You are here: NGED > Research Portfolio - Members

Network Member Profile

Current Field of Study

• Cardiac and skeletal muscle development
• Genetic basis of congenital heart disease
• Cardiac stem cells and regeneration

Australian Collaborators

• Prof Michael Feneley, Victor Chang Cardiac Research Institute, Darlinghurst, NSW
• Dr Diane Fatkin, Victor Chang Cardiac Research Institute, Darlinghurst, NSW
• Dr David Winlaw, The Children’s Hospital at Westmead, Westmead, NSW
• Dr Andrew Perkins, Monash University, Clayton, Vic
• Prof Edna Hardeman, Children’s Medical Research Institute, Westmead, NSW
• A/Prof Chris Moran, University of Sydney, NSW
• Dr Sally Dunwoodie, Victor Chang Cardiac Research Institute, Sydney, NSW

International Collaborators

• Prof Tim Mohun, National Institute of Medical Research, London, UK
• Dr Shahragim Tajbakhsh, Pasteur Institute, Paris, France
• Prof Lee Adamson, Samual Lunenfeld Research Institute, Toronto, Canada
• Prof David Brook, University of Nottingham, Nottingham, UK
• Prof Kimitoshi Nakamura, Kumamoto University School of Medicine, Japan
• Prof John Waddington, Royal College of Surgeons in Ireland, Dublin, Ireland
• Prof Doug Falls, Emory University, Atlanta, Georgia, USA
• Prof Elizabeth Robertson, Harvard University, Cambridge Massachusetts, USA
• Prof Michael Kuehn, National Cancer Institute, National Institutes of Health, Bethesda USA
• Prof Nadia Rosenthal, EMBL Program in Mouse Biology, Monterotondo, Italy
• Dr Benoit Bruneau, Hospital for Sick Children, Toronto, Canada
• Prof Hiroshi Hamada, Osaka University, Osaka, Japan
• Prof Michael Bates, Cincinnati Children’s Hospital Medical Centre, Cincinnati, USA
• Dr Eva Chin, Pfizer Global Research and Development, Groton, Connecticut, USA
• Dr Vincent Christoffels, Academic Medical Centre, Amsterdam, The Netherlands

Facilities

• Microarray
• Gene targeting technology
• Mouse embryo culture
• Fluorescence microscopy
• Cardiac functional analysis in mice
• Chromatin IP

Recent Publications

O'Tuathaigh CM, O'Sullivan GJ, Kinsella A, Harvey RP, Tighe O, Croke DT, Waddington JL. Sexual dimorphism changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice. Neuroreport 2006; 17(1):79-83. [IF 2.35]

Mikhalkevich N, Becknell B, Caligiuri MA, Bates MD, Harvey RP, Zheng WP. Responsiveness of Naïve CD4 T Cells to Polarizing Cytokines Determines the Ratio of Th1 and Th2 Cell Differentiation. Journal of Immunology 2006; 176(3):1553-60. [IF 6.49]

Elliott DA, Solloway MJ, Wise N, Biben C, Costa M, Furtado MB, Lange M, Dunwoodie S, Harvey RP. A Tyrosine-Rich Domain Within Homeodomain Transcription Factor Nkx2-5 is an Essential Element in the Early Cardiac Transcriptional Regulatory Machinery. Development 2006; 133:1311-1322 [Journal Cover]. [IF 7.15]

Vermont J, Garnier J-M, Dierich A, Niederreither K, Harvey RP, Chambon P, Dolle P. A conditional (loxP-flanked) allele for the gene encoding the retinoic acid-synthesizing enzyme retinoic acid-synthesizing enzyme (RALDH2). Genesis 2006; 44:155-158. [IF 2.491]

Kirk EP, Hyan C, Martin ICA, Biben C, Thomson PC, Buckley MF, Moran C, Harvey RP. Quantitative trait loci modifying cardiac atrial septal morphology and risk of patent foramen ovale in the mouse. Circulation Research 2006; 98:651-658. [IF 9.97]

Christoffels VM, Mommersteeg MTM, Trowe M-O, Prall O, de Gier-de Vries C, Soufan AT, Bussen M, Schuster-Gossler K, Harvey RP, Moorman AFM, Kispert A. Formation of the venous pole of the heart from an Nkx2-5-negative cell population requires Tbx18. Circulation Research [in press - 9 May 2006]. [IF9.97]

Bates MD, Dunagan DT, Welch LC, Kaul A and Harvey RP. The Hlx Homeobox Transcription Factor is Required Early in Enteric Nervous System. BMC Developmental Biology 2006, 6:33 - 19 July 06.

