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Network Member Profile

Current Field of Study

• Molecular genetics, cell and developmental biology
• Mechanisms of cell division and cell migration

Australian Collaborators

• A/Prof Robert Richards, University of Adelaide, Adelaide, SA
• Dr Stephen Gregory, University of Adelaide, Adelaide, SA
• Dr David Miller and Dr Eldon Ball, Australian National University, Canberra, ACT

International Collaborators

• Dr. Amy Bejsovec, Duke University, USA
• Dr. Barry Dickson, IMP, Vienna, Austria

Facilities

• Use of Drosophila as a model organism- genetics analysis, genetic transformation, gene knockout
• Confocal microscopy
• Deconvolution microscopy
• Live imaging
• Microarray
• Proteomics facilities

Recent Publications

M. Coulson, S. Robert and R. Saint (2005) Drosophila starvin encodes a tissue-specific BAG domain protein required for larval food uptake. Genetics Sep
2; Epub ahead of print.

M. Zavortink1, N. Contreras1, T. Addy, A. Bejsovec, and R. Saint (2005) Tum/RacGAP50C provides a critical link between anaphase microtubules and the
assembly of the contractile ring in Drosophila melanogaster. J. Cell Sci. 118: 5381-5392

U. Technau, S. Rudd, P. Maxwell, P.M.K. Gordon, M. Saina, L. C. Grasso, D.C. Hayward, C.W. Sensen, R. Saint, T.W. Holstein, E.E. Ball, D.J. Miller.
(2005) Maintenance of non-metazoan genes in two basal cnidarians. Trends in Genetics 21: 633-639

L.V. O’Keefe, Y-H. Liu, A. Perkins, S. Dayan, R. Saint and R.I. Richards (2005) FRA16D common chromosomal fragile site oxido-reductase
(FOR/WWOX) protects against the effects of ionizing radiation in Drosophila. Oncogene 24: 6590-6596.

S.L. Gregory, T. Shandala and R. Saint (2005) Regulation of Rho small GTPase signalling during cell division In: Signal Transduction of Cell Division.
pp285-305. T. Miki ed. (Research Signpost, Kerala, India).

Smallhorn, M., Murray M.J., SAINT, R. (2004) The epithelial-mesenchymal transition of the Drosophila mesoderm requires the Rho GTP exchange factor Pebble. Development 131: 2641-51

Shandala, T., Gregory, S.L., Dalton, H.E., Smallhorn, M., SAINT, R. (2004) Citron Kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster. Development 131: 5053-63

Brumby, A., Secombe, J., Horsfield, J., Coombe, M., Amin, N., Coates, D., SAINT, R, Richardson, H. (2004) A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in drosophila. Genetics 168: 227-51

Ball, E.E., Hayward, D.C., SAINT, R., Miller, D.J. (2004) A simple plan - cnidarians and the origins of developmental mechanisms. Nature Reviews Genetics 5: 567-77

D. Kortschak, G. Samuel, R. SAINT and D. Miller (2003) EST analysis of the cnidarian Acropora millepora reveals extensive gene loss and rapid sequence divergence in the model invertebrates. Curr. Biol. accepted for publication

R. SAINT and W.G. Somers (2003) Animal cell division: A fellowship of the double ring? J. Cell Sci. 116: 4277-4281

W.G. Somers and R. SAINT (2003) A RhoGEF and Rho Family GTPase-Activating Protein Complex Links the Contractile Ring to Cortical Microtubules at the Onset of Cytokinesis. Dev. Cell 4: 29-39.
[discussed in minireviews: J. Cell Biol. 160: 627 (2003); Curr. Biol. 13: R363-R365 (2003); Molecular Cell 11: 846-848 (2003)]

T. Shandala, K. Takizawa and R. SAINT (2003) The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNS. Development 130: 1505-1513.

D.C. Hayward, G. Samuel, P.C. Pontynen, J. Catmull, R. SAINT, D.J. Miller, and E.E. Ball (2002) Localised expression of a DPP/BMP2/4 ortholog in a coral embryo. Proc. Natl. Acad. Sci. (USA) 99: 8106-8111.

A. M. Brumby, C. B. Zraly, J. A. Horsfield, J. Secombe, R. SAINT, A. K. Dingwall, and H. Richardson (2002) Drosophila cyclin E interacts with components of the Brahma complex. EMBO J. 21:3377-3389.

E.E. Ball, D.C. Hayward, J.S. Reece-Hoyes, N.R. Hislop, G. Samuel, R. SAINT, P.L. Harrison, and D.J.Miller (2002) Coral Development: from Classical Embryology to Molecular Control. Int. J. Dev. Biol. 46: 671-678.

T. Shandala, D. Kortschak, and R. SAINT (2002) The Drosophila retained/dead ringer gene and ARID gene family function during development. Int. J. Dev. Biol. 46: 423-430.

SAINT, R. (2002) Profile of the Adelaide Centre for the Molecular Genetics of Development. Int. J. Dev. Biol. 46:361-362.

T. Wilanowski, A. Tuckfield L. Cerruti, S. O'Connell, R. SAINT, V. Parekh, J. Tao, J.M. Cunningham and S.M. Jane. (2002) A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead Mech Dev. 114:37-50.

D. Crack, J. Secombe, R. SAINT and H. Richardson. (2002) Analysis of Drosophila Cyclin E I and II proteins during development: The N-terminus of Cyclin E I is sensitive to an inhibitor in the posterior part of the morphogenetic furrow during eye development. Developmental Biology 241:157-71.