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Network Member Profile

Current Field of Study

• Fetal lung growth and development

Australian Collaborators

• Prof Richard Harding, Department of Physiology, Monash University, Melbourne, VIC
• Dr. Tim Cole, Department of Biochemistry, Melbourne University, Melbourne, VIC
• Dr. Amanda Fosang, Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, VIC
• Prof Colin Morley, Neonatal Medicine, Royal Women’s Hospital, Melbourne, VIC
• Dr. Peter Dargaville, Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, VIC
• A/Prof. Chris Daniels, Department of Environmental Biology, The University of Adelaide, Adelaide, SA
• Dr. Sandra Orgeig, Department of Environmental Biology, The University of Adelaide, Adelaide, SA

International Collaborators

• Dr B Piedboeuf, Perinatal Research Unit, Laval university, Quebec, Canada
• Professor David Olsen, Perinatal Research Centre, Edmonton, Canada
• Professor Fred Possmayer, O&G, University of Western Ontario, Canada

Facilities

• Mouse Transgenic Facility

Recent Publications

Sozo F., Wallace M.J., Filby C.E., Zahra V.A. and Hooper S.B. (2006). Gene expression profiling during increased fetal lung expansion identifies genes likely to regulate development of the distal airways. Physiological Genomics 24:105-113.

Hooper, S.B. and Wallace, M.J. (2006) Role of the Physicochemical environment in lung development. Clinical and Experimental Pharmacology and Physiology. 33:273-279.

Filby C.E., Hooper S.B., Sozo F, Zahra V.A. and Wallace M.J. (2006) VDUP1, a potential regulator of lung growth and maturation in the ovine fetus. American Journal of Physiology. 290: L250-L258

Cock, M.L., Hanna, M., Sozo F., Wallace, M.J. Yawno, T., Suzuki K., Maritz G., R. Harding and Hooper S.B. (2005). Pulmonary function and structure following mild preterm birth in lambs. Pediatric Pulmonology 40:336-348

Hooper, S.B. and Harding, R. (2005) Role of aeration in the physiological adaptation of the lung to air-breathing at birth. Current Respiratory Medicine Reviews 1(2): 185-195.

Kitchen MJ, Lewis RA, Yagi N, Uesugi K, Paganin D, Hooper SB, Adams G, Jureczek S, Singh J, Christensen C, Phufton A, Hall CJ, Cheung KC, Pavlov KM. (2005). Phase contrast X-ray imaging of mice and rabbit lungs: a comparative study. British Journal of Radiology 78: 1018-1027.

Polglase, G., Morley, C.J., Crossley, K., Dargaville, P.A., Harding, R. Morgan, D. and Hooper S.B. (2005). Positive end expiratory pressures differentially alter pulmonary hemodynamics and oxygenation in preterm lambs. Journal of Applied Physiology 99: 1453-1461.

Lewis, R.A., Yagi, N., Kitchen, M.J., Morgan, M.J., Paganin, D., Siu, K.K.W., Williams, I., Uesugi, K., Wallace, M.J. Hall, C.J., Whitley, J. and Hooper, S.B. (2005). Dynamic imaging of the lungs using X-ray phase contrast. Physics in Medicine and Biology. 50:3031-3040.

Probyn, M.E, Hooper, S.B., Dargaville, P.A, McCallion, Harding, R., Morley, C.J. (2005) Effects of tidal volume and positive end expiratory pressure during resuscitation of very premature lambs. Acta Pediatrica 94:1764-70.

Boland R, Joyce BJ, Wallace MJ, Stanton H, Fosang AJ, Pierce RA, Harding R, Hooper SB. (2004) Cortisol enhances structural maturation of the hypoplastic fetal lung in sheep. J Physiol. 2004 Jan 15;554(Pt 2):505-17.

Cock ML, Joyce BJ, Hooper SB, Wallace MJ, Gagnon R, Brace RA, Louey S, Harding R. (2004) Pulmonary elastin synthesis and deposition in developing and mature sheep: effects of intrauterine growth restriction. Exp Lung Res. 2004 Jul-Aug;30(5):405-18.

Cole TJ, Solomon NM, Van Driel R, Monk JA, Bird D, Richardson SJ, Dilley RJ, Hooper SB. (2004) Altered epithelial cell proportions in the fetal lung of glucocorticoid receptor null mice. Am J Respir Cell Mol Biol. 2004 May;30(5):613-9.

Flecknoe SJ, Boland RE, Wallace MJ, Harding R, Hooper SB. (2004) Regulation of alveolar epithelial cell phenotypes in fetal sheep: roles of cortisol and lung expansion. Am J Physiol Lung Cell Mol Physiol. 2004 Dec;287(6):L1207-14.

Polglase GR, Wallace MJ, Grant DA, Hooper SB. (2004) Influence of fetal breathing movements on pulmonary hemodynamics in fetal sheep. Pediatr Res. 2004 Dec;56(6):932-8.

Probyn ME, Hooper SB, Dargaville PA, McCallion N, Crossley K, Harding R, Morley CJ. (2004) Positive end expiratory pressure during resuscitation of premature lambs rapidly improves blood gases without adversely affecting arterial pressure. Pediatr Res. 2004 Aug;56(2):198-204.

Suzuki K, Hooper SB, Cock ML, Harding R. (2005) Effect of Lung Hypoplasia on Birth-Related Changes in the Pulmonary Circulation in Sheep. Pediatr Res. 2005 Apr;57(4):530-6.

Joyce, B.J., Wallace, M.J., Harding, R. And Hooper, S.B. (2003) Sustained changes in lung expansion alter tropoelastin mRNA levels and elastin content in fetal sheep lungs. American Journal of Physiology 284: L643-649.

Flecknoe, S., Wallace, M.J., Cock, M.L., Harding, R. and Hooper, S.B. (2003). Changes in alveolar epithelial cell proportions during late gestation and after birth in sheep. American Journal of Physiology 285: L664-L670.

Liu, H., Hooper, S.B., Armugan, A., Dawson, N., Ferraro, T., Jeyaseelan, K., Thiel, A., Koukoulas, I. and Wintour, E.M. (2003) Aquaporin gene expression and regulation in the ovine fetal lung. Journal of Physiology 2003; 551(Pt2):503-14.

BOOKS:

Hooper, S.B. and Wallace, M.J. Role of physical, endocrine and growth factors in lung development. In: The lung: development, aging and the environment. Eds. R. Harding, K. Pinkerton and C. Plopper. Academic Press, Cambridge. (In press)

Hooper, S.B. and Harding, R. Pulmonary transition at birth. In: The lung: development, aging and the environment. Eds. R. Harding, K. Pinkerton and C. Plopper. Academic Press, Cambridge. (In press)

Harding, R. and Hooper, S.B. Physiologic mechanisms of normal and altered lung growth. In: Fetal and Neonatal Physiology, 3 rd Edition. Eds. Polin, Fox & Abman. Harcourt Health Sciences, Philadelphia. (In press).

Harding, R., Cock, M.L., Joyce, B.J., Louey,S., Wignarajah, D., Suzuki, K., Albuquerque, C.A., Maritz G., Wallace, M.J. and Hooper, S.B. (2003) Immediate and long-term consequences of induced low birth weight in sheep. In: Comparative Neonatology and Perinatology, Havemeyer Foundation Monograph Series No. 8. Eds P. Sibbons, L. Foster and J.F. Wade. R&W Publications, UK. 29-31.