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Network Member Profile

Current Field of Study

• Sex Determination and Gonadal Development
• Sox Gene Function and Evolution
• Molecular Genetics of Vascular Development
• Development of Germ Cells

Australian Collaborators

• Prof George Muscat, IMB, Brisbane, Qld
• Dr Melissa Little, IMB, Brisbane, Qld
• Dr Kate Loveland, IRD, Melbourne, Vic
• Dr Moira O’Bryan, IRD, Melbourne, Vic
• Dr Paul Hetzog, IRD, Melbourne, Vic
• Prof John Aitken, Uni of Newcastle, Newcastle, NSW
• Dr Andrew Sinclair, Murdoch Children's Research Institute, Melbourne, Vic
• Dr Vincent Harley, PHIMR, Melbourne, Vic
• Prof Patrick Tam, CMRI, Sydney, NSW
• Dr Marc Achen and Dr Steven Stacker, Ludwig Institute, Melbourne
• Professor Bernie Degnan, University of Queensland
• Dr Frank Gruetzner, University of Adelaide
• Dr Sigrid Lehnert, CSIRO, Brisbane
• Professor David Jans, Monash University
• Professor John Mattick, IMB, Brisbane
• Dr Moira O'Bryan, Monash University
• Professor Rob Parton, IMB, Brisbane
• Dr Ron Thresher and Dr Jawahar Patil, CSIRO, Hobart
• Dr Paul Thomas, University of Adelaide
  

International Collaborators

• Dr Eva Eicher, Jackson Laboratories, USA
• Dr Yuji Mishina, National Institutes of Health, North Carolina, USA
• Drs Masami Kanai-Azuma and Yoshiakira Kanai, University of Tokyo, Japan
• Professor Kathy Cheah, University of Hong Kong
• Dr Blanche Capel, Duke University Medical centre, North Carolina, USA
• Dr Yuji Mishina, NIH, USA
• Dr Elisabetta Dejana, University of Milan
• Dr David Bornholt and Dr Tim King, US Geological Survey
• Dr Monika Ward, University of Hawaii
• Professor Michael Wegner, University of Erlangen, Germany
• Dr Gen Yamada, Kumamoto University
  

Facilities

• SRC Microarray facility
• SRC protein expression facility
• Transgenic Animal Service of Queensland
• Confocal and Electron Microscopy facilities

Recent Publications

Wilhelm, D, Palmer, S and Koopman, P (2006). Sex determination and gonadal development in mammals. Physiological Reviews, in press.

Svingen, T and Koopman, P. Involvement of homeobox genes in mammalian sexual development. Sexual Development, in press.

Knower, KC, Sim, H, McClive, PJ, Bowles, J, Koopman, P, Sinclair, AH and Harley, VR. Characterisation of urogenital ridge gene expression in the human embryonic carcinoma cell line NT2/D1. Sexual Development, in press.

Young, N and Koopman, P. Sox genes at the heart of endothelial transcription. In: "Endothelial Biomedicine" (W. Aird, ed.). Cambridge University Press, in press.

Wilhelm, D and Koopman, P (2006). The makings of maleness: Towards an integrated view of male sexual development. Nature Reviews Genetics 7:620-631.

Young, N, Hahn, CN, Poh, A, Dong, C, Wilhelm, D, Olsson, J, Muscat, GEO, Parsons, P, Gamble, JR and Koopman, P (2006). Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. Journal of the National Cancer Institute 98: 1060-1067.

Matsui, T, Kanai-Azuma, M, Hara, K, Matoba, S, Hiramatsu, R, Kawakami, H, Kurohmaru, M, Koopman, P, and Kanai, Y (2006). Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. Journal of Cell Science 119:3513-3526.

Polanco, JC and Koopman, P. Sry and the hesitant beginnings of male development. Developmental Biology, epub 24 August.

Bowles, J, Knight, D, Smith, C, Wilhelm, D, Richman, J, Mamiya, S, Yashiro, K, Chawengsaksophak, K, Wilson, MJ, Rossant, J, Hamada, H and Koopman, P (2006). Retinoid signaling determines germ cell fate in mice. Science 312: 596-600.

Koopman, P and Wilhelm, D (2006). Gonadal sex determination and differentiation. In: Encyclopedia of Life Science, John Wiley and Sons, Chichester, UK, doi: 10.1038/npg.els.0004361.

Wilhelm, D, Huang, E, Svingen, T, Stanfield, S, Dinnis, D and Koopman, P (2006). Comparative proteomic analysis to study molecular events during gonad development in mice. genesis 44:168-176.

Holt, JE, Jackson, A, Roman, SD, Aitken, RJ, Koopman, P and McLaughlin, EA (2006). CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary. Developmental Biology 293: 449-460.

