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Network Member Profile

Current Field of Study

• The effects of preterm birth on lung development, postnatal growth, and cardiovascular development.
• The effects of intrauterine growth restriction on lung development and cardiovascular development after birth.
• The development of the fetal brain: effects of intra-uterine hypoxia, infection and alcohol exposure.
  

Australian Collaborators

• A/Prof Stuart Hooper, Department of Physiology, Monash University, Melbourne, VIC
  
• A/Prof David Walker, Dept of Physiology, Monash University, VIC
• Dr Jane Black, Dept of Anatomy and Cell Biology, Monash University, VIC
• A/Prof Sandra Rees, Dept of Anatomy and Cell Biology, Melbourne University, Melbourne, VIC
• Dr Rosemary Horne, Dept. of Paediatrics, Monash Medical Centre, Clayton, VIC
• Prof Colin Morley, Neonatal Medicine, Royal Women's Hospital, Melbourne, VIC
• Dr Tim Moss, School of Womens and Infants Health, University of Western Australia, Perth, W.A.
• Dr Ken Snibson, School of Veterinary Science, University of Melbourne, VIC
• Dr Bruce Thompson, Dept of Respiratory Medicine, Alfred Hospital, Melbourne, VIC
  

Facilities

• Fetal catheterisation and physiological monitoring
• In vivo manipulation of placental function and fetal growth
• Analysis of lung structure and ultrastructure during development
• Analysis of fetal brain development following intra-uterine exposures
• Physiological studies of low birthweight (IUGR or premature) lambs
• Assessment of regional blood flow in vivo
• Ventilation and respiratory function of very premature lambs
• Postnatal follow-up studies of cardio-respiratory functions

Recent Publications

Albuquerque CA, Smith KR, Johnson C, Chao R, Harding R. (2004) Influence of maternal tobacco smoking during pregnancy on uterine, umbilical and fetal cerebral artery blood flows. Early Hum Dev. 2004 Oct;80(1):31-42.

Camm EJ, Harding R, Lambert GW, Gibbs ME. (2004) The role of catecholamines in memory impairment in chicks following reduced gas exchange in ovo. Neuroscience. 2004;128(3):545-53.

Cheung CY, Bogic L, Gagnon R, Harding R, Brace RA. (2004) Morphologic alterations in ovine placenta and fetal liver following induced severe placental insufficiency. J Soc Gynecol Investig. 2004 Dec;11(8):521-8.

Duncan JR, Camm E, Loeliger M, Cock ML, Harding R, Rees SM. (2004) Effects of umbilical cord occlusion in late gestation on the ovine fetal brain and retina. J Soc Gynecol Investig. 2004 Sep;11(6):369-76.

Duncan JR, Cock ML, Harding R, Rees SM. (2004) Neurotrophin expression in the hippocampus and cerebellum is affected by chronic placental insufficiency in the late gestational ovine fetus. Brain Res Dev Brain Res. 2004 Nov 25;153(2):243-50.

Duncan JR, Cock ML, Loeliger M, Louey S, Harding R, Rees SM. (2004) Effects of exposure to chronic placental insufficiency on the postnatal brain and retina in sheep. J Neuropathol Exp Neurol. 2004 Nov;63(11):1131-43.

Flecknoe SJ, Boland RE, Wallace MJ, Harding R, Hooper SB. (2004) Regulation of alveolar epithelial cell phenotypes in fetal sheep: roles of cortisol and lung expansion. Am J Physiol Lung Cell Mol Physiol. 2004 Dec;287(6):L1207-14.

Cock ML, Joyce BJ, Hooper SB, Wallace MJ, Gagnon R, Brace RA, Louey S, Harding R. (2004) Pulmonary elastin synthesis and deposition in developing and mature sheep: effects of intrauterine growth restriction. Exp Lung Res. 2004 Jul-Aug;30(5):405-18.

Horne RS, Parslow PM, Harding R. (2004) Respiratory control and arousal in sleeping infants. Paediatr Respir Rev. 2004 Sep;5(3):190-8. Review.

Parslow PM, Cranage SM, Adamson TM, Harding R, Horne RS. (2004) Arousal and ventilatory responses to hypoxia in sleeping infants: effects of maternal smoking. Respir Physiol Neurobiol. 2004 Apr 20;140(1):77-87. Erratum in: Respir Physiol Neurobiol. 2004 Oct 12;143(1):99. Parsiow, PM [corrected to Parslow, PM].

Parslow PM, Harding R, Adamson TM, Horne RS. (2004) Effects Of sleep state and postnatal age on arousal responses induced by mild hypoxia in infants. Sleep. 2004 Feb 1;27(1):105-9.

