You are here: NGED > Research Portfolio - Members

Network Member Profile

Current Field of Study

• Early life programming of metabolic homeostasis and endocrine function; control of placental and fetal development

Australian Collaborators

• Professor Jeffrey Robinson (University of Adelaide, Adelaide, SA)
• Dr Claire Roberts (University of Adelaide, Adelaide, SA)
• Associate Professor Mary Wlodek (University of Melbourne, Melbourne, VIC)
• Professor Richard Harding (Monash University, Melbourne, VIC)
• Associate Professor Ruth Morley (The Murdoch Children’s Research Institute,
• Melbourne, VIC)
• Professor Eugenie Lumbers (UNSW, Sydney, NSW)
• Professor Marelyn Wintour (Monash University, Melbourne, VIC)
• Dr Karen Moritz (Monash University, Melbourne, VIC)
• Dr Vivienne Perry, Pastoral Veterinary Centre, University of Queensland, Qld

International Collaborators

• Professor Michael Symonds (University of Nottingham, Nottingham, UK)
• Professor Abigail Fowden (Cambridge University, Cambridge, UK)
• Associate Professor Marie Dziadek (University of Auckland, Auckland, NZ)

Facilities

Recent Publications

Books

1. Wintour-Coghlan ME and Owens JA (2005) Co-editor, Book, “Early life origins of adult health and disease” Landes Biosciences, Texas, USA.

