Network Member Profile
Dr Graham Lieschke
Department:
Cancer and Haematology Division
Organisation:
Walter and Eliza Hall Institute of Medical Research
Address:
1G Royal Parade, Parkville, Victoria 3050
Telephone: 03 9342 8633 Facsimile: 03
9347 0852
Email: lieschke@wehi.edu.au
Web
Address
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Current Field of Study
- Haemopoiesis, Leukaemogenesis
Australian Collaborators
- Dr Joan Heath, Ludwig Institute for Cancer Research, Parkville, VIC
- Dr Graham Mann, Westmead Institute for Cancer Research, NSW
- Dr Stephen Nutt, Walter and Eliza Hall Institute, VIC
- Dr Benjamin Kile, Walter and Eliza Hall Institute, VIC
International Collaborators
- Dr Leonard Zon, Children’s Hospital, Boston, USA
- Dr Pier Paolo Pandolfi, Memorial Sloan Kettering Cancer Center, New York,
USA
- Dr Andrew Oates, Max Planck Institute, Dresden, Germany
- Dr Philip Crosier, University of Auckland, New Zealand
- Dr Victoria Prince, University of Chicago, Chicago USA
- Dr David Kimelman, University of Washington, Seattle, USA
Facilities
- Zebrafish Research Aquarium
Lab Members
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Dr Graham Lieschke
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Head of the Lab
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Dr Judy Layton
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Senior Investigator / Senior Scientist
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Mr John Hayman
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Research Assistant
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Mr Luke Kapitany
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Research Assistant
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Ms Sony Varma
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Research Assistant
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| Dr Duncan Carradice |
PhD Student |
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Mr Luke Pase
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PhD Student
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| Mr Felix Ellett |
PhD Student |
Recent Grant Income
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Description
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CIs
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Type of Grant
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Year
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Income p.a.
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| Senior Research Fellowship |
Lieschke GJ |
NHMRC Research Fellowship |
2007-2011 |
$116,750 |
| Discovery and analysis of vertebrate intestinal
development genes that may play a role in colon cancer |
Heath JK, Lieschke GJ, Ernst M |
NHMRC Project Grant |
2007-2010 |
$186,000-176,000 |
| Role of the microRNA miR144 in haemopoiesis in
vivo |
Lieschke GJ |
NHMRC Project Grant |
2007-2009 |
$125,625 |
| Australian Centre for Vertebrate Mutation Detection (ACVMD) |
Hilton D, Bertram E, Currie P, Forrest S, Heath J, Kile B,
Lieschke G, O'Bryan M |
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$1,600,000 over 5 years; $450,00-250,000 pa |
| Congenital myeloid failure syndromes in mutant zebrafish |
Lieschke GJ |
NIH R01 Grant |
2004-2009 |
$ US270,000 |
Recent Publications
PEER REVIEWED PUBLICATIONS
1. Mannering SI, Zhan Y, Gilbertson B, LIESCHKE GJ, Cheers C. T lymphocytes from G-CSF-/- mice produce large quantities of IFNγ in a chronic infection model. Immunology 101(1):132-9, 2000.
2. Liao EC, Paw BH, Peters LL, Zapata A, Pratt SJ, Do CP, LIESCHKE G, Zon LI. Hereditary spherocytosis in zebrafish riesling illustrates evolution of erythroid β-spectrin structure, and function in red cell morphogenesis and membrane stability. Development 127:5123-5132, 2000.
3. Sun X, Layton JE, Elefanty A, LIESCHKE GJ. Comparison of effects of the tyrosine kinase inhibitors AG957, AG490 and STI571 on BCR-ABL-expressing cells, demonstrating synergy between AG490 and STI571. Blood, 97(7);2008-2015, 2001.
4. LIESCHKE GJ, Oates AC, Crowhurst MO, Ward AC, Layton JE. Morphological and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish. Blood, 98(10);3087-3096, 2001.
5. Akbarzadeh S, McPhee DOM, Alexander WS, LIESCHKE GJ, Layton JE. Tyrosine residues of the granulocyte colony-stimulating factor receptor transmit proliferation and differentiation signals in murine bone marrow cells. Blood, 99(3);879-887, 2002.
6. LIESCHKE GJ, Oates AC, Paw BH, Thompson MA, Hall NE, Ward AC, Ho RK, Zon LI, Layton JE. Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis; implications for axial patterning. Developmental Biology, 246(2):274-295, 2002.
