ARC/NHMRC Research Network in Genes and Environment in Development NGED

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Research Funding Provided by:
Australian Government

Research Funding Provided by: Australian Government
Australian Research Council
National Health & Medical Research Council

 

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Network Member Profile

 

Professor Marie Dziadek

Department:
Cancer Research Program

Organisation:
Garvan Institute of Medical Research

Address:
384 Victoria St, Darlinghurst, NSW 2010

Telephone: 02 9295 8195 Facsimile: 02 9295 8101

Email: m.dziadek@garvan.org.au

Web Address

Current Field of Study

  • Epigenetic basis of fetal programming
  • Role of STIM proteins in calcium signalling

Australian Collaborators

  • Professor Julie Owens, Department of Obstetrics and Gynecology, University of Adelaide, Adelaide, SA
  • Associate Professor Mary Wlodek, Department of Physiology, University of Melbourne, Parkville, Victoria

International Collaborators

  • Dr. Lorna Johnstone, School of Biological Sciences, University of Auckland, Auckland, New Zealand
  • Professor Don Gill, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA

Facilities

  • Sequenom mass spectrometer
  • Microarray facility

Lab Members

Prof Marie Dziadek

Head of the Lab

Dr Nasios Fourouclas Postdoctoral Fellow (Nutrition/Epigenetics Project)

Ms Gelina Konycheva

PhD Student

 

Recent Grant Income

Description

CIs

Type of Grant

Year

Income p.a.

Does the prenatal environment influence genomic imprinting during development M Dziadek, B Breier Marsden Fund, NZ Project grant 2002-2005 NZ$207000
The role of STIM transmembrane signalling proteins in regulation of invasive cell behaviour M Dziadek,PJ Smith HRC Project Grant (NZ) 2002-2005 NZ$135000

Recent Publications

Soboloff, J, Spassova MA, Hewavitharana, T, He, L-P, Xu, W, Johnstone, LS, Dziadek, MA, Gill, DL. (2006). STIM1-STIM2 interactions in the control of store-operated Ca2+ entry. Curr Biol. (in press).

Spassova, MA, Soboloff, J, Xu, W, Dziadek, MA, Gill, DL. (2006). STIM1 has a plasma membrane role in the activation of store-operated Ca2+ channels. Proc. Natl. Acad. Sci. (USA) 103: 4040-4045.

Dziadek, M. Genomic imprinting and epigenetic programming of fetal development: In: Perinatal Programming: Early Life Determinants of Adult Health and Disease (Eds DM Hodgson and C Coe). Taylor and Francis Medical Books, London. 2005.

Dziadek, M, Kazenwadel, JS, Hendrey, JA, Pan, T-C, Zhang, R-Z, and Chu, M-L. (2002). Alternative splicing of transcripts for the alpha3 chain of mouse collagen VI: identification of an abundant isoform lacking domains N7-N10 in mouse and human. Matrix Biol. 21: 227-241.

Williams, RT, Senior, PV, Van Stekelenburg, L, Layton, JE, Smith, PJ, and Dziadek, M. (2002). STIM1, a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation. Biochim. Biophys. Acta 1596: 131-137.

Williams, RT, Manji, SSM, Parker, NJ, Hancock, MS, Van Stekelenburg, L, Eid, J-P, Senior, PV, Kazenwadel, JS, Shandala, T, Saint, R, Smith, PJ, and Dziadek, M (2001). Identification and characterization of the STIM gene family: Coding for a novel class of transmembrane proteins. Biochem. J. 357: 673-685.

Martinez, G., Loveland, K.L., Clark, A.T., Dziadek, M., Bertram, J.F. (2001). Expression of BMP receptors in the developing mouse metanephros. Exp. Nephrology 9: 372-79.

Manji, S.S., Parker, N.J., Williams R.T., Van Stekelenburg, L., Pearson, R.B., Dziadek, M., and Smith, P.J. (2000). STIM1: a novel phosphoprotein located at the cell surface. Biochim. Biophys. Acta 1481: 147-55.

Jandeleit-Dahm K, Rumble J, Cox AJ, Kelly DJ, Dziadek M, Cooper E, Gilbert RE. (2000) SPARC gene expression is increased in diabetes-related mesenteric vascular hypertrophy. Microvasc. Res. 59: 61-67.