Network Member Profile
|
|
Professor Eleanor Mackie
Department:
School of Veterinary Science
Organisation:
University of Melbourne
Address:
Parkville VIC 3010
Telephone: 03 8344 7360 Facsimile:
03 8344 7374
Email:
ejmackie@unimelb.edu.au
Web
Address
|
Current Field of Study
- Development and pathology of the musculoskeletal system
Australian Collaborators
- A/Prof Rob Pike, Monash University, Melbourne, Victoria
- Dr James Whisstock, Monash University, Melbourne, Victoria
- A/Prof Phil Bird, Monash University, Melbourne, Victoria
- Dr Steve Bottomley, Monash University, Melbourne, Victoria
- Dr Tim Hewitson, Royal Melbourne Hospital, Melbourne, Victoria
- Professor Leo Jeffcott, University of Sydney
- Dr Greg Harper, CSIRO Livestock Industries, Qld
- A/Prof Ross Tellam, CSIRO Livestock Industries, Qld
International Collaborators
- Dr Ruth Chiquet-Ehrismann, Friedrich Miescher Institute, Basel, Switzerland
- Dr Maria Ransjö, Department of Oral Cell Biology, Umeå University, Sweden
- Dr Richard Tucker, Dept of Cell Biology and Human Anatomy, University of California at Davis, California, USA
Facilities
- Scanning and Transmission Electron Microscopy
- Quantitative PCR
- Primary osteoblast, myoblast and chondrocyte culture
- Osteoclast differentiation and bone resorption assays
- Three-dimensional chondrocyte culture (to allow hypertrophy)
- Single muscle fibre culture
- Mineralised tissue histology
Lab Members
|
|
Prof Eleanor Mackie
|
Head of the Lab
|
|
Dr Charlie Pagel
|
Postdoctoral Fellow
|
|
Dr Lopeti Lavulo
|
Postdoctoral Fellow
|
|
Dr Sutharshani Sivaguranathan
|
Postdoctoral Fellow
|
|
Dr Michiko Mirams
|
Postdoctoral Fellow
|
|
Dr Jason White
|
Postdoctoral Fellow
|
|
Ms Liliana Tatarczuch
|
Professional Officer
|
|
Ms Su Toulson
|
Technical Officer
|
|
Mr Chris Gorman
|
PhD Student
|
|
Mr David Wong
|
PhD Student
|
|
Ms Lay Hoon Loh
|
PhD Student
|
|
Ms Rebecca Fitzpatrick
|
PhD Student
|
|
Mr Jason Chen
|
PhD Student
|
|
Ms Jin Yoo
|
PhD Student
|
| Ms Smitha Georgy |
PhD Student |
| Mr Kitipong Uaesoontrachoon |
PhD Student |
Recent Grant Income
|
|
Description
|
CIs
|
Type of Grant
|
Year
|
Income p.a.
|
| ŒStructural basis of femoral neck strength¹ |
Seeman, E., Zebaze, R.M.D., Knackstedt, M.A., Mackie, E.J.
and Price, R.I. |
NHMRC Project Grant |
2006 - 2008 |
$244,250 |
| Proteases, their inhibitors and receptors in degenerative
disease |
Whisstock JC, Bird PI, Bottomley SP, Mackie EJ, Pike RN |
NHMRC Program Grant |
2004-2008 |
$1,311,000 |
| Development of cellular resources to support expression profiling
and proteomic studies |
Mackie EJ, Pagel CN
|
MLA/AWI Sheep Genomics Program Project Grant |
2004 2005 2006 2007 |
$147,125 $78,734 $39,367 $49,366
|
Recent Publications
Hewitson, T.D., Martic, M., Kelynack, K.J., Pagel, C.N., Mackie, E.J. and Becker,
G.J. (2005) ŒThrombin is a pro-fibrotic factor for
rat renal fibroblasts in vitro.¹ Nephron Exp. Nephrol. 101: 42-49.
Song, S.-J., Pagel, C.N., Campbell, T.M., Pike, R.N. and Mackie, E.J. (2005)
‘The role of protease-activated receptor-1 in bone healing’. Am.
J. Pathol. 166:857-868.
Song, S.-J., Pagel, C.N., Pike, R.N. and Mackie, E.J. (2005) ‘Studies
on the receptors mediating responses of osteoblasts to thrombin’. Int.
J. Biochem. Cell Biol. 371:206-213.
Smith, R.A., Ransjö, M., Tatarczuch, L., Song, S.-J., Pagel, C.N., Morrison,
J.R., Pike, R.N. and Mackie, E.J. (2004) ‘Activation of protease-activated
receptor-2 leads to inhibition of osteoclast differentiation’. J Bone
Miner. Res. 19:507-516.
Mackie, E.J. (2003) ‘Osteoblasts: Novel roles in orchestration of skeletal
architecture’. Int. J. Biochem. Cell Biol. 35:1301-1305.
Pagel, C.N., de Niese, M.R., Abraham, L.A., Chinni, C., Song, S.-J., Pike,
R.N. and Mackie, E.J. (2003) ‘Inhibition of osteoblast apoptosis by thrombin’.
Bone 33:733-743.
Campbell, T.M., Wong, W.T. and Mackie, E.J. (2003) ‘Establishment of
a model of cortical bone repair in mice’. Calcif. Tissue Int. 73:49-55.
de Niese, M.R., Chinni, C., Pike, R.N., Bottomley, S.P. and Mackie, E.J. (2002)
‘Dissection of protease-activated receptor-1-dependent and –independent
responses to thrombin in skeletal myoblasts.’ Exp. Cell Res. 274:149-156.
Mackie, E.J., Pagel, C.N., Smith, R., de Niese, M., Song, S.-J. and Pike, R.N.
(2002) ‘Protease-activated receptors: a means of converting extracellular
proteolysis into intracellular signals’. IUBMB Life 53:277-281.
|