Wilson, MJ, Bowles, J and Koopman, P (2006). The matricellular protein SPARC is internalized in Sertoli, Leydig, and germ cells during testis differentiation. Molecular Reproduction and Development, 73(5):531-539.??

Beverdam, A and Koopman, P (2006). Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes. Human Molecular Genetics 15: 417-431.

Bullejos, M, and Koopman, P (2005). Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-YDOM sex reversal. Developmental Biology 278: 473 - 481.

Wilson, MJ, Jeyasuria, P, Parker, KL and Koopman, P (2005). The transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development. J. Biol. Chem. 280: 5917-5923.

Koopman, P (2005). Sex determination: A tale of two Sox genes. Trends in Genetics 21: 367-370.

Wilson, MJ, Liaw, L and Koopman, P (2005). Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development. Developmental Dynamics 233: 1488-1495.

Takada, S, Mano, H and Koopman, P (2005). Regulation of Amh during sex determination in chickens: Sox gene expression in male and female gonads. Cellular and Molecular Life Sciences 62: 2140-2146.

Jeanes, A, Wilhelm, D, Wilson, MJ, Bowles, J, McClive, PJ, Sinclair, AH and Koopman, P (2005). Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis. Reproduction 130: 509-516.

Browne, CM, Hime, GR, Koopman, P and Loveland, KL (2005). Genetic basis of human testicular germ cell cancer: insights from the fruitfly and mouse. Cell and Tissue Research 322: 5-19.

Loffler KA, Combes AN, Wilhelm D, Beverdam A, Bowles J and Koopman P. (2005). Pisrt1, a gene implicated in XX sex reversal, is expressed in gonads of both sexes during mouse gonad development. Molecular Genetics and Metabolism 86: 286-292.

Wilhelm, D, Martinson, F, Bradford, S, Wilson, M, Combes, A, Beverdam, A, Bowles, J, Mizusaki, H and Koopman, P (2005). Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signalling during mammalian sex determination. Developmental Biology 287: 111-124.

Hargrave, M, Bowles, J and Koopman, P (2005). In situ hybridization of whole-mount embryos. In: IA Darby, T Hewitson, eds. In Situ Hybridization Protocols, 3rd ed (Methods in Molecular Biology, Vol. 326). Humana Press, Totowa, NJ. ISBN 1-58829-402-1. pp. 103-114.

Aitken RJ, Koopman P, Lewis SE. (2004) Seeds of concern. Nature. 2004 Nov 4;432(7013):48-52.

Bullejos M, Koopman P. (2004) Germ cells enter meiosis in a rostro-caudal wave during development of the mouse ovary. Mol Reprod Dev. 2004 Aug;68(4):422-8.

Dong C, Wilhelm D, Koopman P. (2004) Sox genes and cancer. Cytogenet Genome Res. 2004;105(2-4):442-7.

Koopman P, Schepers G, Brenner S, Venkatesh B. (2004) Origin and diversity of the SOX transcription factor gene family: genome-wide analysis in Fugu rubripes. Gene. 2004 Mar 17;328:177-86.

Smith JM, Bowles J, Wilson M, Koopman P. (2004) HMG box transcription factor gene Hbp1 is expressed in germ cells of the developing mouse testis. Dev Dyn. 2004 Jun;230(2):366-70.

Smith JM, Bowles J, Wilson M, Teasdale RD, Koopman P. (2004) Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Gene Expr Patterns. 2004 Oct;4(6):701-5.

Smith JM, Koopman PA. (2004) The ins and outs of transcriptional control: nucleocytoplasmic shuttling in development and disease. Trends Genet. 2004 Jan;20(1):4-8. Review.

Takada S, DiNapoli L, Capel B, Koopman P. (2004) Sox8 is expressed at similar levels in gonads of both sexes during the sex determining period in turtles. Dev Dyn. 2004 Oct;231(2):387-95.

James, K, Hosking, B, Gardner, J, Muscat, GEO and Koopman, P (2003). Sox18 is mutated in ragged-like and opossum mice. genesis 36: 1–6.

Loffler, KA, Zarkower, D and Koopman, P (2003). Etiology of ovarian failure in blepharophimosis-ptosis-epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development. Endocrinology 144: 3237–3243.

Schepers, G, Wilson, M, Wilhelm, D and Koopman, P (2003). SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro. J. Biol. Chem . 278: 28101–28108.

Koopman, P (2003). Gender benders. Nature News and Views, 20 November 2003.

Schepers, GE, Teasdale, RD and Koopman, P (2002). Twenty pairs of Sox: Extent, homology and nomenclature of the mouse and human Sox transcription factor gene families. Developmental Cell 3: 167–170.

Bullejos, M, Bowles, J and Koopman, P (2002). Extensive vascularization of developing mouse ovaries revealed by caveolin-1 expression. Developmental Dynamics 225: 95–99.

Koopman, P (2001). The genetics and biology of vertebrate sex determination. Cell 105: 843–847.