Network Member Profile
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Professor Sandra Rees
Department:
Anatomy and Cell Biology
Organisation:
University of Melbourne
Address:
Parkville, Victoria, 3010
Telephone: 03 8344 5797 Facsimile: 03
9347 5219
Email: s.rees@unimelb.edu.au
Web
Address
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Current Field of Study
- The development of the fetal brain and retina: effects of intrauterine
hypoxia, infection and alcohol exposure.
- The effects of premature birth on brain development and cerebral damage;
retinopathy of prematurity.
Australian Collaborators
- Professor Richard Harding and Dr Megan Probyn (Department of Physiology,
Monash University, Melbourne, VIC)
- Professor John Newnham, Drs I. Nitsos and T. Moss (School of Women and Infant
Health, University of Western Australia, Perth, WA)
- A/Professor Terry O'Brien (Department of Medicine, Royal Melbourne Hospital,
Melbourne, University of Melbourne, VIC)
- Dr Michael Salzberg (Department of Psychiatry, University of Melbourne,
Melbourne, VIC)
- Professor Margaret Morris (Department of Physiology and Pharmacology, University
of NSW, Sydney, NSW)
- Dr Lara Shekerdemian (The Royal Children's Hospital, Melbourne, VIC)
- Professor Catriona McLean (Department of Anatomical Pathology, Alfred Hospital,
Melbourne, VIC).
- Associate Professor Greg Rice (Translational Proteomics, Baker Heart Institute,
Melbourne, VIC).
International Collaborators
- Associate Professors Terrie Inder and Jeff Neil (Departments of Neonatal
Neurology and Neurology, Washington University, St Louis, USA)
- Drs Pierre Gressens and Catherine Verney (INSERM U676, Hôpital Robert
Debré, Paris, France)
- Dr Zoltan Molnar (Department of Physiology, Anatomy and Genetics, University
of Oxford, Oxford, UK)
- Drs Rebecca Folkerth, Robyn Haynes, Jhodie Duncan (Department of Neurology,
Harvard University, Boston, USA)
- Dr Jaqueline Coalson and Don McCurnin (Southwest Foundation for Biomedical
Research, San Antonio, Texas, USA)
Facilities
- Quantitative analysis of developing fetal brain and retina development
following intrauterine exposure to adverse factors
- tereological techniques
- Immunohistochemistry, tissue culture, electron microscopy
- Western Blotting, ELISA
- Small animal surgery
Lab Members
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Prof Sandra Rees
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Head of the Lab
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Dr Mary Tolcos
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Senior Research Officer
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| Dr Michelle Loeliger |
Research Officer
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| Ms Rachael O'Dowd |
Research Assistant |
| Ms Nadia Hale |
Research Assistant |
| Ms Amy Shields |
Research Assistant |
| Mrs Dora Vassilidis |
Senior Technical Officer |
| Ms Anna Mackintosh |
Honours Student 2007 |
| Ms Rachel Marwick |
Visiting MSc Student |
Recent Grant Income
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Description
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CIs
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Type of Grant
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Year
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Income p.a.