Probyn ME, Hooper SB, Dargaville PA, McCallion N, Crossley K, Harding R, Morley CJ. (2004) Positive end expiratory pressure during resuscitation of premature lambs rapidly improves blood gases without adversely affecting arterial pressure. Pediatr Res. 2004 Aug;56(2):198-204. Epub 2004 Jun 04.

Rees S, Harding R. (2004) Brain development during fetal life: influences of the intra-uterine environment. Neurosci Lett. 2004 May 6;361(1-3):111-4. Review.

Louey S., Cock M.L. and Harding R. (2003) Postnatal development of arterial pressure: influence of the intrauterine environment. Archives of Physiology and Biochemistry 111, 53-60.

Joyce B.J., Wallace M.J., Harding R. and Hooper S.B. (2003) Sustained changes in lung expansion alter tropoelastin mRNA levels and elastin content in fetal sheep lungs. American Journal of Physiology (Lung Cell Mol. Physiol.) 284: L643-L649.

Harding R., Cock M. L., Joyce B.J., Louey S., Wignarajah D., Suzuki K., Albuquerque C.A., Maritz G., Wallace M.J. and Hooper S.B. (2003) Immediate and long-term consequences of induced low birthweight in sheep. In: Comparative Neonatology and Perinatology, Havemeyer Foundation Monograph Series No. 8. Eds. P.Sibbons, L. Foster and J.F. Wade.R&W Publications, UK. 29-31.

Loeliger M., Watson C.S., Reynolds J., Penning D.H., Harding R., Bocking A.D., Rees S.M. (2003) Extracellular glutamate levels and neuropathology in cerebral white matter following repeated umbilical cord occlusion in fetal sheep. Neuroscience 116, 705-714.

Parslow P.M., Harding R., Cranage S.M., Adamson T.M. and Horne R.S.C. (2003) Ventilatory responses preceding hypoxia-induced arousal in infants: effects of sleep state. Respiratory Physiology and Neurobiology 136; 235-247.

Loeliger M., Louey S., Cock M.L., Harding R. and Rees S.M. (2003) Chronic placental insufficiency and fetal growth restriction lead to long-term effects on postnatal retinal structure. Clinical and Investigative Ophthalmology 31; 250-253.

Harding R. and Hooper S.B. (2003) Physiologic mechanisms of normal and altered lung growth. In: Fetal and Neonatal Physiology; Third edition, Edited by R. Polin, W. Fox and S. Abman. Published by Elsevier Science (in press)

Harding R., Albuquerque C.A. & Cock M. L. (2003) Role of nutrition in lung development before and after birth. In: The Lung: Development, Aging and the Environment; edited by R. Harding, KE Pinkerton and CG Plopper. Butterworth Heinemann, Oxford (in press)

Hooper S.B. and Harding R. (2003) Pulmonary transition at birth. In: The Lung: Development, Aging and the Environment; edited by R. Harding, KE Pinkerton and CG Plopper. Butterworth Heinemann, Oxford (in press)

Tuladhar R., Harding R., Cranage S.M., Adamson T.M., Horne R.S.C. (2003) Effects of sleep position and sleep state on heart rate responses following arousal in term infants. Early Human Development 71: 157-169.

Dalitz P., Harding R., Rees S.M., Cock M.L. (2003) Prolonged reductions in cerebral blood flow and oxygen in preterm lambs exposed to endotoxin: possible factors in white matter injury after acute endotoxin. Journal of the Society for Gynecologic Investigation 10: 283-290.

Tolcos M., Harding R., Loeliger M., Breen S., Cock M., Duncan J. and Rees S. (2003) The fetal brainstem is relatively spared from injury following intrauterine hypoxemia. Developmental Brain Research 143: 73-81.

Duncan J.R., Cock M.L., Rees S., Harding R. (2003) The effects of repeated endotoxin exposure on placental structure in sheep. Placenta 24; 786-789.

M oss T.J., Nitsos I., Harding R., Newnham J. P. (2003) Differential effects of maternal and fetal betamethasone injections in late gestation fetal sheep. Journal of the Society of Gynecologic Investigation Dec;10(8):474-9

Parslow P.M., Harding R., Cranage S.M., Adamson T.M. and Horne R.S.C. (2003) Arousal responses to somatosensory and mild hypoxic stimuli are depressed during quiet sleep in healthy term infants. Sleep 26(6):739-44.

Flecknoe S.J., Wallace M.J., Cock M.L., Harding R., and Hooper S.B. (2003) Changes in alveolar epithelial cell proportions during fetal and postnatal development in sheep. American Journal of Physiology (Lung Cell Mol Physiol) 285: 664-670.

Moss T.J., Doherty D.A., Nitsos I., Harding R., Newnham J.P. (2003) Pharmacokinetics of betamethasone after maternal or fetal intramuscular administration. American Journal of Obstetrics and Gynecology Dec;189(6):1751-7.