Network Member Profile
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Dr Don Newgreen
Department:
Department of Embryology
Organisation:
Murdoch Children’s Research Institute
Address:
Flemington Road, Parkville, VIC 3052
Telephone: 03 8341 6276 Facsimile:
03 9348 1391
Email: don.newgreen@mcri.edu.au
Web Address
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Current Field of Study
- Developmental biology : neural crest; cell migration; epithelium-mesenchyme transition; carcinoma metastasis
Australian Collaborators
- A/Prof Kerry Anne Landman, Dept Mathematic and Statistics, University of
Melbourne, Vic.
- Dr Heather Young, Dept. Anatomy and Cell Biology, Melbourne, Vic.
- A/Prof Erik Thompson, Bernard O’Brien Institute, Melbourne, Vic.
- Dr Leigh Ackland, Centre for Cellular & Molecular Biology, Deakin University,
Melbourne, Vic.
- Dr Stephen Stacker, Ludwig Institute, Melbourne, Vic.
- Prof Mike Hubbard, Dept Paediatrics and School of Dental Science, Univ Melbourne,
Melbourne, Vic.
- Dr Simon Koblar, Centre for the Molecular Genetics of Development, University
of Adelaide, SA.
International Collaborators
- Prof Margaret L Kirby, Duke University Medical Centre, Durham, NC, USA
- Dr Yoshio Wakamatsu, Developmental Neurobiology, Tohoku University, Sendai,
Japan
- Dr M. A. Nieto, Instituto Cajal, Madrid, Spain
- Prof. M. Frame, Beatson Inst., Glasgow, UK.
Facilities
- In ovo electroporation
- Neural Tube explant system
- Microarray facility
- Proteomics (2D-PAGE and MALDI-MS)
- Time-Lapse imaging
- Confocal and conventional Time-Lapse imaging
Lab Members
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Dr Don Newgreen
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Head of the Lab
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Dr Honor Hugo
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Postdoctoral fellow
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Dr Matthew Simpson
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Postdoctoral fellow (based at Dept Maths, Melb Univ.)
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| Mr Dong Zhang |
Research Assistant |
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Dr Tam Dieu
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PhD Student
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| Dr Tamara Bonney |
PhD Student |
Recent Grant Income
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Description
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CIs
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Type of Grant
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Year
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Income p.a.
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| Molecular control of mandibular development |
PG Farlie, DF Newgreen |
NHMRC Project Grant |
2004-2006 |
$115,000 |
| Molecular Markers for Epithelio-Mesenchymal Transition in
Human Breast Cancer |
Dr E Thompson,Dr M Waltham, Dr M Henderson, Dr D Newgreen,
Dr L. Ackland |
Dept of Defence IDEA Grant |
2003-2005 |
$US100,000 |
| Biological and Mathematical Studies of Development of the
Enteric Nervous System |
DF Newgreen, KA Landman, PG Farlie |
NH&MRC Project |
2003-2005 |
$120,000 |
Recent Publications
Landman KA, Simpson MJ, Slater JL and Newgreen DF (2005) Diffusive and chemotactic
cellular migration: smooth and discontinuous travelling wave solutions. Soc.Ind.
Appl. Math. J. Appl. Math. 65:1420 -1442
Gilles, C, Newgreen DF and Sato, H and Thompson EW (2005) Matrix metalloproteases
and epithelial-to-mesenchymal transition: Implications for carcinoma metastasis.
In: Rise and Fall of Epithelial Phenotype, edited by P Savagner. ISBN: 0-306-48239-8
Landes Bioscience, Texas, USA.
Newgreen DF and McKeown, SJ (2005) Neural crest cells migration. In: Rise and
Fall of Epithelial Phenotype: Concepts of Epithelial-Mesenchymal Transition,
edited by P Savagner. ISBN: 0-306-48239-8 Landes Bioscience, Texas, USA.
McKeown SJ, Lee V, Bronner-Fraser M, Newgreen DF, Farlie PG (2005) Sox10 induces
neural crest from all dorsoventral levels of the neural tube and maintains an
undifferentiated state. Dev Dynamics 233:430-444.
Dieu T, Johnstone BR and Newgreen DF (2005) Genes and nerves. J Recon Microsurg
21: 179-186.
McKeown SJ, Newgreen DF, Farlie PG (2005) Dlx2 regulates cell adhesion during
craniofacial morphogenesis. Dev Biol. 281:22-37.
Simpson MJ, Landman KA and Newgreen DF (2005) Chemotactic and diffusive migration
on a non-uniformly growing domain: Numerical algorithm development and applications.
J Comput Appl Math (accepted 3 May 2005)
Thompson EW and Newgreen DF (2005) Carcinoma invasion and metastasis: a role
for Epithelial-Mesenchymal Transition? Cancer Res. 65:5991-5995.
