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Network Member Profile

Current Field of Study

• Developmental physiology - the early origins of adult disease

Australian Collaborators

• Prof Michael Waters, School of Biomedical Sciences and the Institute for Molecular Bioscience, The University of Queensland, Brisbane Queensland
• Dr Jim McFarlane, Department of Physiology, University of New England, Armidale, New South Wales
• Dr Ross Tellam, CSIRO Livestock Industries, Brisbane, Queensland
• Dr Tony Vuocolo, CSIRO Livestock Industries, Brisbane, Queensland
• Dr Cathie Coulter, Research Centre for the Early Origins of Adult Health, School of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia
• Dr Jeffrey Schwartz , Research Centre for the Early Origins of Adult Health, School of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia
• Dr Janna Morrison, Research Centre for the Early Origins of Adult Health, School of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia
• Dr Clare Roberts, Obstetrics and Gynaecology, The University of Adelaide, Adelaide, South Australia
• Dr Simon Walker, South Australian Research and Development Institute, Adelaide, South Australia

International Collaborators

• Dr Clare Adam, Rowett Research Institute, Aberdeen, UK
• Professor Russ Anthony, University of Colorado, USA
• Dr Sandy Davidge, Perinatal Research Centre, University of Edmonton, Alberta, Canada
• Professor Duane Keisler, Department of Animal Science, University of Missouri, USA
• Professor David Olson, Perinatal Research Centre, University of Edmonton, Alberta, Canada
• Professor Charles Rosenfeld, Department of Paediatrics, South Western University, Dallas, Texas, USA
• Professor Dan Rurak, Research for Childrens and Womens Health, University of British Columbia,
• Vancouver, Canada
• Professor Paul Sibbons, Bristol University, UK
• Associate Professor Michael Symonds, School of Child Health, University of Nottingham UK
• Professor Kent Thornburg, Heart Research Centre, Oregon Health Sciences University, USA

Facilities

• Specialised Large Animal Surgery Facility
• Endocrine Assay Laboratory
• Molecular Biology Facility

Recent Publications

Owens JA, Thavaneswaran P, De Blasio MJ, McMillen IC, Robinson JS, Gatford KL (2007) Sex-specific effects of placental restriction on components of the metabolic syndrome in young adult sheep. American Journal of Physiology 292:E1879-E1889.

Muhlhausler BS, Duffield JA, McMillen IC (2007) Increased maternal nutrition stimulates Peroxisome Proliferator Activated Receptor-{gamma} (PPAR{gamma}), adiponectin and leptin mRNA expression in adipose tissue before birth. Endocrinology 148:878-885.

Muhlhausler BS (2007) Programming of the Appetite-Regulating Neural Network: A Link Between Maternal Overnutrition and the Programming of Obesity? Journal of Neuroendocrinology 19:67-72.

Morrison JL, Botting KJ, Dyer JL, Williams SJ, Thornburg KL, McMillen IC (2007) Restriction of placental function alters heart development in the sheep fetus. American Journal of Physiology Electronic publication ahead of print.

McMillen IC, Rattanatray L, Duffield JA, Morrison JL, MacLaughlin SM, Gentili S, Muhlhausler BS (2007) The Early Origins of Later Obesity: Pathways and Mechanisms. Advances in Experimental Medicine and Biology Submitted for publication.

McMillen IC, MacLaughlin SM, Muhlhausler BS, Gentili S, Duffield JA, Morrison JL (2007) Developmental origins of adult health and disease: The role of periconceptional and fetual nutrition. Basic & Clinical Pharmacology & Toxicology Submitted for publication.

MacLaughlin SM, Walker SK, Kleemann DO, Sibbons JP, Tosh DN, Gentili S, Coulter CL, McMillen IC (2007) Impact of periconceptional undernutrition on the adrenal growth and adrenal IGF and steroidogenic enzyme expression in the sheep fetus during early pregnancy. Endocrinology 148:1911-1920.

Hyatt M, Gopalakrishnan GS, Bispham J, Gentili S, McMillen IC, Rhind SM, Rae MT, Kyle CE, Brooks AN, Jones C, Budge H, Walker D, Stephenson T, Symonds ME (2007) Maternal nutrient restriction in early pregnancy programmes hepatic mRNA expression of growth hormone prolactin and insulin-like growth factor-II receptors hepatocyte growth factor Bax suppressor of cytokine signalling-3 and liver size in the adult male. Journal of Endocrinology 192:87-97.

