Network Member Profile
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Professor John F. Bertram
Department: Department of Anatomy and Cell Biology
Organisation: Monash University
Address: Clayton, VIC 3800
Telephone: 03 9905 2751 Facsimile:
03 9905 2766
Email: John.Bertram@med.monash.edu.au
Web
Address
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Current Field of Study
- Fetal development, nephron endowment and renal disease in adulthood
- Kidney developmental biology
- Renal stem cells and renal regeneration
Australian Collaborators
- A/Prof Melissa Little, Institute of Molecular Bioscience, UQ, Brisbane,
Qld
- Dr. Sean Grimmond, Institute of Molecular Bioscience, UQ, Brisbane, Qld
- Prof Julie Campbell, Institute of Molecular Bioscience, UQ, Brisbane, Qld
- Prof Gordon Campbell, Institute of Molecular Bioscience, UQ, Brisbane,
Qld
- Prof Wendy Hoy, Centre for Chronic Diseases, School of Medicine, UQ, Brisbane,
Qld
- Dr. Andrew Perkins, Institute of Molecular Bioscience, UQ, Brisbane, Qld
- Dr Michelle Kett, Dept of Physiology, Monash University, Clayton, Vic
- Dr. Roger Evans. Dept of Physiology, Monash University, Clayton, Vic
- Dr. Sharyn Fitzgerald, Dept of Physiology, Monash University, Clayton,
Vic
- Prof Gail Risbridger, Monash Institute of Reproduction and Development,
Monash University, Clayton, Vic
- Dr. Jane Black, Dept of Anatomy and Cell Biology, Monash University, Clayton,
Vic
- Dr. Ian Harper, Dept of Anatomy and Cell Biology, Monash University, Clayton,
Vic
- Dr Karen Gibson, Dept of Physiology and Pharmacology, University of NSW,
Sydney, NSW
International Collaborators
- Dr. Michael Hughson, The University of Mississippi, USA
- Dr. Normal Rosenblum, University of Toronto, Canada
- Dr. Dominique Jeulin, CMM, ENSMP, France
- Dr. Frank Costantini of Columbia University, USA
- Dr Carlton Bates, Columbus Children's Research Institute, Columbus, Ohio,
USA
Facilities
- Monash MicroImaging – 5 confocals, 4 TEMs and 1 SEM
- Structural Biology Facility with mass spec
- Monash Mouseworks – facility for generating and breeding transgenic and knockout mice
- Stereology Facility – facility for quantifying organ, tissue and cellular structure using unbiased stereological methods
Lab Members
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| Prof John Bertram |
Head of the Lab |
| Dr Stephen Bird |
Project Officer 'Healthy Start to Life' |
| Dr Georgina Caruana |
Postdoctoral Fellow |
| Dr Jinhua Li |
Postdoctoral Fellow |
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Dr Monika Zimanyi
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Postdoctoral Fellow
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| Mr Terence Samuel |
PhD Student |
| Ms Chantal Hoppe |
PhD Student |
| Ms Bridgette McNamara |
PhD Student |
| Ms Reetu Singh |
PhD Student |
| Mr Stephen Gray |
PhD Student |
| Mr Ken Walker |
Honours Student |
| Ms Sarah Henry |
Honours Student 2007 |
| Mr Ryan Wood-Bradley |
Honours Student 2007 |
| Cissy Yu |
Honours Student 2007 |
| Ms Rebecca Douglas-Denton |
Research Assistant |
| Ms Debbie Arena |
Research Assistant |
Recent Grant Income
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Description
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CIs
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Type of Grant
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Year
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Income p.a.
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| The effects of pre-term birth on the baboon and
human neonatal kidney. |
Black M.J., Bertram J.F, Robinson, J. Coalson,
L. Moore, M. Stahlman. |
NHMRC Project Grant. |
2007-2009 |
112,000 |
| 3D atlas and database of murine urogenital development |
Davidson D.R., Baldock R.A., Bertram J.F., Davies J.A.,
Fitzpatrick D.R., Hastie N.N. and Yang Y. |
NIH NIDDK |
2005-2009 |
US$ $2,566,232 |
| Exploring the physiological, morphological and molecular
bases of renal developmental programming. |
Bertram, J.F., K. Moritz, R.E. Evans and S. Grimmond. |
NH&MRC Project
Grant. |
2006-2008 |
138,000 |
| Towards renal regeneration: isolation, characterization
and functional analysis of renal stem cells |
Bertram J.F., M.H. Little, G. Campbell, J. Campbell, D.