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| The effect of stress and hypercortisolaemia on
limbic epileptogenesis and affective disorder. |
A/Prof Terence O'Brien, A/Prof Margeret Morris,
Dr Mike Salzberg, A/Prof Sandra Rees, A/Prof Dennis Velakoulis. |
NHMRC Program Grant |
2006-2008 |
$125,875 |
| New insights into brain injury in young infants
after heart surgery. |
Dr Lara Shekerdemian, A/Prof Terrie Inder, Prof
Daniel Penny, A/Prof Sandra Rees. |
National Heart Foundation Research Grant |
2006-2007 |
$50,000 |
| Protecting the preterm fetal brain from hypoxia
and infection: A healthy start to life. |
A/Prof. S. Rees, Prof. R. Harding, Dr M. Cock,
A/Prof. G. Rice. |
NHMRC Project Grant |
2005-2007 |
$185,000 |
Recent Publications
NITSOS I., REES S., DUNCAN J., KRAMER J., HARDING R., NEWNHAM, MOSSChronic
exposure to intra-amniotic lipopolysaccharide affects the ovine fetal brain.J
Soc Gynecol Invest (2006); 13: 239-47LOELIGER M., DUNCAN J., COCK M., HARDING
R., REES, S. Vulnerability of dopaminergic amacrine cells and optic nerve myelination
to prenatal endotoxin exposure. Invest Ophthal Vis Sci (2006); in press
LOELIGER M., INDER T., CAIN S., RAMESH C., CAMM E., THOMSON M., COALSON J.,
REES S. Cerebral outcomes in a preterm baboon model of early versus delayed
nasal continuous positive airway pressure. Pediatrics (2006); in press
BRISCOE, T., TOLCOS M., DIENI S., LOELIGER M., REES, S. Neuronal growth from
prenatally compromised fetuses: investigating the effects of BDNF in vitro.
Neuroreport (2006); 19: 1385-9
DUNCAN, J., COCK, M., SUZUKI, K., SCHEERLINCK, J-P., HARDING, R., REES, S. Systemic
bacterial endotoxin infusion causes brain injury in the ovine fetus in the absence
of hypoxemia. (J. Soc. Gynecol. Invest.,in press (2006).; 13: 87-96
BRISCOE, T., DUNCAN, J., COCK, C., CHOO, J., RICE, G., HARDING, R., SCHEERLINCK,
J-P., REES, S. Activation of NF-?B transcription factor in the preterm ovine
brain and placenta after acute LPS-exposure. J. Neurosci. Res.,in press (2006);
83: 567-74.
REES, S., HARDING, R., INDER, T. The developmental environment and the origins
of neurological disorders, In: Developmental Origins of Health and Disease.
Eds, P.D. GLUCKMAN and M.A. HANSON. Cambridge University Press (in press 2006).
LOELIGER, M., REES, S. Immunocytochemical development of the guinea pig retina.
Exp Eye Res, (2005) 80: 9-21. DIENI, S., REES, S. BDNF and TrkB protein expression
is altered in the fetal hippocampus but not cerebellum after chronic prenatal
compromise. Exp. Neurol., (2005) 192: 265-273.
INDER, T., NEIL, J., KROENKE, C., DIENI, S., YODER, B., REES, S. Investigation
of cerebral development and injury in the prematurely-born primate by magnetic
resonance imaging and histopathology. Dev. Neurosci, (2005) 27: 100-111.
TAHER, T.R., SALZBERG, M., MORRIS, M.J., REES, S., O'BRIEN, T.J. Chronic low-dose
corticosterone supplementation enhamces acquired epileptogenesis in the rat
amygdala kindling model of TLE. Neuropsychopharmacology, (2005) 30: 1610-1616.
CAMM, E., GIBBS, M.E., HARDING, R., MULDER , T., REES, S.M. Prenatal hypoxia
impairs memory function but does not result in overt structural alterations
in the postnatal chick brain. Brain Res. Dev. Brain Res., (2005) 160: 9-18.
LOELIGER, M., DUNCAN, J., LOUEY, S., COCK, M., HARDING, R., REES, S. Fetal growth
restriction induced by chronic placental insufficiency has long-term effects
on the retina but not the optic nerve. Invest. Opthalmol. Vis. Sci., (2005)
46: 3300-3308.
INDER, T., NEIL, J., YODER, B., REES, S. Pattern of cerebral injury in a primate
model of preterm birth and neonatal intensive care. J. Child Neurol,. (2005),20:2-3.
REHN, A., REES, S. Investigating the neurodevelopmental hypothesis of schizophrenia.
Clin. Exp. Pharmacol. Physiol., (2005) 32: 687-696.REES, S., INDER, T. Fetal
and neonatal origins of altered brain development. Early Human Dev., (2005)
81: 753-761
DUNCAN, J.R., COCK, M.L., LOELIGER, M., LOUEY, S., HARDING, R., REES, S. Effects
of exposure to chronic placental insufficiency on the postnatal brain and retina
in sheep. J. Neuropath. & Exp. Neuro., (2004) 63: 1131-1143.