Fletcher CJ, Roberts CT, Hartwich KM, Walker SK, McMillen IC (2007) Somatic cell nuclear transfer in the sheep induces placental defects that likely precede fetal demise. Reproduction 133:243-255.

De Blasio MJ, Gatford KL, McMillen IC, Robinson JS, Owens JA (2007) Placental restriction of fetal growth increases insulin action, growth and adiposity in the young lamb. Endocrinology 148:1350-1358.

Muhlhausler BS, Adam CL, Findlay JR, McMillen IC (2006) Increased maternal nutrition alters development of appetite regulatory network in the brain The FASEB Journal 20:E556-E565.

McMillen IC, Edwards LJ, Duffield JA, Muhlhausler BS (2006) Regulation of leptin synthesis and secretion before birth: implication for the early programming of adult obesity. Reproduction 131:415-427.

MacLaughlin SM, Muhlhausler BS, Gentili S, McMillen IC (2006) When in gestation do nutritional alterations exert their effects? A focus on the early origins of adult disease. Current Opinion in Endocrinology and Diabetes 13:516-522.

MacLaughlin SM, McMillen IC (2006) Impact of periconceptional undernutrition on the development of the Hypothalamo-Pituitary-Adrenal axis: Does the timing of parturition start at conception? Current Medicinal Chemistry In Press.

Lipsett J, Tamblyn M, Madigan K, Roberts P, Cool JC, Runciman SIC, McMillen IC, Robinson J, Owens JA (2006) Restricted fetal growth and lung development: A morphometric analysis of pulmonary structure. Pediatric Pulmonology 41:1138-1145.

Gentili S, Waters MJ, McMillen IC (2006) Differential regulation of Suppressor of Cytokine Signaling-3 (SOCS-3) in the liver and adipose tissue of the sheep fetus in late gestation. American Journal of Physiology 290:R1044-R1051.

Gentili S, Schwartz J, Waters MJ, McMillen IC (2006) Prolactin and the expression of suppressor of cytokine signaling-3 (SOCS-3) in the sheep adrenal before birth. American Journal of Physiology 291:R1399-R1405.

Farrand K, McMillen IC, Tanaka S, Schwartz J (2006) Subpopulations of corticotrophs in the sheep pituitary during late Endocrinology 147:4762-4771.

Danielson, L., I. C. McMillen, et al. (2005). "Restriction of placental growth results in greater hypotensive response to {alpha}-adrenergic blockade in fetal sheep during late gestation." Journal of Physiology 563(2): 611-620.

Edwards, L. J., J. R. McFarlane, et al. (2005). "Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies." American Journal of Physiology 288(1): R39-45.

MacLaughlin, S. M., S. K. Walker, et al. (2005). "Periconceptional nutrition and the relationship between maternal body weight changes in the periconceptional period and feto-placental growth in the sheep." Journal of Physiology 565(1): 111-124.

McMillen, I. C., C. L. Adam, et al. (2005). "Early origins of obesity: programming the appetite regulatory system." Journal of Physiology 565(1): 9-17.

McMillen, I. C. and J. S. Robinson (2005). "Developmental origins of the metabolic syndrome: prediction, plasticity, and programming." Physiological Reviews 85: 571-633.

Morrison, J. L., D. W. Rurak, et al. (2005). "Maternal Fluoxetine Infusion Does Not Alter Fetal Endocrine and Biophysical Circadian Rhythms in Pregnant Sheep." Journal of the Society for Gynecologic Investigation 12(5): 356.

Muhlhausler, B. S., C. L. Adam, et al. (2005). "Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation." Journal of Physiology 565(1): 185-195.

Williams, S. J., M. E. Campbell, et al. (2005). "Differential effects of maternal hypoxia or nutrient restriction on carotid and femoral vascular function in neonatal rats." American Journal of Physiology 288(2): R360-367.

Williams, S. J., D. G. Hemmings, et al. (2005). "Effects of maternal hypoxia or nutrient restriction during pregnancy on endothelial function in adult male rat offspring." Journal of Physiology 565(1): 125-135.

Budge, H., L. J. Edwards, et al. (2004). "Nutritional Manipulation of Fetal Adipose Tissue Deposition and Uncoupling Protein 1 Messenger RNA Abundance in the Sheep: Differential Effects of Timing and Duration." Biology of Reproduction 71(1): 359-365.

