Network Member Profile
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Dr David Tremethick
Department:
Molecular Biosciences, The John Curtin School of Medical Research
Organisation:
Australian National University
Address:
GPO Box 334, Canberra, ACT 2601
Telephone: 02 61252326 Facsimile:
02 61250415
Email:David.tremethick@anu.edu.au
Web
Address
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Current Field of Study
- Chromatin structure and function
Australian Collaborators
- Prof. Any Choo, Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne
International Collaborators
- Dr. Karolin Luger, Department for Biochemistry and Molecular Biology, Colorado State University, USA
Facilities
- Microarray
- Mass Spec (will be established in 2005)
- Cellular imaging
- Protein biophysics
Lab Members
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Dr David Tremethick
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Head of the Lab
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Dr Danny Rangasamy
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Research Fellow
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Dr Jun Fan
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Research Fellow
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Dr Pat Ridgway
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Research Fellow
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Dr Ian Greaves
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Research Fellow
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Dr Tanya Soboleva
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Postdoc
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Lee Sung Hun
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PhD Student
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Recent Grant Income
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Description
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CIs
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Type of Grant
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Year
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Income p.a.
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| The Dynamic Control of Chromatin Structure. |
1 |
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2007-2009 |
$90,000 |
Chromatin remodelling and transcriptional regulation of CD8
T-cell effector function gene expression
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3 |
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2007-2009 |
$170,000 |
| Mechanisms that underpin chromosome stability 2Cis |
2 |
NHMRC Project Grant |
2006-2008 |
$164,000 |
| Role of Heterochromatin in regulating cellular proliferation
and development. |
1 |
NHMRC Project Grant |
2005-2007 |
$165,000 |
Recent Publications
Jun Y. Fan, Jiansheng Zhou and David J. Tremethick (2007). Quantitative Analysis
of HP1 Binding to Nucleosomal Arrays. Methods 41, 286-290.
Greaves, I.K., Ranagsamy, D., Ridgway, P., and Tremethick D. J. (2007). The
specialised chromatin organization of the centromere requires H2A.Z. Proc. Natl.
Acad. Sci. USA 104, 525-530.
Kylie M. Wagstaff, Dominic J. Glover, David J. Tremethick and David A. Jans
(2007) Histone-mediated-transductions as an efficient means for gene delivery.
Molecular Therapy 15, 721-731.
Tremethick, D.J (2007) Higher-order structures of chromatin: the elusive 30
nm fibre. Cell 128, 651-654.
Bulynko YA, Hsing LC, Mason RW, Tremethick DJ, Grigoryev SA. (2006) Cathepsin
L stabilizes the histone modification landscape on the Y chromosome and pericentromeric
heterochromatin. Mol.Cell.Biol. 26, 4172-84.
Greaves IK, Rangasamy D, Devoy M, Marshall Graves JA, Tremethick DJ. (2006).
The X and Y chromosomes assemble into H2A.Z-containing facultative heterochromatin
following meiosis. Mol. Cell. Biol. 26, 5394-405.
Bruce K, Myers FA, Mantouvalou E, Lefevre P, Greaves I, Bonifer C, Tremethick
DJ, Thorne AW, Crane-Robinson C. (2005) The replacement histone H2A.Z in a hyperacetylated
form is a feature of active genes in the chicken. Nucleic Acids Res. 33, 5633-9
Henderson, A., Holloway, A., Reeves, R., and Tremethick, D.J. (2004) Recruitment
of SWI/SNF to the HIV-1 promoter. Mol.Cell.Biol.24, 389-397.
Ridgway, P., D. Rangasamy, L. Berven, U. Svensson, and D.J. Tremethick, Analysis
of Histone Variant H2A.Z localisation and expression during early development
(2004) Methods in Enzymology375.
Rangasamy, D., Greaves, I., and Tremethick, D. J. (2004) RNA interference demonstrates
a novel role for H2A.Z in chromosome segregation. Nature Struct.and Mol. Biol.
11, 650-655.
Park, Y., Dyer, P.N., Tremethick, D.J. and Luger, K. (2004) A new FRET approach
demonstrates that the histone variant H2AZ stabilizes the histone octamer within
the nucleosome. J. Biol.Chem. 279 , 24274-82.
Bao, Y., Konesky, K., Park, J., Rosu, S., Dyer, P.N., Rangasamy, D., Tremethick,
D. J ., Laybourn, P.J., Luger. K. (2004) Nucleosomes containing the histone
variant H2A.Bbd organize DNA inefficiently. EMBO J 23 , 3314-24.
Ridgway, P., Brown, K.D., Rangasamy, D., Svensson, U., and Tremethick D.J. (2004)
Unique residues on the H2A.Z containing nucleosome surface are important for
Xenopus laevis development. J. Biol. Chem. 279, 43815-43820.
Fan, J.Y., Rangasamy, D., Luger. K., and Tremethick, D.J. (2004) H2A.Z alters
the nucleosome surface to promote HP1 alpha mediated fibre folding. Molecular
Cell 16, 655-661.
Henderson A, Bunce M, Sidden N, Reeves R and Tremethick D (2000) High-Mobility
Group I can modulate Binding of Transcription factors to the V5 Region of the
HIV-1 Provial Promoter. J. Virology 74, 10523-10534.
Suto, R. K., Clarkson, M. J., Tremethick, D. J., and Luger, K. (2000) Crystal
structure of a nucleosome core particle containing the variant H2A.Z. Nature
Struct. Biol. 7, 1121-1124.
Clarkson, M., Wells, J.R.E., Gibson, F., Saint, R. and Tremethick D.J. (1999)
Regions of variant histone His2AvD required for Drosophila development. Nature
300, 694-697.
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