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Network Member Profile

Current Field of Study

• fertilisation - regulation of sperm fertility
• early embryo - physiology, epigenetics and medicine
• embryonic stem cells - basic cell physiology
• maternal recognition of pregnancy - regulation of implantation and the maintenance of pregnancy

Australian Collaborators

• Dr Margot Day, University of Sydney
• Prof David Cook, University of Sydney
• Dr Emma Whitelaw, University of Sydney
• Dr Nick King, University of Sydney
• Prof Gareth Evans, University of Sydney
• Dr Tomas Stojanov, Sydney IVF P/L

International Collaborators

• Prof Gigi Lozano, MD Anderson, TX
• Prof Fuller Bazer, TAMU, TX
• Prof Takao Shimizu, U. Tokyo
• Dr Orly Reiner, Weizmann I, Israel
• Dr Anthony Wynshaw-Boris, University of California, San Diego, CA

Recent Publications

Li A, Chandrakanthan V, Chami O, O'Neill C (2006) Culture of Zygotes Increases p53 Expression in B6 Mouse Embryos which Reduces Embryo Viability. Biology of Reproduction DOI:10.1095/biolreprod.106.056838.

Chandrakanthan,V. Li, A. Chami, O. O'Neill, C. (2006) Effects of in vitro fertilization and embryo culture on TRP53 and Bax expression in B6 mouse embryos. Reproductive Biology and Endocrinology. 4:61.

O'Neill, C. (2005). "The role of paf in embryo physiology." Human Reproduction Update 11(3): 215-28.

Lu DP, Chandrakanthan V, Cahana A, Ishii S, O'Neill C. (2004) Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development. Journal of Cell Science. 117(Pt 8):1567-76.

Chami O, Evans G, O'Neill C. (2004) Components of a platelet-activating factor-signaling loop are assembled in the ovine endometrium late in the estrous cycle. American Journal of Physiology: Endocrinology and Metabolism. 287(2):E233-40.

Lu, D.P. Li, Y., Bathgate, R. Day, M.L. and O'Neill, C. (2003) Ligand Activated Signal Transduction in the 2-cell Embryo. Biology of Reproduction 69, 106–116

A. Cahana, A. Jin X.L. Reiner, O. Wynshaw-Boris, A. and O'Neill, C. (2003) A Study Of The Nature Of Embryonic Lethality In Lis1 -/- Mice. Molecular Reproduction and Development 66, 134-142.

Lu, D.P., Chandrakanthan, V,. Cahana, A., Ishii, S. and O'Neill, C. (2003) Trophic signals acting via phosphatidylinositol-3 kinase are Required for Normal Preimplantation Mouse Embryo Development. Journal of Cell Science. Accepted for Publication. 18/11/03.

O'Neill, C. (2002) Platelets and the preimplantation stage of embryo development. In Platelets in thrombotic and non-thrombotic disorders pathophysiology, pharmacology and therapeutics. Eds, Gresele, P. Page, C.P., and Vermylen, J. Cambridge University Press. pp 885-893.

Lu, D.P. Tian, L. O'Neill, C. and King, N.J.C. (2002) Regulation of Expression of CAMs in Murine Oocytes, Peri-implantation and Post-implantation Embryos. Cell Research 12, 373-383

Stojanov, T. and O'Neill, C. (2001) In vitro Fertilization causes epigenetic modifications to the pattern of gene expression from the zygotic genome in mice. Biology of Reproduction 64(2):696-705.

Chami, O. and O'Neill, C. (2001) Identification and regulation of the platelet-activating factor acetylhydrolase activity in the mouse uterus in early pregnancy. Reproduction Fertility and Development. 13: 367-76.

Wu, C.J. Stojanov, T. Chami,O. Ishii, S. Shimizu, T. Li, A. and O'Neill, C. (2001) Evidence for the Autocrine Induction of Capacitation of Mammalian Spermatozoa. Journal of Biological Chemistry 276: 26962-26968.

Emerson, M. Travis, A.R. Bathgate, R. Stojanov, T. Cook, D.I. Harding, E. Lu, D.P and O'Neill, C. (2000) Characterization and Functional Significance of Calcium Transients in the 2-cell Mouse Embryo Induced by an Autocrine Growth Factor. Journal of Biological Chemistry 275: 21905-21913.