Newgreen DF and Thompson EW (2005). Preface to Recent Progress in Epithelial-Mesenchymal
Transitions: Development, Cancer, Pathology. Cells Tissues Organs 179:5-10.
Anderson RB, Newgreen DF and H.M. Young HM (2005) Neural Crest and the Development
of the Enteric Nervous System. In: Neural Crest Induction and Differentiation,
edited by Jean-Pierre Saint-Jeannet. ©2005 Eurekah.com. (in press)
Young HM, Newgreen DF, Burns AJ (2005) The development of the enteric nervous
system in relation to Hirschsprung's disease. In: Embryos, Genes and Birth Defects
(2nd ed.). P. Ferretti, (ed.) John Wiley and Sons (in press).
Farlie PG, McKeown SJ, DF. Newgreen DF (2004) The neural crest: Basic biology
and clinical relationships in the craniofacial and enteric nervous systems.
Birth Defects Res Part C Embryo Today 72:173-189.
Lewis SL, Farlie PG, and Newgreen DF (2004) Isolation and embryonic expression
analysis of avian ADAM 12 and ADAM 19. Mec Dev [Gene Expr Patterns] 5: 75-79.]
Russo VC, Andaloro E, Fornaro SA, Najdovska S., Newgreen DF., Bach LA, Werther
GA (2004) Fibroblast growth factor-2 over-rides insulin-like growth factor-I
induced proliferation and cell survival in human neuroblastoma cells. J Cell
Physiol. 199:371-380.
Yan, H., Bergner, A.J., Enomoto, H., Milbrandt, J., Newgreen, D.F. and Young,
H.M. (2004) Neural cells in the esophagus respond to glial cell line-derived
neurotrophic factor and neurturin, and are Ret-dependent. Dev. Biol. 272:118-133.
Young HM, Bergner AJ, Anderson RB, Enomoto H, Millbrandt J, Newgreen DF and
Whitington PM (2004), Dynamics of neural crest migration in the embryonic mouse
gut. Dev Biol 270: 455-473
McKeown SJ, Newgreen DF and Farlie PG. (2003) Temporal restriction of migratory
and lineage potential in rhombomere 1 and 2 neural crest. Dev Biol. 255:62-76.
Bates D, Taylor GI, Minichiello J, Farlie P, Cichowitz A, Watson NF, Klagsbrun
M, Mamluk R and Newgreen DF. (2003) Neurovascular congruence results from a
shared patterning mechanism that utilizes Semaphorin3A. Dev Biol 255:77-98.
Landman KA, Pettet GJ, and Newgreen DF. (2003) Mathematical models of cell
colonisation of uniformly growing domains. Bull. Math. Biol. 65: 235-262.
Landman KA, Pettet GJ, and Newgreen DF. (2003) Chemotactic cellular migration:
smooth travelling wave solutions. SIAM J. Appl. Math. 63:1666-1681.
Ackland ML, Newgreen D*, Fridman M, Waltham M, Arvanitis A, Minichiello J,
Price JT and Thompson EW. (2003) Persistence of N-cadherin but reduction of
E-cadherin after EGF-induced epithelio-mesenchymal transition in PMC42-LA human
breast carcinoma cells. Lab. Invest. 83:435-448.(*equal first author)
Yan, H, Newgreen, DF and Young, HM (2003) Developmental changes in neurite
outgrowth responses of dorsal root and sympathetic ganglia to GDNF, neurturin
and artemin. Dev. Dyn. ;227:395-401
Russo VC, Fornaro SA, Andaloro E, Najdovska S., Newgreen DF., Bach LA, Werther
GA (2003) Fibroblast Growth Factor-2 inhibits Insulin-like Growth Factor-I action
and promotes differentiation of neuroblastoma cells by regulation of IGFBP levels
and modulation of apoptotic signaling pathways. (Accepted 2/7/03 J. Cellular
Physiol.)
PUBLICATIONS IN PRESS
Gilles, C, Newgreen DF and Sato, H and Thompson EW (2004) Matrix metalloproteases
and epithelial-to-mesenchymal transition: Implications for carcinoma metastasis.
In: Rise and Fall of Epithelial Phenotype, edited by Pierre Savagner. ©2004
Eurekah.com and Kluwer Academic / Plenum Publishers.
Newgreen DF and McKeown, SJ (2004) The neural crest: a model developmental
EMT. In: Rise and Fall of Epithelial Phenotype, edited by Pierre Savagner. ©2004
Eurekah.com and Kluwer Academic / Plenum Publishers.
Young HM, Newgreen DF, Burns AJ (2004) The development of the enteric nervous
system in relation to Hirschsprung’s disease. In: Embryos, Genes and Birth
Defects (2nd ed.). P. Ferretti, (ed.) John Wiley and Sons (in press).
Landman KA, Simpson MJ, Slater JL and Newgreen DF (2004) Diffusive and chemotactic
cellular migration: smooth and discontinuous travelling wave solutions. SIAM
J (in press)
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