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Network Member Profile

Current Field of Study

• Gonad development and Germ cell regulation

Australian Collaborators

• Prof. Peter Koopman, University of Queensland, Brisbane, QLD.
• A. Prof. Vincent Harley, Prince Henry’s Medical Research Institute, Melbourne, VIC.
• Dr. Kate Loveland, Monash Institute of Medical Research, Melbourne, VIC.
• Dr. Garry Hime, University of Melbourne, Melbourne, VIC.
• Prof. John Aitken, University of Newcastle, Newcastle, NSW.
• Prof. Jenny Graves, Australian National University, Canberra, ACT.

International Collaborators

• Prof. Arthur Arnold, University of California Los Angeles, Los Angeles, CA, USA
• Prof. Eric Vilian, University of California Los Angeles, Los Angeles, CA, USA
• Dr. Ken McElreavey, Pasteur Institute, Paris, France.
• Dr. David Silversides, University of Montreal, Montreal, Canada
• Dr. Garry Berkovitz, University of Miami, Miami, USA.
• Dr. Laslo Orban, Temask life Sciences, Institute, Singapore.
• Dr. Michael Clinton, Roslin Institute, Edinburgh, UK.
• Prof. Kiyoshi Shimada, Univ. Nagoya, Nagoya, Japan.
• Prof Niels Skakkebaek, Copenhagen University Hospital, Denmark

Facilities

• Confocal microscopes
• FACS
• Microarray facility

Recent Publications

1. Western, P.S., Harry, J.L., Graves, J.A.M. and Sinclair, A.H. (2000) Temperature dependent sex determination: the expression of SF1, WT1 and DAX1 during gonadogenesis. Gene 241:223-232

2. Smith, C.A., Clifford, V., Smith, M.J., Western, P.S., Wilcox, S., Bell, K.S. and Sinclair, A.H. (2000) Cloning and expression of DAX-1 in the chick embryo. J. Mol. Endocrinol. 24:23-32

3. O'Neill, M.J., Binder, M.D., Smith, C.A., Reed, K.J., Smith, M.J., Millar, C.D., Lambert D.M. and Sinclair, A.H. (2000) ASW: a gene with conserved avian W-linkage and female specific expression in chick embryonic gonad. Development Genes and Evolution 210:243-249

4. Wilmore, H.P., Smith, M.J., Bell, K.M. and Sinclair, A.H. (2000) SOX14 is a candidate gene for limb defects associated with BPES and Mobius syndrome. Human Genetics 106:269-276

5. Bell, K.M., Western, P.S. and Sinclair, A.H. (2000) SOX8 expression during chick embryogenesis. Mechanisms of Development 94:257-260

6. Andrews, J.E., Shioda, T., O'Neill, M.J., Binder, M.D. and Sinclair, A.H. (2000) Isolation, expression and transcriptional activation of a novel member of the CITED gene family. Mechanisms of Development 95:307-310

7. McClive, P.J. and Sinclair, A.H. (2001) Rapid extraction and PCR-sexing of mouse embryos. Molecular Reproduction and Development 60:225-226

8. Sinclair, A.H. (2001) Eleven years of sexual discovery. Genome Biology 2:40171-40173

9. Western, P.S. and Sinclair, A.H. (2001) Sex, genes and heat: triggers of diversity. J. Exp. Zool. 290:624-631

10. Smith, C.A. and Sinclair, A.H. (2001) Sex determination in the chick embryo. J. Exp. Zool. 290:691-699

11. Reed, K.J. and Sinclair, A.H. (2002) FET-1: a novel W-linked, female specific gene up-regulated in the embryonic chicken ovary. Mechanisms of Development 119S:87-90

12. Smith, C.A., Hurley, T.M., McClive, P.J. and Sinclair, A.H. (2002) Restricted expression of DMRT3 in chicken and mouse embryos. Mechanisms of Development 119S:73-76

13. Morrish, B. C. and Sinclair, A.H. (2002) Vertebrate Sex Determination - many means to an end. Reproduction 124:447-457

14. Smith, C.A., Katz, M. and Sinclair, A.H. (2003) DMRT1 is up-regulated in the gonads during sex reversal in ZW chicken embryos. Biology of Reproduction 68:560-570

15. McClive, P.J and Sinclair, A.H. (2003) Type II and IX collagen isoforms are up-regulated during testis development. Biology of Reproduction 68:1742-1747

16. Sarraj, M., Wilmore, H.P., McClive, P.J. and Sinclair, A.H. (2003) Sox15 is up-regulated in embryonic mouse testis. Gene Expression Patterns 3:413-417

17. Low, Y., Hutson, J.M., Grover, S., Metcalfe, S., Northam, E., Savulescu, J., Sinclair, A.H. and Warne, G. (2003) Rules for clinical diagnosis in babies with ambiguous genitalia. J. Paediatric Child Health 39:406-413

