal response to infection, with
particular reference to alterations of tryptophan metabolism |
Walker DW, Dzeigielweska K, Smythe GA |
NHMRC Project Grant |
2001-2005 |
$81,035 |
| Essential protective role of neuroactive
steroids in the fetal and neonatal brain |
Hirst JJ, Walker DW |
NHMRC Project Grant |
2001-2003 |
$140,000 |
| Principal Research Fellowship |
Walker DW |
NH&MRC Fellowship |
2001-2005 |
$115,000 |
| Maternal infection and perinatal brain
damage |
Walker DW, Hirst JJ, Phillips DJ, Wallace EM |
March of Dimes Birth Defects Foundation (USA) - project
grant |
2001-2004 |
US $79,863 |
Recent Publications
Nguyen PN, Yan EB, Castillo-Melendez M, Walker DW, Hirst JJ. (2004) Increased
allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion.
J Physiol. 2004 Oct 15;560(Pt 2):593-602. Nguyen PN, Ross Young I, Walker DW,
Hirst JJ. (2004) Allopregnanolone in the brain and blood after disruption of
the hypothalamic-pituitary-adrenal axis in fetal sheep. J Endocrinol. 2004 Jul;182(1):81-8.
Castillo-Melendez M, Chow JA, Walker DW. (2004) Lipid peroxidation, caspase-3
immunoreactivity, and pyknosis in late-gestation fetal sheep brain after umbilical
cord occlusion. Pediatr Res. 2004 May;55(5):864-71.
Manuelpillai U, Nicholls T, Wallace EM, Phillips DJ, Guillemin G, & Walker
DW (2003) Increased mRNA expression of kynurenine pathway enzymes in human placentae
exposed to bacterial endotoxin. Adv. Exp. Biol. &Med. (in press).
Billiards SS, Hirst JJ, Walker DW (2003) Sudden Infant Death: new role for
neurosteroids. Australasian Science 24: 17-18.
Nguyen PN, Billiards SS, Walker DW, Hirst JJ (2003) Changes in 5α-pregnane
steroids and neurosteroidogenic enzyme expression in the perinatal sheep.
Pediatr. Res. (in press).
Craig A, Lou NN, Beardsley DJ, Wingate-Pearse N, Walker DW, Hohimer AR, Back
SA (2003) Timing of oligodendrocyte lineage progression as a measure of cerebral
white matter maturation in rodents versus humans: relevance for definiation
of the vulnerable period in models of white matter injury. Exp. Neurol.
(in press).
Yan E, Castillo-Melendez M, Nicholls T, Hirst JJ, Walker DW (2003) Cerebrovascular
responses in the fetal brain to low dose endotoxin. Pediatr. Res. (accepted
February, subject to minor revision).
Castillo-Melendez M, Chow JA, Walker DW (2003) Distribution of lipid peroxidation,
caspase-3 immunoreactivity and pyknosis in the fetal brain after umbilical cord
occlusion. Pediatr. Res. (accepted, subject to minor revision).
Billiards SS, Walker DW, Canny BJ, Hirst JJ. (2002) Endotoxin increases sleep
and brain allopregnanolone concentrations in newborn lambs. Pediatr Res. 2002
Dec;52(6):892-9.
|