Gatford, K. L., M. J. De Blasio, et al. (2004). "Postnatal ontogeny of glucose homeostasis and insulin action in sheep." American Journal of Physiology 286(6): E1050-1059.

Keating, D. J., G. Y. Rychkov, et al. (2004). "Opioid receptor stimulation suppresses the adrenal medulla hypoxic response in sheep by actions on Ca2+ and K+ channels." Journal of Physiology 555(2): 489-502.

McMillen, I. C., B. S. Muhlhausler, et al. (2004). "Prenatal programing of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth." Proceedings of the Nutritional Society 63: 405-412.

McMillen, I. C., J. Schwartz, et al. (2004). "Early embryonic environment, the fetal pituitary-adrenal axis and the timing of parturition." Endocrine Research 30(4): 845-850.

McMillen, I. C. C., C. L. (2004). The Feto-Placental Unit. San Diego CA, Elsevier Science.

Morrison, J. L., K. W. Riggs, et al. (2004). "Chronic Maternal Fluoxetine Infusion in Pregnant Sheep: Effects on the Maternal and Fetal Hypothalamic-Pituitary-Adrenal Axes." Pediatric Research 56(1): 40-46.

Muhlhausler, B. S., I. C. McMillen, et al. (2004). "Appetite Regulatory Neuropeptides are Expressed in the Sheep Hypothalamus Before Birth." Journal of Neuroendocrinology 16(6): 502-507.

Warnes, K., I. C. McMillen, et al. (2004). "Metyrapone infusion stimulates adrenal growth without activating the cell cycle or the IGF system in the late gestation fetal sheep." Endocrine Research 30(4): 353-539.

Warnes, K. E., I. C. McMillen, et al. (2004). "Differential Actions of Metyrapone on the Fetal Pituitary-Adrenal Axis in the Sheep Fetus in Late Gestation." Biology of Reproduction 71(2): 620-628.

Williams, S. J., D. M. Olson, et al. (2004). "Cortisol Infusion Decreases Renin, But Not PGHS-2, EP2, or EP4 mRNA Expression in the Kidney of the Fetal Sheep at Days 109-116." Pediatric Research 55(4): 637-644.

Yuen, B. S. J., P. C. Owens, et al. (2004). "Effects of Leptin on Fetal Plasma Adrenocorticotropic Hormone and Cortisol Concentrations and the Timing of Parturition in the Sheep." Biology of Reproduction 70(6): 1650-1657.

Coulter, C. L., M. D. Salkeld, et al. (2003). "Adrenal TGF[beta]1 mRNA levels fall during late gestation and are not regulated by cortisol in the sheep fetus." Molecular and Cellular Endocrinology 206(1-2): 85.

McMillen, I. C. and M. B. Adams (2003). Adrenal Cortes: Role in medullary synthesis of PNMT. Encyclopedia of Hormones. H. L. Henry and A. W. Norman, Academic Press Elsevier Science. 1: 42-47.

Muhlhausler, B. S., C. T. Roberts, et al. (2003). "Determinants of Fetal Leptin Synthesis, Fat Mass, and Circulating Leptin Concentrations in Well-Nourished Ewes in Late Pregnancy." Endocrinology 144(11): 4947-4954.

Warnes, K. E., C. L. Coulter, et al. (2003). "The effect of intrafetal infusion of metyrapone on arterial blood pressure and on the arterial blood pressure response to angiotensin II in the sheep fetus during late gestation." Journal of Physiology 552(2): 621-633.

Yuen, B. S. J., P. C. Owens, et al. (2003). "Leptin alters the structural and functional characteristics of adipose tissue before birth." The FASEB Journal: 02-0756fje.
Symonds, M. E., H. Budge, et al. (2002). "Maternal nutrition, cortisol and programming of fetal development." Perinatology 4: 67-74.

Williams, S. J., I. C. McMillen, et al. (2002). "Placental Restriction Increases the Expression of Prostaglandin Endoperoxide G/H Synthase-2 and EP2 mRNA in the Fetal Sheep Kidney during Late Gestation." Pediatric Research 52(6): 879-885.

Yuen, B. S. J., P. C. Owens, et al. (2002). "Circulating Leptin Concentrations Are Positively Related to Leptin Messenger RNA Expression in the Adipose Tissue of Fetal Sheep in the Pregnant Ewe Fed at or Below Maintenance Energy Requirements During Late Gestation." Biology of Reproduction 67(3): 911-916.