18. McClive, P.J., Hurley, T.M., Sarraj, M.A., van den Bergen, J.A. and Sinclair, A.H. (2003) A subtractive hybridisation screen identifies sexually dimorphic genes in the embryonic mouse testis. Genesis 37:84-90

19. Boyer, A., Lussier, J.G., Sinclair, A.H., McClive, P.J., Silversides, D.W. (2004) Pre-Sertoli specific gene expression profiling reveals differential expression of Ppt1 and Brd3 genes within the mouse genital ridge at the time of sex determination. Biology of Reproduction 71:820-827

20. Hurley, T.M., McClive, P.J., Sarraj, M.A. and Sinclair, A.H. (2004) Eki2, is up-regulated specifically in the testis during mouse sex determination. Gene Expression Patterns 4:135-140

21. Dennis, C. and Sinclair, A.H. (2004) (News commentary) Biomedical research comes up short down under. Nature Medicine. 10:556

22. Smith, C.A and Sinclair, A.H. (2004) Sex determination: insights from the chicken. BioEssays 26:1-13

23. Sarraj, M., McClive, P.J., Wilmore, H.P., Loveland, K.L. and Sinclair, A.H. (2005) A novel scavenger receptor gene, is differentially expressed in the embryonic and adult mouse testis. Developmental Dynamics 234:1026-1033

24. Koopman, P., Browne, C., Jackson, A., Ewen, K., Aitken, R.J., van den Bergen, J., Western, P. and Sinclair, A.H. (2005) Identification and study of genes important for fetal germ cell biology in mice. Reproduction Fertility and Development 16S:21-21

25. Smith, C.A., McClive, P.J., and Sinclair, A.H. (2005) Male specific cell migration into the developing gonads is a conserved process involving PDGF signalling. Developmental Biology 284:337-350

26. Jeanes, A., Wilhelm, D., Wilson, M., McClive, P.J., Sinclair, A.H. and Koopman, P.A. (2005) Markers of the peritubular myoid cell lineage in the developing murine testes. Reproduction 130:509-516

27. Williams, L., McClive, P.J., van den Bergen, J. and Sinclair, A.H. (2005) Expression of annexin XI in the embryonic mouse testis. Developmental Dynamics 234:342-437

28. Hudson, Q., Smith, C.A. and Sinclair, A.H. (2005) Aromatase inhibition reduces expression of FOXL2 in the developing chicken ovary. Developmental Dynamics 233:1052-1055

29. Wilmore, H.P., Smith, C.A., McClive, P.J. and Sinclair, A.H. (2005) The expression profile of the RNA-binding protein gene, hermes, during chicken embryonic development. Developmental Dynamics 233:1045-1051

30. Hudson, Q., Smith, C.A. and Sinclair, A.H. (2005) Conserved expression of a novel gene during gonad development. Developmental Dynamics 233:1083-1090

31. Warne, G.L., Grover, S., Sinclair, A.H., Metcalfe, S., Hutson, J, Northam, E., Freeman, J. and Savulescu, J. (2005) A long-term outcome study of intersex conditions. J. of Paediatric Endocrinology and Metabolism 18:555-568

32. Smith, C.A., McClive, P.J. and Sinclair, A.H. (2005) Temporal and spatial expression of the armadillo-related gene, Alex2, during testicular development in the mouse. Developmental Dynamics 233:188-193

33. Smith, C.A. and Sinclair, A.H. (2005) Molecular genetics of gonadal sex determination. In: Cytogenetics and Genome Research. (Eds. Nanda, I., Schmid, M., Burt, D.) 109:1-87

34. Maldonado-Saldivia, J., van den Bergen, J., Krouskos, M., Gilchrist, M., Sinclair, A.H., Surani, M.A., Western, P.S. (2006) Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line. Stem Cells (in press)

35. Knower, K.C., McClive, P.J., Bowles, J, Koopman, P., Sinclair, A.H. and Harley, V.R. (2006) Expression profile of sexually dimorphic urogenital ridge genes in human embryonic testicular carcinoma line NT2/D1. Sexual Development (in press)

36. Svingen, T., Beverdam, A., Bernard, P., McClive, P.J., Harley, V.R., Sinclair, A.H., and Koopman, P. (2006) Sex-specific expression of a novel gene BC019731 during mouse testis differentiation. (submitted)

37. Sinclair, A.H. and Schofield, P.R. (2006) A blueprint for responsible research on human embryos. Cell (Editor solicited review, in press)

38. Smith, C.A., Roezler, K.N. and Sinclair, A.H. (2006) Avian Sex determination. Cytogenetics and Genome Research. (in press)