Network Member Profile
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Dr Michael Lardelli
Department:
School of Molecular and Biomedical Science (Genetics) and ARC Special Research Centre for the Molecular Genetics of Development
Organisation:
University of Adelaide
Address:
Molecular Life Sciences Bldg., Adelaide SA 5005
Telephone: 08 8303
3212 Facsimile:
08 8303 7534
Email:michael.lardelli@adelaide.edu.au
Web
Address
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Current Field of Study
- The genetic basis of Alzheimers disease, especially presenilin gene function
- The rostrocaudal patterning of the developing spinal cord
- Zebrafish models of human disease
- Transgenesis
Australian Collaborators
- A/Prof Robert Richards, School of Molecular and Biomedical Science, The
University of Adelaide, SA
- Dr Dan Peet, The University of Adelaide, Adelaide, SA
- Dr Josef Gecz, The Women's and Children's Hospital, Adelaide, SA
- A/Prof Ralph Martins, The University of Western Australia, Perth, WA
- Dr Simon Koblar, School of Molecular and Biomedical Science, University
of Adelaide, SA
- Dr Yeesim Khew-Goodall, Hanson Institute, IMVS, Adelaide, SA
- Dr Chris Hahn, Hanson Institute, IMVS, Adelaide, SA
- Dr Stephen Wood, Child Health Research Institure, Adelaide, SA
International Collaborators
- Andrew Oates in the laboratory of Robert Ho, University of Chicago, USA
- Randall Moon, Howard Hughes Medical Institute, University of Washington,
USA
Facilities
- Zebrafish facility
- Microarray facility
- Proteomics facility (as of 2006)
- Whole mount in situ transcript hybridisation and immunohistochemistry
- Analysis of gene expression by zebrafish microarray
- Generation of transgenic zebrafish
- Analysis of factors controlling neuronal migration by dye uncaging
- Altering gene activity by injection of morpholino oligonucleotides blocking translation or splicing
Lab Members
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Dr Michael Lardelli
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Head of the Lab
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Dr Svanhild Nornes
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Postdoctoral fellow
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Mr Simon Wells
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PhD Student
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Mr Ben Tucker
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PhD Student
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Ms Morgan Newman
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PhD Student
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| Mr Lachlan Wilson |
Honours Student (2007) |
| Mr Jason Greenslade |
Honours Student (2007) |
Recent Grant Income
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Description
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CIs
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Type of Grant
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Year
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Income p.a.
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| Truncating presenilin mutations and their effects on y-secretase
activity, tau and B-catenin. |
M Lardelli and R Martins |
NHMRC Project Grant |
2007-2009 |
$396,250 |
| Analysis of the role of presenilin transcript splicing in
Alzheimers disease using the zebrafish model |
M Lardelli |
University of Adelaide Faculty of Sciences Strategic Research
Scheme |
2006 |
$11,875 |
Recent Publications
Newman, M., Musgrave, I. and Lardelli, M. (2007) Alzheimer Disease: Amyloidogenesis,
The Presenilins and Animal Models. BBA - Molecular Basis of Disease (in press)
Tucker, B., Richards, R. and Lardelli, M. (2006) Contribution of mGluR and
Fmr1 Functional Pathways to Neurite Morphogenesis, Craniofacial Development
and Fragile X Syndrome. Human Molecular Genetics doi: 10.1093/hmg/ddl422
Tucker, B., Hepperle, C., Kortschak, B., Rainbird, B., Wells, S., Oates, A.C.
and Lardelli, M. (2006) Zebrafish Angiotensin II Receptor-like 1a (agtrl1a)
is expressed
in migrating hypoblast, vasculature, and in multiple embryonic epithelia. Gene
Expr. Pattern, doi:10.1016/j.modgep.2006.09.006
Scholpp, S., Groth, C., Lohs, C., Lardelli, M., Brand, M. (2004) Zebrafish
fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling
at the midbrain-hindbrain boundary. Development, Genes and Evolution 214: 285-95
Tucker, B., Richards, R., Lardelli, M. (2004) Expression of three zebrafish
orthologs of human FMR1-related genes and their phylogenetic relationships.
Development, Genes and Evolution 214: 567-74
Camp, E.C., Hope, R., Kortschak, R.D., Cox, T.C., Lardelli, M.T. (2003) Expression
of three spalt (sal) gene homologues in zebrafish embryos.
Development, Genes and Evolution. 213:35-43
Camp, E., Badwhar, P., Mann, G., Lardelli, M. (2003) Expression analysis of
a tyrosinase promoter sequence in zebrafish. Pigment Cell Research 16: 117-26
Lardelli, M. (2003) Something fishy in 21st century genomics. Today's Life
Science (2003) 15: 20-23.
Nornes, S., Groth, C., Camp, E., Ey, P. and Lardelli, M. (2003) Developmental
control of Presenilin1 expression, endoproteolysis and interaction in zebrafish
embryos. Exp. Cell Res. 289:124-132.
Lardelli, M. (2003) The evolutionary relationships of zebrafish genes tbx6,
tbx16/spadetail and mga. Dev. Genes Evol. 213: 519-522.
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