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Network Member Profile

Current Field of Study

• Developmental Biology
• Cancer
• Diabetes
• Fertility
• Gastroenterology
• Hearing and Deafness
• Infection and Immunity e.g. Systemic Lupus Erythematosus, Multiple Sclerosis
• Lactation
• Malocclusion
• Neuromuscular Deficits
• Obesity
• Sex Determination

Facilities / Services

The APF provides expertise and services to your advance your research programme through:

• Access to gene-variant strains that serve as unique animal models of human disease.
• Access to large-scale collections of ENU gene-variant libraries for detection of recessive mutations.
• Production of new mouse strains with researcher-specified phenotypes.
• Expertise in screen and library design, phenotyping equipment and pathological analysis.
• Expertise in project management.
• Access to electronic data management and project tracking.
• Access to mapping and resequencing expertise to coordinate and interpret initial genome scan, perform fine mapping, candidate gene resequencing.
• Risk management, cryopreservation, quarantine and rederivation services to defined flora free health status.
• Access to the NH&MRC Australian Phenome Bank services.
• Access to mouse holding space.
• Participation in Federation of International Mouse Resources consortium, integration and leveraging international resources and best practice.
• Consortium and collaborative approach to assist in winning new grants.
• Flexible IP policy: including open access (free access to any results), own outcome (subject to payment of full rate) and joint ownership with ANU (proportions to be agreed).
• Training for scientific and technical staff.
• Specific facilities that we offer include:
  o 12-parameter flow cytometer
  o Clinical biochemistry, Olympus AU400 autoanalyser
  o Affymetrix and spotted microarray gene expression profiling
  o ABI 4800 MALDI-TOF plus 2d LC and Accuspot
  o ABI 7900 real time PCR

Australian Collaborators (Institutions)

• Animal Resources Centre, Perth
• Australian Genome Research Facility
• Australian National University
• Bio21 Institute
• Institute for Medical and Veterinary Sciences
• The Institute for Molecular Bioscience
• The Garvan Institute of Medical ResearchMonash Institute of Medical Research
• Monash University
• Murdoch Children's Research Institute
• Prince Henry's Institute
• Queensland Brain Institute
• Queensland Institute of Medical Research
• University of Adelaide
• University of Melbourne
• University of Tasmania
• Walter and Eliza Hall Institute
  

International Collaborators (Academic)

• Federation of International Mouse Repositories (FIMRe)
• North American Conditional Mouse Mutagenesis Project (NorCOMM)
• China (Institute of Biophysics, Beijing)
• Singapore (The Singapore Agency for Science Technology and Research)
• UK (University of Oxford)
• USA (University of California, San Francisco; Scripps Research Institute; Genome Institute of the Novartis Foundation; Baylor College of Medicine, Texas)
  

Selected Publications arising from work at the APF:

Hoyne GF, Goodnow, CC. (2006) The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity. Immunological Reviews 210:27-39.

Kennedy CL, O'Connor AEO, Sanchez-Partida, LG, Holland,MK, Goodnow CC, de Kretser DM, O'Bryan MK. (2006) A repository of ENU mutant mouse lines and their potential for male fertility research. Molecular Human Reproduction 11:871-880.

Kennedy C. and Moira O'Bryan. (2006) ENU mutagenesis and fertility research. Human Reproduction Update 12:293-301.

Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L, Hill KM, Yu D, Domaschenz H, Whittle B, Lambe T, Roberts IS, Copley RR, Bell JI, Cornall RJ, Goodnow CC. (2005) A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435:452-458.
Papathanasiou P, Goodnow CC. (2005) Connecting mammalian genome with phenome by ENU mouse mutagenesis: Gene combinations specifying the immune system. Annual Review of Genetics 39:241-262.

Jun JE, Wilson LE, Vinuesa CG, Lesage S, Blery M, Miosge LA, Cook MC, Kucharska EM, Hara H, Penninger JM, Domashenz H, Hong NA, Glynne RJ, Nelms KA, Goodnow CC. (2003) Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 18:751-62.

Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale ST, Goodnow CC. (2003) Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity 19:131-44.