7. Ward AC, McPhee DO, Condron MM, Varma S, Cody SH, Onnebo SMN, Paw BH, Zon LI, LIESCHKE GJ. The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish. Blood. 102(9):3238-3240, 2003.
8. Mawdsley DJ, Cooper HM, LIESCHKE GJ, Cody SH, Heath JK. The netrin receptor, neogenin, is required for neural tube formation and somitogenesis in zebrafish. Developmental Biology , 269:302-315, 2004.
9. Hogan BM, Hunter MP, Oates AC, Crowhurst MO, Hall NE, Heath JK, Prince VE, LIESCHKE GJ. Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Developmental Biology , 276(2):508-522, 2005.
10. Hogan BM, Danks JA, Layton JE, Hall NE, Heath JK, LIESCHKE GJ. Duplicate zebrafish pth genes are expressed in the lateral line and central nervous system during embryogenesis. Endocrinology, 146(2):547-551, 2005. [with Editorial comment 146(2):544-546]
11. Onnebo SMN, Condron MM, McPhee DO, LIESCHKE GJ, Ward
AC. Hematopoietic perturbation in zebrafish expressing a tel-jak2a
fusion. Experimental Hematology, 33(2):182-188, 2005.
12. Hogan BM, Layton JE, Pyati UJ, Nutt SL, Hayman JW, Varma S, Heath JK, Kimelman
D, LIESCHKE GJ. Specification of the primitive myeloid precursor pool requires
signaling through Alk8 in zebrafish. Current Biology, 16(5):506-511, 2006.
13. Hogan BM, Pase L, Hall NE, LIESCHKE GJ. Characterisation of duplicate zinc
finger like 2 erythroid precursor genes in zebrafish. Development, Genes and
Evolution, 216(9):523-529, 2006.
14. Kinna G, Kolle G, Carter A, Key B, Perkins A, LIESCHKE GJ, Little MH. Knockdown
of zebrafish crim1 results in defects in somite and vascular development. Mechanisms
of Development, 123(4):277-287, 2006.
15. Yoong S, O'Connell B, Soanes A, Crowhurst MO, LIESCHKE GJ, Ward AC. Characterisation
of the zebrafish matrix metalloproteinase 9 gene and its developmental expression
pattern Gene Expression Patterns, in press, 2006.
16. Chee LCY, Fahey V, Juneja S, LIESCHKE GJ, Szer J. Relapsed blastic natural
killer cell leukaemia with splenic rupture. British Journal of Haematology,
2006:135;2. (Case report).
REVIEWS
LIESCHKE GJ. Zebrafish – an emerging genetic model
for the study of cytokines and hematopoiesis in the era of functional genomics.
International Journal of Hematology (invited review for “Progress
in Hematology” series) 73:23-31, 2001.
Szer J, LIESCHKE GJ. Small molecule: large hopes. Internal
Medicine Journal (invited editorial), 31:382-383, 2001.
Crowhurst MO, Layton JE, LIESCHKE GJ. Developmental biology
of zebrafish myeloid cells. International Journal of Developmental
Biology (invited contribution) 46:483-492, 2002.
Ward AC, LIESCHKE GJ. The zebrafish as a model system for
human disease. Frontiers in Bioscience 7;d827-833, 2002. (Invited
review).
Sun X, LIESCHKE GJ. Abnormal protein tyrosine kinases associated
with human haematological malignancies. Chinese Journal of Cancer Research
14(2):79-83, 2002.
LIESCHKE GJ. Animal models of hematopoietic growth factor
perturbations in physiology and pathology. In: Morstyn G, Foote MA, LIESCHKE
GJ (eds). Hematopoietic Growth Factors in Oncology: Basic Science and
Clinical Therapeutics. Part of the Cancer Drug Discovery and Development
series (Beverly A Teicher, series editor). Humana Press. Chapter 2,
pp11-44, 2004.
LIESCHKE GJ. Fluorescent neutrophils throw a spotlight on inflammation. Blood,
in press, 2006
BOOK
18. Morstyn G, Foote MA, LIESCHKE GJ (eds). Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics. Part of the Cancer Drug Discovery and Development series (Beverly A Teicher, series editor). Humana Press, 2004.
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