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Network Member Profile

Current Field of Study

• Developmental haemopoiesis, early murine development, murine models of haematological malignancy

Australian Collaborators

• Dr Patrick Tam, Childrens Medical Research Institute, Sydney, NSW
• Professor Richard Harvey, Victor Chang Cardiac Research Institute, Sydney, NSW
• Dr Lois Salamonsen, Prince Henrys Institute for Medical Research, Melbourne, VIC

International Collaborators

• Dr Joshua Brickman, Institute for Stem Cell Research, University of Edinburgh, United Kingdom

Facilities

• AGRF, high speed flow cytometric cell sorting

Recent Publications

Refereed Journal Articles

Tam PPL, Poh-Lynn Khoo P-L, Lewis SL, Bildsoe H, Wong N, Tsang TE, Gad JM Robb L Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation. Development (in press)

Jenkins BJ, Roberts AW, Greenhill CJ, Najdovska M, Lundgren-May T, Robb L, Grail D, Ernst M.Pathological consequences of STAT3 hyper-activation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis. Blood. (in press)

Bao L, Devi S, Bowen-Shauver J, Ferguson-Gottschall S, Robb L, Gibori G..The role of interleukin-11 in pregnancy involves up-regulation of {alpha}2-macroglobulin gene through jak2-stat3 pathway in the decidua. Mol Endocrinol. (in press)

Glaser S, Metcalf D, Wu L, Hart AH, DiRago L, Mifsud S, D'Amico A, Dagger S, Campo C, Chan AC, Izon DJ, Robb L. Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia. Proc Natl Acad Sci U S A. 103(44):16460-5 2006.

Goschnick MW, Lau LM, Wee JL, Liu YS, Hogarth PM, Robb L, Hickey MJ, Wright MD, Jackson DE. Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice. Blood. 108(6):1911-8 2006.

Forrai A, Boyle K, Hart A, Hartley L, Rakar S, Willson TA, Simpson KM, Roberts AW, Alexander WS, Voss AK, Robb L. (2005) Absence of SOCS3 reduces self-renewal and promotes differentiation in murine embryonic stem cells. Stem Cells. 24, 604-614 2006.

Robb L, Boyle K, Rakar S, Hartley L, Lochland J, Roberts AW, Alexander WS, Metcalf D. Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease. Proc Natl Acad Sci U S A. 102(45):16333-8 2005

Hart AH, Hartley L, Parker K, Ibrahim, M Looijenga L, Chow CW, Robb L. (2005) The pluripotency homeobox gene NANOG is expressed in human germ cell tumors. Cancer. 104(10):2092-8 2005

Hart AH, Willson TA, Wong M, Parker K, Robb L. (2005) Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1. Biochem Biophys Res Commun. 333: 1361-9 2005

Sims NA, Jenkins BJ, Nakamura A, Quinn JM, Li R, Gillespie M, Ernst M, ROBB L, Martin TJ. Interleukin 11 is required for normal bone remodelling J Bone Mineral Research 20: 1093-102 2005

Ng ES, Azzola L, Sourris K, ROBB L, Stanley EG, Elefanty AG. (2005) The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells. Development 132: 873-884 2005

Wong PK, Campbell IK, ROBB L, Wicks IP. (2004) Endogenous IL-11 is pro-inflammatory in acute methylated bovine serum albumin/interleukin-1-induced (mBSA/IL-1) arthritis. Cytokine 21: 72-76 2004

White CA, ROBB L, Salamonsen LA. (2004) Uterine extracellular matrix components are altered during defective decidualization in interleukin-11 receptor alpha deficient mice. Reprod Biol Endocrinol. 10: 76-82 2004

Hart A, Hartley L, Ibrahim M, ROBB L. (2004) Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Dev Dynamics, 230: 187-198 2004

Croker BA, Metcalf D, ROBB L, Wei W, Mifsud S, DiRago L, Cluse LA, Sutherland KD, Hartley L, Williams E, Zhang J-G, Hilton DJ, Nicola NA, Alexander WS, Roberts, A. (2004) SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 20: 153-164 2004

Curtis D, Hall MA, van Stekelenburg LJ, ROBB L, Jane SM, Begley CG. (2004) SCL is required for normal function of hematopoietic stem cells. Blood, 103: 3342-3348 2004

van Eekelen A, Bradley CK, Gothert JR, ROBB L, Elefanty AG, Begley CG, Harvey AR. Expression pattern of the transcription factor SCL in the central nervous system of the embryonic and adult mouse. Neuroscience 122: 421-436 2003

Wong S, McLaughlin J, Cheng D, Shannon K, ROBB L, Witte ON. IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease. Proc Natl Acad Sci. USA, 100: 11630-5 2003

Croker BA, Krebs DL, Zhang JG, Wormald S, Willson TA, Stanley EG, ROBB L, Greenhalgh CJ, Forster I, Clausen BE, Nicola NA, Metcalf D, Hilton DJ, Roberts AW, Alexander WS. SOCS3 negatively regulates IL-6 signaling in vivo. Nature Immunol 6: 540-5 2003.

Dimitriadis E, ROBB L, Liu YX, Enders A, Martin H, Stoikos C, Wallace E, Salamonsen L. IL-11 and IL-11Ralpha immunolocalisation at primate implantation sites supports a role for IL-11 in placentation and fetal development. Reprod Biol Endocrinol 1:34 2003.

Hall MA, Curtis DJ, Metcalf D, Elefanty AG, Sourris K, ROBB L, Gothert JR, Jane SM, Begley CG. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A 100: 992-7 2003.

Tarlinton D, Light A, Metcalf D, Harvey RP, ROBB L. Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses. J Immunol 170:4002-10 2003.

Hart A, Hartley L, Sourris K, Stadler ES, Li R, Stanley EG, Tam PPL, Elefanty AG, ROBB L. Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Development 129: 3597-3608 2002

Reviews
Forrai A, ROBB L. The gene trap resource: a treasure trove for hemopoiesis research. Experimental Hematology 33:845-856 2005

ROBB L, Tam PP. Gastrula organizer and embryonic patterning in the mouse. Seminars in Cell and Developmental Biology 15: 443-554 2004

Tarrant J, ROBB L, van Spriel A-M, Wright MD. Tetraspanins: molecular organisers of the leucocyte surface Trends in Immunology 24: 610-7 2003

Forrai A, ROBB L. The hemangioblast: between blood and vessels. Cell Cycle 2:86-90 2003.

Chapters
ROBB L, Choi, K. Developmental Origin of Murine Hematopoietic Cells. in Stem Cells Handbook. ed S Sell, Humana Press, Totowa, NJ. p133-143 2004