Hume, S.D. Ricardo, W. Anderson, D. Alcorn, G. Caruana, M. Falk, S. Grimmond,
M. Pera, A. Perkins, and R. Teasdale |
Australian Kidney Foundation Bootle Bequest Grant |
2003-2007 |
$1.5 million over 5 years |
| Nephron count, birth weight and hypertensive renal disease |
Hughson M.D., W.E. Hoy, J.F. Bertram |
NIH NIDDK |
2004-2007 |
US$664,038 |
Recent Publications
Shweta A, Denton KM, Kett MM, Bertram JF, Lambert GW, Anderson WP. Paradoxical
structural effects in the unilaterally denervated spontaneously hypertensive
rat kidney. J Hypertens. 23(4):851-9, 2005.
Almahbobi G., S. Hedwards, G. Fricout, D. Jeulin, J.F. BERTRAM and G.P. Risbridger.
Computer-based detection of neonatal changes to branching morphogenesis reveals
different mechanisms of and predicts prostate enlargement in adulthood. J. Pathology.
206(1):52-61, 2005.
Cullen-McEwen L., R.J. Young, G. Fricout, D. Jeulin, I.S. Harper, F. Costantini
and J.F. BERTRAM. Imaging tools for analysis of the ureteric tree in the developing
mouse kidney. In: Paddock S.W. (ed). Confocal Microscopy. Methods and Protocols.
2 nd edition. Methods in Molecular Biology Series. Humana Press. (in press;
accepted 3/2004).
Cain J.E., T. Nion, D. Jeulin and J.F. BERTRAM. Exogenous BMP-4 amplifies
asymmetric ureteric branching in the developing mouse kidney in vitro. Kidney
Int. 67: 420-431, 2005.
Cullen-McEwen L., G. Caruana and J.F. BERTRAM. The where, what and why of
the developing renal stroma. Nephron: Exptl. Nephrol. (Invited review) 99:e1-e8,
2005.
Zimanyi MA, Bertram JF, Black MJ. Does a nephron deficit in rats predispose
to salt-sensitive hypertension? Kidney Blood Press Res. 27:239-247, 2004.
Bruce KM, Narayan K, Kong HC, Larmour I, Lopes EC, Turner BJ, Bertram JF,
Cheema SS. Chemotherapy delays progression of motor neuron disease in the SOD1
G93A transgenic mouse. Chemotherapy 50:138-142, 2004.
Jenkins M.S., Wong K.C., Chhit O., BERTRAM J.F., Young R.J., Subaschandar
N. Quartz crystal microbalance based measurements of shear induced senescence
in human embryonic kidney cells. Biotechnol Bioeng. 88:392-398, 2004.
Kett M.M. and J.F. BERTRAM. Nephron number and blood pressure – what
do we really know? (Invited review). Curr. Hypertens Rep. 6:133 - 139, 2004.
Dilley R.J., B. Rizkalla and J.F. BERTRAM. Cardiovascular hypertrophy in one-kidney,
one-clip renal hypertension is resistant to heparin. J. Hypertension 22:767-774,
2004.
Black M.J., T.A. Briscoe, M. Constantinou, M.M. Kett and J.F. Bertram. Is
there an association between level of adult blood pressure and nephron number
or renal filtration surface area? Kidney Int. 65: 582-588, 2004.
Samuel, T., R. Douglas-Denton, W.E. Hoy, M. Hughson, M. Little and J.F. BERTRAM.
Nephron endowment and potential therapies for nephron deficit. Today’s
Life Science 15:30-33, 2003.
Hughson, M., A.B. Farris III, R. Douglas-Denton, W.E. Hoy and J.F. BERTRAM.
Glomerular number and size in autopsy kidneys: the relationship to birth weight.
Kidney Int. 63:2113-2122, 2003.
