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Network Member Profile

Current Field of Study

• Developmental biology (organogenesis of the vertebrate intestine)
• Colorectal cancer

Australian Collaborators

• Dr. Graham Lieschke, Walter and Eliza Hall Institute, Melbourne, Victoria
• Assoc. Prof Peter Currie, Victor Chang Cardiac Research Institute, Sydney, NSW
• Assoc. Prof Matthias Ernst, Ludwig Institute for Cancer Research, Melbourne, Victoria
• Dr Heather Verkade, Department of Genetics, Monash University, Clayton, Victoria
• Dr. Robert Ramsay, Peter MacCallum Cancer Centre, Melbourne, Victoria
• Professor Rob Parton, Institute of Molecular Bioscience, St. Lucia, University of Queensland
• Professor Frank Caruso, Department of Chemical and Biomolecular Engineering, University of Melbourne
  

International Collaborators

• Professor Didier Stainier, University of California (UCSF), San Francisco, California, USA
• Assoc. Prof Bruce Appel, Vanderbilt University, Nashville, Tennessee, USA
• Professor Philip Crosier, University of Auckland, New Zealand
• Assoc. Prof Iain Shepherd, Emory University, Atlanta, Georgia, USA
  

Facilities

• Zebrafish aquarium
• Transgenic/Knock-out Mouse facility
• Centre for Advanced Microscopy (fluorescence microscopy, confocal microscopy, live time-lapse imaging, two-photon microscopy, FRET, FLIM)
  

Recent Publications

Wilkins SJ, Yoong S, Verkade H, Mizoguchi T, Plowman SJ, Hancock JF, Kikuchi Y, HEATH JK, Perkins AC (2007). Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation. Dev Biol. 314: 12-22.

Dworkin S, HEATH JK, deJong-Curtain TA, Hogan BM, Lieschke GJ, Malaterre J, Ramsay RG, Mantamadiotis T (2007). CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish. Dev Biol: 307: 127-41

Mallegol J, Van Niel G, Lebreton C, Lepelletier Y, Candalh C, Dugave C, HEATH JK, Raposo G, Cerf-Bensussan N, Heyman M (2007). T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells. Gastroenterology 132: 1866-76.

Flentjar N, Chu PY, Ng AY, Johnstone CN, HEATH JK, Ernst M, Hertzog PJ, Pritchard MA (2007).
TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient mice.
Gastroenterology 132:1410-9.

Malaterre J, Carpinelli M, Ernst M, Alexander W, Cooke M, Sutton S, Dworkin S, HEATH JK, Frampton J, McArthur G, Clevers H, Hilton D, Mantamadiotis T, Ramsay RG. (2007). c-Myb is required for progenitor cell homeostasis in colonic crypts. Proc Natl Acad Sci U S A. 104:3829-34

Lee JW, Epardaud M, Sun J, Becker JE, Cheng AC, Yonekura AR, HEATH JK, Turley SJ. (2007). Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self.
Nat Immunol. 8:181-90.

Hogan BM, Layton JE, Pyati UJ, Nutt Sl, Hayman JW, Varma S, HEATH JK, Kimelman D, Lieschke GJ (2006). Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish. Current Biology 16: 506-511

Ng ANY, de Jong-Curtain TA, Mawdsley DJ, White SJ, Shin J, Appel B, Si Dong PD, Stainier DYR and HEATH JK (2005). Formation of the digestive system in zebrafish. III. Intestinal epithelium morphogenesis. Developmental Biology 286:114-135

Cody SH, Xiang S, Layton M, Handman E, Lam M, Layton JE, Nice EC, HEATH JK (2005). A simple method allows DIC imaging in conjunction with confocal microscopy. Journal of Microscopy 217:265-74

Hogan BM, Danks JA, Layton JE, Hall NE, HEATH JK and Lieschke GJ (2005). Duplicate zebrafish pth genes are expressed in the lateral line and central nervous system during embryogenesis. Endocrinology 146:547-551. Accompanied by a News and Views article, Endocrinology, 146:544-546

Abud HE, Watson N and HEATH JK (2005). Growth of intestinal epithelium in organ culture is dependent on EGF signalling. Exp Cell Res, 303:252-262

Hogan BM, Hunter MP, Oates AC, Crowhurst MO, Hall NE, HEATH JK, Prince VE and Lieschke GJ (2004). Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Developmental Biology 276:508-22

Abud HE, Lock P and HEATH JK (2004). Efficient gene transfer into the epithelial cell layer of embryonic mouse intestine using low voltage electroporation. Gastroenterology 126:1779-1787

Miller ME, Michaylira CZ, Simmons JG, Ney DM, Dahly EM, HEATH JK and Lund PK (2004). Suppressor of cytokine signalling-2: a growth hormone inducible inhibitor of intestinal epithelial cell proliferation. Gastroenterology 127:570-581

Ramsay RG, Micallef SJ, Williams B, Lightowler S, HEATH JK, Mantamadiotis T and Bertoncello I (2004). Colony-stimulating factor-1 promotes clonogenic growth of normal murine colonic crypt epithelial cells in vitro. J. Interferon and Cytokine Res 24:416-427

Abud HE and HEATH JK (2004). Detecting apoptosis during the formation of polarized intestinal epithelium in organ culture. Cell Death and Differentiation 11:788-789
Mawdsley DJ, Cooper HM, Hogan BM, Cody SH, Lieschke GJ and HEATH JK (2004). The Netrin receptor, Neogenin, is required for neural tube formation and somitogenesis in zebrafish. Developmental Biology 269:302-315