Karl T, Duffy L, Scimone A, Harvey RP, Schofield P. The heterozygous neuregulin 1 knockout mouse - an animal model for schizophrenia? Schizophrenia Research. 2006 [submitted].

Gue G, Costa MW, Otway R, Castro ML, Baddeley O, Crotty H, Yeoh T, Riek, P, Cochrane N, Semsarian C, Weintraub RG, Haywood C, Keogh A, McDonald P, Harvey RP, Fatkin D. Phenotypic spectrum of mutations in the cardiac transcription factor, NKX2.5, includes adult-onset dilated cardiomyopathy with conduction-system disease. [In preparation].

Mommersteeg MTM, Hoogaars WMH, Prall OWJ, Barnett P, de Gier-de Vries C, Papaioannou VE, Brown NA, Harvey RP, Moorman AFM, Christoffels VM. Molecular mechanisms in the localized formation of the sinuatrial node. [Submitted September 2006].

Esposito G, Grutter G, Drago F, Costa MW, De Santis A, Bosco G, Marino B, Bellacchio1 E, Lepri F, Harvey RP, Sarkozy A, Dallapiccola B. Atrio-Ventricular Accessory Pathways and Wolff-Parkinson-White Syndrome: Candidate Gene Analysis in a Wide Cohort of Patients [submitted Sept 2006]

Mommersteeg MTM, Hoogaars WMH, Prall OWJ, de Gier-de Vries C, Wiese C, Papaioannou VE, Brown NA, Harvey RP, Moorman AFM, Christoffels VM. Molecular pathway for the localized formation of the sinoatrial node [submitted Sept 2006]

Stennard F, Harvey RP. T-box Transcription Factors and Their Roles in Regulatory Hierarchies in the Developing Heart. Development 2005; 132:4897-10.

Schindeler A, Lavulo L, Harvey RP. Muscle Costameric Protein, Chisel/Smpx, Associates with Focal Adhesion Complexes and Modulates Cell Spreading In Vitro Via a Rac1/p38 Pathway. Experimental Cell Research 2005; 307:367-80.

Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP. (2005) Murine cardiac T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaption. Development 2005 May;132(10):2451-62.

von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL. (2004) Foxh1 is essential for development of the anterior heart field. Dev Cell. 2004 Sep;7(3):331-45.

Elliott DA, Kirk E, Yeoh T, Chander S, McKenzie F, Taylor P, Grossfeld P, Fatkin D, Jones O, Hayes P, Feneley, M, Harvey RP. (2003) NKX2-5 Mutations and Congenital Heart Disease: Associations with ASD and Hyperplastic Left Heart Syndrome. Journal of the American College of Cardiology 2003; 41:2072-2076.

Stennard FA, Costa MW, Elliott DA, Rankin S, Haast, SJP, Lai D, McDonald PA, Niederreither K, Dolle P, Bruneau BG, Zorn AM, Harvey RP. (2003) Cardiac T-box Factor Tbx20 Directly Interacts with Nkx2-5, GATA4 and GATA5 in Regulation of Gene Expression in the Developing Heart. Developmental Biology 2003; 262(2):206-24.

Tarlinton D, Light A, Metcalf D, Li R, Harvey RP, Robb L. (2003) Defects in splenic architecture in Nkx2-3-deficient mice are intrinsic and affect both B cell maturation and T cell dependent immune responses. Journal of Immunology 2003; 170:4002-4010.

Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay J, Novotny J, Schwartz RJ, Harvey RP, Mullins MC, Epstein JA. (2002) Hop is an Unusual Homeobox Gene that Modulates Cardiac Development. Cell 2002; 110:713-723.

Stanley E, Biben C, Elefanty A, Barnett L, Koentgen F, Robb L, Harvey RP. (2002) Efficient cre-mediated deletion in cardiac progenitor cells conferred by a 3’utr-IRES-cre allele of the homeobox gene Nkx2-5. International Journal of Developmental Biology 2002; 46:431-439.

Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, Hjaltason O, Birgisdottir B, Jonsson H, Gudnadottir VG, Gudmundsdottir E, Bjornsson A, Ingvarsson B, Ingason A, Sigfusson S, Hardardottir H, Harvey RP, Lai D, Zhou M, Brunner D, Mutel V, Gonzalo A, Lemke G, Sainz J, Johannesson G, Andresson T, Gudbjartsson D, Manolescu A, Frigge ML, Gurney ME, Kong A, Gulcher JR, Petursson H, Stefansson K. (2002) Neuregulin 1 and Susceptibility to Schizophrenia. American Journal of Human Genetics 2002; 71:877-892.