Cullen-McEwen, L.A., M.M. Kett, W.P. Anderson and J.F. Bertram. Nephron number,
renal function and arterial pressure in aged GDNF heterozygous mice. Hypertension
41:335-340, 2003.
Hoy W.E., M. Hughson, A. Cass, K. Johnson, R. Douglas-Denton and J.F. BERTRAM.
A stereological study of glomerular number and volume: preliminary studies in
a multiracial study of kidneys at autopsy. Kidney Int. 63 (Suppl 83): S31-S37,
2003.
Martinez G. and J.F. BERTRAM. Organisation of BMPs in renal development (invited
review). Nephron: Exptl. Nephrol. 93:e18-e22, 2003.
Dunstan H.J., T.A. Briscoe, J.F. BERTRAM, C.I. Johnston and M.J. Black. Angiotensin-converting
enzyme inhibition in adult hypertensive rats: a stereological study of renal
filtration surface area. Clin. Exptl. Pharm. Physiol. 30:72-76, 2003.
Brown J., T.A. Briscoe, R. Harding, M. Cock, J.F. BERTRAM, M.J. Black. Glomerular
number and capillary dimensions in the normal lamb kidney. Image Anal. Stereol.
21: 157-164, 2002.
Cullen-McEwen L.A., G. Fricout, I.S. Harper, D. Jeulin and J.F. BERTRAM. Quantitation
of 3D ureteric branching morphogenesis in cultured embryonic mouse kidney. Int.
J. Dev. Biol. 46:1049-1055, 2002.
Zimanyi, M.A., J.F. BERTRAM and M.J. Black. Nephron number and blood pressure
in rat offspring with maternal high-protein diet. Pediatr. Nephrol. 17:1000-1004,
2002.
Hood JC, Dowling J, BERTRAM JF, Young RJ, Huxtable C, Robinson W, Savige.
Correlation of histopathological features and renal impairment in autosomal
dominant Alport syndrome in Bull terriers. J. Nephrol. Dial. Transplant. 17:1897-1908,
2002.
Hoy W.E., S. McDonald, A. Cass, G. Singh, P. Baker, J. You, A. White, J.F.
BERTRAM, M.D. Hughson, R. Douglas-Denton, A. Farris and Z. Wang. A broader view
of renal disease: findings in Aboriginal Australia. Recent Advances in Microbiology,
ch. 5, pp 75-96, 2002.
Xu, K.F., R. Vlahos, A. Messina, T.L. Bamford, J.F. BERTRAM and A.G. Stewart.
Antigen-induced airway inflammation in the Brown Norway rat results in airway
smooth muscle hyperplasia. J. Appl. Physiol. 93: 1833-1840, 2002.
Fricout, G., D. Jeulin, L.A. Cullen-McEwen, I.S. Harper and J.F. BERTRAM.
3D-skeletonization of ureteric trees in developing kidneys. In: “Mathematical
Morphology: Proceedings of the V1th International Symposium ISSM 2002”.
Ed. By H. Talbot and R Beare. CSIRO Publishing, Collingwood, pp. 157-164, 2002.
L.S. Gambino, N.G. Wreford, J.F. BERTRAM, P. Dockery, F. Lederman and P.A.W.
Rogers. Angiogenesis occurs by vessel elongation in proliferative phase human
endometrium. Hum. Reprod. 17: 1199-1206, 2002.
Martinez G., Mishina Y. and BERTRAM J.F. BMPs and BMP receptors in mouse metanephric
development: in vivo and in vitro studies. Int. J. Dev. Biol.
46: 525-533, 2002.
Hughson M.D., K. Johnson, R.J. Young, W.E. Hoy and J.F. BERTRAM. Glomerular
size and glomerulosclerosis: Relationships to disease categories, glomerular
solidification, and ischemic obsolescence. Am. J. Kidney Dis. 39: 679-688, 2002.
Douglas-Denton R., K. Moritz, J.F. BERTRAM and E.M. Wintour. Compensatory
renal growth after unilateral nephrectomy in the ovine fetus. J. Am. Soc. Nephrol.
13: 406-410, 2002.
Black M.J., Y. Wang and J.F. BERTRAM. Nephron endowment and renal filtration
surface area in young spontaneously hypertensive rats. Kidney Blood Press. Res.
25: 20-26, 2002.
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