DUNCAN, J., CAMM, E., LOELIGER, M., COCK, M., HARDING, R., REES, S. Effects
of umbilical cord occlusion in late gestation on the ovine fetal brain and retina.
J Soc Gynecol Investig. (2004) 11:369-76.
LOELIGER, M., BRISCOE, T., LAMBERT, G., CADDY, J., REHN, A., DIENI, S., REES,
S. Chronic placental insufficiency affects retinal development in the guinea
pig. Invest Ophthalmol Vis Sci. 2004 45:2361-7.
BRISCOE, T., REHN, A., DIENI, S., DUNCAN, J., WLODEK, M., OWENS, J., REES, S.
Compromised cardiovascular, renal and adrenal pathophysiology in the adolescent
guinea pig following chronic placental insufficiency. Am J Obstet Gynecol (2004)
191:847-855.
DUNCAN, J.R., COCK, M.L., HARDING, R., REES, S. Neurotrophin expression in the
hippocampus and cerebellum is affected by chronic placental insufficiency in
the late gestational ovine fetus. Dev Brain Res., (2004) 153: 243-250.
REHN, A., VAN DEN BUUSE, M., COPOLOV, D., BRISCOE, T., LAMBERT, G., REES, S.
An animal model of chronic placental insufficiency: Relevance to neurodevelopmental
disorders including schizophrenia. Neuroscience, (2004) 129: 381-391.
DIENI, S., INDER, T., YODER, B., BRISCOE, T., EGAN, G., REES, S. The pattern
of cerebral injury in a primate model of preterm birth and neonatal intensive
care. J. Neuropath. & Exp. Neurol, (2004) 63: 1297-1309. INDER, T., NEIL,
J., YODER, B., REES, S. Non-human primate models of neonatal brain injury. Semin
Perinatol, (2004) 28: 396-404.
REES, S. HARDING, R. Brain development during fetal life: influences of the
intra-uterine environment. Neurosci Lett., (2004) 361: 111-114.
TOLCOS, M., TIKELLIS, C., REES, S., COOPER, M., WOOKEY, P. Ontogeny of calcitonin
receptor mRNA and protein in the developing central nervous system of the rat.
JCN. 456(1):29-38 (2003).
LOELIGER, M., REES, S.M., REYNOLDS, J., PENNING, D., HARDING, R., WATSON, C.S.
& BOCKING, A.D. Intermittent umbilical cord occlusions: relationship between
cerebral extracellular glutamate levels and consequent neuropathology in the
fetal sheep. Neuroscience (2003) 116:705-714.
DIENI, S. and REES, S. Dendritic morphology is altered in hippocampal neurons
following prenatal compromise. J. Neurobiol. (2003) 55:41-52.
TOLCOS, M., HARDING,R., LOELIGER, M. BREEN, S., COCK, M. DUNCAN, J., & REES,
S. The fetal brainstem is relatively resistant to injury following acute or
chronic hypoxemia. Brain Res. Dev. Brain Res. (2003) 143:73-81.
DUNCAN, J.R., COCK, M.L., REES, S., & HARDING, R. The effects of repeated
endotoxin exposure on placental structure in the sheep. Placenta (2003) 24:786-789.
DALITZ, P., HARDING, R., REES, S., & COCK, M. Prolonged reductions in placental
blood flow and cerebral oxygen delivery in preterm fetal sheep exposed to endotoxin:
Possible factors in white matter injury after acute infection. J. Soc. Gynecol.
Invest. (2003) 10:283-290.
LOELIGER, M., LOUEY, S., HARDING, R., COCK, M., & REES, S. Chronic prenatal
compromise leads to long-term affects on the retinal structure. Clin. Exp. Opthalmol.
(2003) 31:250-253.
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