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Network Member Profile

Current Field of Study

• The cell biology of bone architecture

Australian Collaborators

• A/Prof David Findlay, Orthopaedic Bone Cell Biology Laboratory, Hanson Institute, Adelaide, South Australia
• Dr Andrew Zannettino, Myeloma and Mesenchymal Research Group, Hanson Institute, Adelaide, South Australia
• Dr Stan Gronthos, Mesenchymal Stem Cell Group, Hanson Institute, Adelaide, South Australia
• Prof Jeffrey Zajac, Department of Medicine, Austin & Repatriation Medical Centre, Melbourne, Victoria

International Collaborators

• Prof Anthony Portale, Pediatric Nephrology, University of California, San Francisco Medical Centre, San Francisco, California, USA
• Prof JoEllen Welsh, Department of Biological Sciences, University of Notre Dame, Indiana 46556, USA

Facilities

• Facilities associated with the Adelaide Integrated Laboratories Central Node containing the Adelaide Proteomics Centre, Adelaide Microscopy and the Adelaide Microarray Facility
• The Detmold Family Imaging Centre
• GenSA mouse gene KO and transgenesis facility

Recent Publications

Gao XH, Dwivedi PP, Omdahl JL, Morris HA, May BK. (2005) Calcitonin stimulates expression of the rat 25-hydroxyvitamin D-24-hydroxylase promoter in HEK-293 cells expressing calcitonin receptor: identification of signalling pathways. J Molec Endocrinol 2004, 32: 87-89.

Hendrix I, Anderson PH, Omdahl JL, May BK, Morris HA. (2005) Response of the 5’-flanking region of the human 25-hydroxyvitamin D 1a -hydroxylase gene to physiological stimuli using a transgenic mouse model. J Mol Endocrinol 2005; 34: 237-245.

Anderson PH, O'Loughlin PD, May BK, Morris HA. (2005) Modulation of CYP27B1 and CYP24 mRNA expression in bone is independent of circulating 1,25(OH)(2)D(3) levels. Bone 2005; 36: 654-662.

Davey RA, Morris HA. (2005) Effects of estradiol and dihydrotestosterone on osteoblast gene expression in osteopenic ovariectomized rats. J Bone Min Metab 2005; 23: 212-218.

Dwivedi PP, Anderson PH, Omdahl JL, Grimes HL, Morris HA, May BK. (2005) Identification of Growth factor independent-1 (GFI1) as a repressor of 25-Hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells. Endocrine-Related Cancer 2005; 12: 1-15.

Cochran M, Coates PTH, Morris HA. (2005) The effect of calcitriol on fasting urine calcium loss and renal tubular reabsorption of calcium in patients with mild renal failure – actions of a permissive hormone. Clin Nephrol 2005; 64: 98-102.

Simpson JA, MacInnis RJ, English DR, Gertig DM, Morris HA, Giles GG. (2005) A comparison of estradiol levels between women with a hysterectomy and ovarian conservation and women with an intact uterus. Climacteric 2005; 8: 300-303.

Davey RA, Morris HA. (2005) The effects of salmon calcitonin-induced hypocalcemia on bone metabolism in ovariectomized rats. J Bone Min Metab 2005; 23: 359-365.

Morris HA. (2005) Vitamin D: A hormone for all seasons – how much is enough? Understanding the New Pressures. Clin Biochem Rev 2005; 26: 21-32.

Gentilcore D, Bryant B, Wishart JM, Morris HA, Horowitz M, Jones KL. (2005) Acarbose attenuates the hypotensive response to sucrose and slows gastric emptying in the elderly. Am J Med 2005; 118:1289.e5-1289.e11.

Atkins GJ, Findlay DM, Anderson PH, Morris HA. (2005) Target Genes: Bone Proteins. In: Vitamin D, 2nd Edition, Eds Feldman D, Pike W, Glorieux FH, Elsevier Academic Press, 2005;711-720.

Need AG, O’Loughlin PD, Morris HA, Horowitz M, Nordin BEC. The effects of age and other variables on serum parathyroid hormone in postmenopausal women. J Clin Endocrinol Metab. 2004 Apr;89(4):1646-9.

Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, Gebre-Mehin S, Galson DL, Zajac JD, Karsenty G. (2005) Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol. 2004 Feb 16;164(4):509-14

Anderson PH, O'Loughlin PD, May BK, Morris HA. (2004) Determinants of circulating 1,25-dihydroxyvitamin D3 levels: the role of renal synthesis and catabolism of vitamin D. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):111-3.

Hendrix I, Anderson P, May B, Morris H. Regulation of gene expression by the CYP27B1 promoter; study of a transgenic mouse model. J Steroid Biochem Molec Biol. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):139-42.

Gao XH, Dwivedi PP, Omdahl JL, Morris HA, May BK. Calcitonin stimulates expression of the rat 25-hydroxyvitamin D-24-hydroxylase promoter in HEK-293 cells expressing calcitonin receptor: identification of signalling pathways. J Molec Endocrinol [accepted for publication 1 October 2003].

Scopacasa F, Wishart JM, Horowitz M, Morris HA, Need AG. Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol. Eur J Clin Nutr. 2004 Feb;58(2):264-9.

Nordin BEC, O’Loughlin PD, Need AG, Horowitz M, Morris HA. Radiocalcium absorption is reduced in postmenopausal women with vertebral and most types of peripheral fractures. Osteoporosis Int 2004 Jan;15(1):27-31. Epub 2003 Nov 04.

O’Loughlin PD, Morris HA. Oophorectomy acutely increases calcium excretion in adult rats. J Nutr 2003; 133: 2277-2280.

Anderson PH, O'Loughlin PD, May BK, Morris HA. Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and VDR in kidney using real-time reverse transcriptase-polymerase chain reaction. J Molec Endocrinol 2003; 31: 123-132.

