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Network Member Profile

Current Field of Study

• Identifying molecular mechanisms required for normal heart and placental development in mammals.

Australian Collaborators

• Prof Patrick Tam (Children's Medical Research Institute, Sydney, NSW)
• Dr Paul Thomas (Murdoch Childrens Medical Research Institute, Melbourne, VIC)
• Dr Gerard Hoyne (John Curtin School of Medical Research, Canberra, ACT)
• Prof Richard Harvey (Victor Chang Cardiac Research Institute, Sydney, NSW)
• Prof Emma Whitelaw (University of Sydney, Sydney, NSW)

International Collaborators

• Professor Tim Mohun (National Institute for Medical Research, London, UK)
• Dr Mark de Caestecker (Vanderbilt University, Nashville, USA)
• Dr Kenro Kusumi (National Institute for Medical Research, London, UK)
• Dr Toshi Shioda (MGH Cancer Centre, Charlesworth, USA)
• Prof Hiroshi Hamada (Osaka University, Osaka, Japan)

Facilities

• Microarray facility
• Gene targeting in mouse
• Mouse embryo culture
• Trophoblast stem cell culture
• Notch signaling assay

Recent Publications

Withington SL; Scott A; Saunders D; Lopes Floro K; Preis JI; Michalicek J; Maclean K; Sparrow D; Martinez-Barbera JP; Dunwoodie SL. Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta. Developmental Biology 2006 294(1):67-82.

Genbin Shi, Scott C. Boyle, Duncan B. Sparrow, Sally L. Dunwoodie, Toshi Shioda, and Mark P. de Caestecker. The transcritional activity of Cited1 is regulated by phosphorylation in a cell cycle dependent manner. Journal of Biological Chemistry 2006; 281(37):27426-35.

Sparrow DB, Chapman G, Wouters MA, Whittock NV, Ellard S, Fatkin D, Turnpenny PD, Kusumi K, Sillence D and SL. Dunwoodie (2005) Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. Am J Hum Genet. In press

Plisov S, Tsang M, Shi G, Boyle S, Yoshino K, Dunwoodie SL, Dawid IB, Shioda T, Perantoni AO, de Caestecker MP. (2005) Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning. J Am Soc Nephrol. 2005 Jun;16(6):1632-44.

Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP. (2005) Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart
integrity, function and adaptation. Development. 2005 May;132(10):2451-62.

Wouters MA, Rigoutsos I, Chu CK, Feng LL, Sparrow DB, Dunwoodie SL. (2005) Evolution of distinct EGF domains with specific functions.Protein Sci. 2005 Apr;14(4):1091-103.

Weninger WJ, Floro KL, Bennett MB, Withington SL, Preis JI, Barbera JP, Mohun TJ, Dunwoodie SL. (2005) Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. Development 132, 1337-1348

Kusumi K, Mimoto MS, Covello KL, Beddington RS, Krumlauf R, Dunwoodie SL. (2004) Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes. Genesis. 2004 Jun;39(2):115-21.

Maclean K, Dunwoodie SL. (2004) Breaking symmetry: a clinical overview of left-right patterning. Clin Genet. 2004 Jun;65(6):441-57. Review.

Maclean K, Field MJ, Colley AS, Mowat DR, Sparrow DB, Dunwoodie SL, Kirk EP. (2004) Kousseff syndrome: a causally heterogeneous disorder. Am J Med Genet A. 2004 Jan 30;124(3):307-12.

Raetzman LT, Ross SA, Cook S, Dunwoodie SL, Camper SA, Thomas PQ. (2004) Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression. Dev Biol. 2004 Jan 15;265(2):329-40.

Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, Michalicek J, Clements M, Tsang TE, Shioda T, Beddington RS, Dunwoodie SL. (2004) Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Mol Cell Biol. 2004 Jan;24(1):228-44.

Saunders DN, Hird SL, Withington SL, Dunwoodie SL, Henderson MJ, Biben C, Sutherland RL, Ormandy CJ, Watts CK. (2004) Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion. Mol Cell Biol. 2004 Aug;24(16):7225-34.

Whittock NV, Sparrow DB, Wouters MA, Sillence D, Ellard S, Dunwoodie SL, Turnpenny PD. (2004) Mutated MESP2 causes spondylocostal dysostosis in humans. Am J Hum Genet. 2004 Jun;74(6):1249-54.

Sousa-Nunes R, Rana A, Kettleborough R, Brickman JM, Clements M, Forrest A, Grimmond S, Avner P, Smith JC, Dunwoodie SL and Beddington RSP. (2003) Characterising Embryonic Gene Expression Patterns in the Mouse Using Non-Redundant Sequence-Based Selection. Genome Research 2003; 13(12): 2609-20.

Turnpenny PD, Whittock N, Duncan J, Dunwoodie SL, Kusumi K, Ellard S. (2003) Novel mutations in DLL3, a somitogenesis gene encoding a ligand for the Notch signalling pathway, cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis. Journal of Medical Genetics 2003; 40: 333-339.

Dunwoodie SL*, Beddington RSP. (2002) The expression of Ipl, an imprinted gene, is restricted to extra-embryonic tissues and embryonic lateral mesoderm during early mouse development. International Journal of Developmental Biology 2002; 46(4):459-466. (*Corresponding author) [Journal Impact Factor 2.982]

Dunwoodie SL*, Clements M, Sparrow DB, Sa X, Conlon RA, Beddington RSP. (2002) Axial skeletal defects caused by mutation in the spondylocostal dysostosis/pudgy gene D113 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development 2002; 129:1795-1806. (*Corresponding author) [Journal Impact Factor 9.353]

Martinez Barbera JP, Rodriguez TA, Greene N, Weniger WJ, Simeone A, Copp A, Beddington RSP, Dunwoodie SL. (2002) Administration of folic acid prevents exencephaly in Cited2 deficient mice. Human Molecular Genetics 2002; 11(3):283-293. [Journal Impact Factor 9.048]

Sparrow DB, Clements M, Withington SL, Scott AN, Novotny J, Sillence D, Kusumi K, Beddington RSP, Dunwoodie SL. (2002) Diverse requirement for notch signalling in mammals. International Journal of Developmental Biology 2002; 46(4):365-374. [Journal Impact Factor 2.982]

Yahata T, Takedatsu H, Dunwoodie SL, Braganca J, Swingler T, Withington SL, Hur J, Coser KR, Isselbacher KJ, Bhattacharya S, Shioda T. (2002) Cloning of mouse cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells. Genomics 2002 Dec; 80(6):601-13.