Research Publications

1. Morley R, Moore VM, Dwyer T, Owens JA , Umstad MP & Carlin JB (2005) The association between erythropoietin in cord blood of twins and size at birth: does it relate to gestational factors, or factors during labour or delivery Pediatric Research, 57(5): 680 – 684
2. Lipsett J, Tambling M, Madigan K, Przchodzen P, Cool JC, Runciman SIC, McMillen IC, Robinson JS, Owens JA (2005). The effect of placental restriction on lung development in the fetal sheep in late gestation: a morphometric analysis of pulmonary structure. Pediatric Research, 57(5Pt1): 680-684.
3. Horton DM, Kind KL, Walker MR, Robinson JS & Owens A . (2005) Fetal growth restriction and accelerated postnatal growth independently predict insulin resistance in the adult guinea pig American Journal of Physiology (Accepted subject to revision)
4. De Blasio MJ, Gatford KL, Walker MR, Fielke SL, McMillen IC, Robinson JS & Owens JA (2005) Placental restriction of fetal growth reduces size at birth and increases postnatal growth and adiposity in the young lamb. American Journal of Physiology (Accepted subject to revision)
5. De Blasio MJ, Gatford KL, Robinson JS & Owens JA. (2005) Placental restriction alters circulating thyroid hormone in the young lamb postnatally. American Journal of Physiology (Accepted subject to revision)
6. Grant PA, Kind KL, Roberts CT, Sohlstrom A, Owens JA & Owens PC (2005) Pregnancy Increases Hepatic Expression of Insulin-like Growth Factor-I in Well Nourished Guinea Pigs. Growth Hormone and IGF Research, 15: 165-171
7. Quigley SP, Kleeman DO, Kakar MA, Owens JA , Nattras, GS, Maddocks, S & Walker SK (2005) Myogenesis in sheep is altered by variable maternal feed intake during the peri-conception period. Animal Reproductive Science, 87(3-4): 241-251
8. Kind KL, Roberts CT, Sohlstrom A, Katsman A, Clifton PM, Robinson JS & Owens JA . (2005) Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig. American Journal of Physiology, 288(1): R119 - R126
9. Owens JA, Gatford KL, De Blasio MJ, Horton DM, Kind KL, Robinson JS (2005) Perinatal programming of metabolic homeostasis. In: Perinatal Programming: Early Life Determinants of Adult Health & Disease. Hodgson D, Coe C (Editors) Taylor and Francis Medical Books, UK (in press).
10. Belobrajdic DP, McIntosh GH & Owens JA (2004) A high whey- protein diet reduces body weight gain and alters insulin sensitivity relative to red meat in the Wistar rat. Journal of Nutrition, 134: 1454 - 1458
11. Briscoe TA, Rehn AE, Diene S, Duncan JR, Wlodek ME, Owens JA & Rees SM (2004) Cardiovascular and renal pathology in the adolescent guinea pig following chronic placental insufficiency. American Journal of Obstetrics and Gynecology, 191(3): 847 - 855
12. Gatford KL, De Blasio MJ, Thavaneswaran P, Robinson JS, McMillen IC & Owens JA (2004) Postnatal ontogeny of glucose homeostasis and insulin action in the sheep. American Journal of Physiology (Endocrinology and Metabolism), 286: E1050 – E1059
13. Belobrajdic DP, McKintosh GH & Owens JA (2003) Whey proteins protect more than red meat against azoxymethane induced ACF in Wistar rats. Cancer Letters, 198; 43-51
14. Kind KL, Clifton PM, Grant PA, Owens PC, Sohlstrom A, Roberts CT, Robinson JS & Owens JA (2003) Effect of maternal feed restriction during pregnancy on glucose tolerance in the adult guinea pig. American Journal of Physiology, 284: R140-152.
15. Gatford KL, Ekert JE, Blackmore K, DeBlasio MJ, Boyce JM, Owens JA , Campbell RG & Owens PC (2003) Variable maternal nutrition and growth hormone treatment in the second quarter of pregnancy in pigs alter semitendinosus muscle in adolescent progeny. British Journal of Nutrition, 90: 283 – 293.
16. Kind KL, Simonetta G, Clifton PM, Grant PA, Owens PC, Sohlstrom A, Roberts CT, Robinson JS & Owens JA (2002) Effect of maternal feed restriction on blood pressure in the adult guinea pig. Experimental Physiology, 87.4: 469-477.
17. Roberts CT, Kind KL, Earl RA, Grant PA, Robinson JS, Sohlstrom A, Owens PC & Owens JA (2002) A role for insulin-like growth factor-I and its binding proteins –1, -3 in placental development in the guinea pig. Placenta, 23: 763-770.
18. Gatford KL, Clarke IJ, De Blasio MJ, Adams D, McMillen IC, Robinson JS & Owens JA (2002) Perinatal growth and plasma growth hormone profiles in adolescent and adult sheep. Journal of Endocrinology, 173:151-159.
19. CL Coulter, JT Ross, JA Owens , HPJ Bennett and McMillen IC (2002) Role of pituitary POMC-peptides and growth factors in the developmental biology of the adrenal gland. Archives in Physiology and Biochemistry, 110:99-105.
20. Morley R, Owens J , Blair E and Dwyer T (2002). Is birth weight a good marker for gestational exposures that increase risk of adult disease? Pediatric and Perinatal Epidemiology, 16(3): 194-199.
21. Robinson JS, McMillen C, Edwards L, Kind K and Owens JA (2001) Maternal and placental influences that programme the fetus: experimental findings. In: Fetal Origins of Cardiovascular and Lung Disease. Lung Biology in Health and Disease. C. Lefant (Ed). Marcel Dekker Publishing pp273-295.
22. Sohlstrom A, Fernberg P, Owens JA & Owens PC (2001) Maternal nutrition affects the ability of treatment with IGF-I and IGF-II to increase growth of the placenta and fetus in guinea pigs. Growth Hormone & IGF Research, 11(6): 392-398.
23. Edwards L, Symonds ME, Warnes, KE, Owens JA , Butler TG, Jurasevic A & McMillen IC (2001) Responses of the fetal-pituitary adrenal axis to acute and chronic hypoglycaemia during late gestation in the sheep. Endocrinology, 142: 1778-1785.
24. Roberts CT, Sohlstrom A, Kind KL, Grant PA, Earl RA, Robinson JS, Khong TY, Owens PC & Owens JA (2001) Altered placental structure induced by maternal food restriction in guinea pigs: a role for IGF-II and IGFBP-2? Placenta, 22 (Suppl A) S77-S82
25. Marsh AC, K J Gibson, J Wu, P C Owens, J A Owens & E R Lumbers (2001) Insulin-like growth factor I alters renal function and stimulates renin secretion in late gestation fetal sheep. Journal of Physiology, 530: 253-262
26. Marsh AC, K J Gibson, J Wu, P C Owens, J A Owens & E R Lumbers (2001) Chronic effect of insulin-like growth factor I on renin synthesis, secretion, and renal function in fetal sheep. American Journal of Physiology, 281(1): R318-326.
27. McMillen IC, Adams MB, Ross JT, Coulter CL, Simonetta G, Owens JA , Robinson JS and Edwards L (2001) Fetal growth restriction: adaptations and consequences. Reproduction, 122(2): 195-204.
28. Roberts CT, Sohlstrom A, Kind KL, Earl RA, Khong TY, Robinson JS, Owens PC & Owens JA (2000) Maternal food restriction reduces the exchange surface area and increases the barrier thickness of the placenta in the guinea pig. Placenta, 22: 177-185.
29. Phillips ID, Anthony RV, Simonetta G, Owens JA , Robinson JS & McMillen IC (2000) Restriction of fetal growth has a differential impact on fetal prolactin and prolactin receptor mRNA expression. Journal of Neuroendocrinology, 13: 175-181.
30. Ross JT, Phillips ID, Simonetta G, Owens JA , Robinson JS & McMillen IC (2000) Impact of placental restriction on adrenal steroidogenesis, IGF-II and ACTH Receptor mRNA levels in the sheep fetus. Journal of Neuroendocrinology, 12: 70-85.
31. McMillen IC, Warnes, KE, Adams MB, Robinson JS, Owens JA & Coulter CL (2000) Impact of restriction of placental and fetal growth on expression of 11 beta hydroxysteroid dehydrogenase type 1 and 2 m RNA in the liver and kidney of the sheep fetus. Endocrinology, 141: 539-543.
32. Zhang DY, Lumbers ER, Wu JJ, Simonetta G, Owens JA , Robinson JS & McMillen IC (2000) Effects of placental insufficiency on the ovine fetal renin angiotensin system. Experimental Physiology, 85: 79-84.
33. Gatford KL, Wintour EM, De Blasio M, Owens JA & Dodic M (2000) Differential timing for programming of glucose homeostasis, sensitivity to insulin and blood pressure by in utero exposure to exposure to dexamethasone in sheep. Clinical Science, 98: 553-560
34. Gatford KL, Owens JA , Campbell RG, Boyce JM, Grant PA & Owens PC (2000) Treatment of underfed pigs with GH throughout the second quarter of pregnancy increases fetal growth. Journal of Endocrinology, 166: 227-234.
35. Kleeman D, Seamark RS & Owens JA (2000) Effect of periconceptual maternal progesterone supplementation on fetal and placental size in mid gestation in the sheep. Placenta, 22: 14-23.
36. Robinson JS, Moore VM, Owens JA and McMillen IC. (2000) Origins of fetal growth restriction. European Journal of Obstetrics, Gynecology and Reproductive Biology, 92(1): 13-19.