Anderson PH, May BK, Morris HA. Vitamin D metabolism: new concepts and clinical implications. Clin Biochem Revs 2003; 24: 13-26.

Severi G, Giles GG, Southey MC, Tesoriero A, Tilley W, Neufing P, Morris H, English DR, McCredie MR, Boyle P, Hopper JL. ELAC2/HPC2 polymorphisms, prostate-specific antigen levels and prostate cancer. J Natl Cancer Inst 2003; 95: 818-824.

Vozzo R, Baker B, Wittert GA, Wishart JM, Morris H, Horowitz M, Chapman I. Glycemic, hormone, and appetite responses to monosaccharide ingestion in-patients with type 2 diabetes. Metabolism 2002; 51: 949-957.

Jesudason D, Need AG, Horowitz M, O'Loughlin PD, Morris HA, Nordin BEC. Relationship between serum 25 hydroxyvitamin D and bone resorption markers in vitamin D insufficiency. Bone 2002; 31: 626-630

Dwivedi PP, Hii CST, Ferrante A, Tan J, Der CJ, Omdahl JL, Morris HA, May BK. Role of MAP Kinases in the 1,25-dihydroxyvitamin D 3-induced transactivation of the rat cytochrome P450c24 (CYP24) promoter: specific functions for the ERK1/ERK2 and ERK5. J Biol Chem 2002; 277: 29643-29653.

Scopacasa F, Wishart JM, Need AG, Horowitz M, Morris HA, Nordin BEC. Bone density and bone-related biochemical variables in normal men: a longitudinal study. J Gerontol A Biol Sci Med Sci 2002; 57: M385-M391.

Scopacasa F, Need AG, Horowitz M, Wishart JM, Morris HA Nordin BEC. Effects of dose and timing of calcium supplementation on bone resorption in early menopausal women. Horm Metab Res 2002; 34: 44-47.

Need AG, Kemp A, Giles N, Morris HA, Horowitz M, Nordin BEC. Relationships between intestinal calcium absorption, serum vitamin D metabolites and smoking in postmenopausal women. Osteoporos Int 2002; 13: 83-88.

Omdahl JL, Morris HA, May BK. Hydroxylase enzymes of the vitamin D pathway: Expression, function and regulation. Ann Rev Nutr 2002; 22: 139-166.

Gao X, Dwivedi PP, Choe S, Alba F, Morris HA, Omdahl JL, May BK. Basal and parathyroid hormone induced expression of the human 25-hydroxyvitamin D 1alpha-hydroxylase gene promoter in kidney AOK-B50 cells: role of Sp, Ets and CCAAT box protein binding sites. Int J Biochem Cell Biol 2002;34: 921-930

MacIntosh CG, Morley JE, Wishart J, Morris H, Jansen JB, Horowitz M, Chapman IM. Effect of exogenous cholecystokinin (CCK-8) on food intake and circulating leptin, insulin and CCK concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging. J Clin Endocrinol Metab 2001; 86: 5830-5837.

MacIntosh CG, Horowitz M, Verhagen MA, Smout AJ, Wishart J, Morris H, Goble E, Morley JE, Chapman IC. Effect of small intestinal nutrient infusion on appetite, gastrointestinal hormone release, and gastric myoelectrical activity in young and older men. Am J Gastroenterol 2001; 96: 997-1007.

Beckoff K, MacIntosh CG, Chapman IM, Wishart JM, Morris HA, Horowitz M, Jones KL. Effects of glucose supplementation on gastric emptying, blood glucose homeostasis, and appetite in the elderly. Am J Physiol Regulatory Integrative Comp Physiol 2001; 280: R570-R576.

Takasaki M, Inaba H, Ohta A, Motohashi Y, Sakai K, Morris H, Sakuma K. Dietary short-chain fructooligosaccharides increase calbindin-D9k only in the large intestine in rats independent of dietary calcium deficiency or serum 1,25 dihydroxy vitamin D levels. Int J Vitamin Nutr Res 2000; 70: 206-213.

Moore AJ, Morris HA, Larik R, O’Loughlin PD. Effects of dietary calcium restriction on radiocalcium absorption and trabecular bone structure in the rat. In: Norman AW, Bouillon R, Thomasset M (eds) Vitamin D Endocrine System Structural, Biological, Genetic and Clinical Aspects. University of California, Riverside Cal. 2000; 653-656.

Scopacasa F, Horowitz M, Wishart JM, Morris HA, Chatterton BE, Need AG. The relationship between bone density, free androgen index, and estradiol in men 60 to 70 years old. Bone 2000; 27: 145-149.

Michelangeli V, Morris HA, Topliss D. (Eds.) Current issues in thyroid disease: laboratory and clinical developments. Australasian Association of Clinical Biochemists, Perth WA 2000.

Wishart JM, Scopacasa F, Horowitz M, Morris HA, Need AG, Clifton PM, Nordin BEC. Effect of perimenopause on calcium absorption: a longitudinal study. Climacteric 2000; 3: 102-108.

Scopacasa F, Need AG, Horowitz M, Wishart JM, Morris HA, Nordin BEC. Inhibition of bone resorption by divided dose calcium supplementation in early postmenopausal women. Calcif Tissue Int 2000; 67: 440-442.

Davey RAM, Hahn CN, May BK, Morris HA. Osteoblast gene expression in rat long bones: effects of ovariectomy and dihydrotestosterone on mRNA levels. Calcif Tissue Int 2000; 67: 75-79.

Need AG, Morris HA, Horowitz M, Nordin BEC. Vitamin D status: effects on parathyroid hormone and 1,25 dihydroxyvitamin D in postmenopausal women. Am J Clin Nutr 2000; 71: 1577-1581.