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Network Member Profile

Current Field of Study

• Cytokine biology and immunology of early pregnancy and pre-implantation embryo development.

Australian Collaborators

• Professor Geoff Shellam (University of Western Australia, Perth)

International Collaborators

• Professor John Aplin (University of Manchester, Manchester UK)
• Professor Alistair Ramsay (Louisiana State University, USA)
• Associate Professor Matts Wikland (Fertilitetscentrum, Gothenberg, Sweden)
• Dr Kristina Gemzell-Danielsson (Karolinska Hospital, Stockholm, Sweden)

Facilities

• Real time quantitative PCR
• FACS / flow cytometry
• Array of cytokine null mutant mouse models, and transgenic T-cell receptor mouse models
• Tissue & embryo culture facility
• ELISA and cytokine bioassays

Recent Publications

Robertson SA, Skinner RJ, Care AS (2006) Interleukin-10 regulates inflammatory cytokine synthesis to protect against LPS-induced abortion and fetal growth restriction in mice. Biology of Reproduction (accepted for publication, Nov 2006; BIOLREPROD/2006/056143).

Robertson SA (2006) Seminal fluid signalling in the female reproductive tract - lessons from rodents and pigs. Journal of Animal Science (Nov 3; Epub ahead of print)

Jasper MJ, Tremellen KP and Robertson SA (2006) Reduced endometrial IL-6 expression in recurrent miscarriage. Journal of Reproductive Immunology (Oct 9; Epub ahead of print).

Wu R, Fujii S, Ryan NK, Van der Hoek KH, Jasper MJ, Sini I, Robertson SA, Robker RL, Norman RJ (2006) Ovarian leukocyte distribution and cytokine/chemokine mRNA expression in follicular fluid cells in women with polycystic ovary syndrome. Human Reproduction (Sept 22; Epub ahead of print)

Jasper MJ, Tremellen KP and Robertson SA (2006) Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Molecular Human Reproduction 12: 301-8.

O'Leary S, Jasper MJ, Robertson SA and Armstrong DT (2006) Seminal plasma regulates ovarian progesterone production, leukocyte recruitment and follicular cell responses in the pig. Reproduction 132: 147-58.

Robertson SA, O'Leary S, Armstrong DT (2006) Influence of semen on inflammatory modulators of embryo implantation. Reproduction Supplement 62: 231-45.

Robertson SA, Care AS, Skinner RJ (2006) Essential role for interleukin-10 in resistance to LPS-induced preterm labour in mice. Journal of Immunology 177: 4888-96.

Ingman WI, Woittiez K, Robertson SA (2005) Null mutation in TGFb1disrupts ovarian function causing impaired folliculogenesis, oocyte incompetence and early embryo arrest. Endocrinology 147: 835-45.

Robertson SA (2005) Seminal plasma and male factor signalling in the female reproductive tract. Cell and Tissue Research 322:43-52.

Jasper MJ, Tremellen KP and Robertson SA (2005) Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Molecular Human Reproduction (in press).

Robertson SA, O'Leary S and Armstrong DT (2005) Influence of semen on inflammatory modulators of embryo implantation in pigs. In Control of
Pig Reproduction VII; Reproduction Supplement 62 (in press)

White CA, Johansson M, Roberts CT, Ramsay AJ, Robertson SA (2004) Effect of interleukin-10 null mutation on maternal immune response and reproductive outcome in mice. Biology of Reproduction 70:123-31

Johansson M, Bromfield JJ, Jasper MJ, Robertson SA (2004) Semen activates the female immune response during early pregnancy in mice. Immunology 112: 290-300

Hudson-Keenihan SN, Robertson SA (2004) Diversity in phenotype and steroid hormone dependence in dendritic cells and macrophages in the mouse uterus. Biology of Reproduction 70(6): 1562-72

Miyakis S, Robertson SA, Krilis SA (2004) Beta-2 glycoprotein 1 and its role in antiphospholipid syndrome -lessons from knockout mice. Journal of Clinical Immunology 112: 136-43

Robertson SA, Roberts CT, van Beijering E, Pensa K, Sheng Y, Shi T, Krilis SA (2004) Effect of ß2-glycoprotein I null mutation on reproductive outcome and antiphospholipid antibody mediated pregnancy pathology in mice. Molecular Human Reproduction 10: 409-16

O'Leary S, Jasper MJ, Warnes GM, Armstrong DT and Robertson SA (2004) Seminal plasma regulation of endometrial cytokine expression and leukocyte recruitment in the pig. Reproduction 128: 237-47

Gangnuss S, Sutton-McDowall ML, Robertson SA, Armstrong DT (2004) Seminal plasma regulates corpora lutea macrophage populations during early pregnancy in mice. Biology of Reproduction 71: 1135-41.

Robertson SA, Redman CW, McCracken SA, Hunt JS, Dimitriadis E, Moffett-King A and Chamley L. (2003) Immune modulators of implantation and placental development. Trophoblast Research (in press).

Sferruzzi-Perri AN, Robertson SA, Dent LA (2003) Interleukin-5 transgene expression and eosinophilia are associated with retarded mammary gland development in mice. Biology of Reproduction 69:224-33

Ryan NK, Van der Hoek KH, Robertson SA, Norman RJ. (2003) Leptin and leptin receptor expression in the rat ovary. Endocrinology 144:5006-13.

Robertson SA, Bromfield JJ and Tremellen KP (2003) Seminal ‘priming’ for protection from pre-eclampsia - a unifying hypothesis. Journal of Reproductive Immunology 59: 253-65 .

Robertson SA, Hudson SN (2002) Immunobiology; Cytokines. In: S Glasser, J Aplin, L Guidice and S Tabidzadeh (eds.), The Endometrium. Harwood Academic Publishers, London

O’Leary S, Robertson SA, Armstrong DT (2002) The influence of seminal plasma on ovarian function in pigs – a novel inflammatory mechanism Journal of Reproductive Immunology 57, 225-238.

Robertson SA, Ingman WV, O’Leary S, Sharkey D and Tremellen KT (2002) Transforming growth factor b: a mediator of immune deviation in seminal plasma. J Reproductive Immunology 57, 109-128.

Ingman WV and Robertson SA (2002) Defining the actions of transforming growth factor beta in reproduction. Bioessays 24, 904-914.

Thompson JT, Kind K, Roberts CT, Robertson SA and Robinson JS (2002) Epigenetic risks related to assisted reproductive technologies: Short and long-term consequences for the health of children conceived through ART – more reason for caution? Human Reproduction 17:2783-2786.

Sjöblom C, Wikland M, Robertson SA . (2002) Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos. Biology of Reproduction 67:1817-1823.