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Network Member Profile

Current Field of Study

• Mammalian Developmental Genetics

International Collaborators

• Ioannis Ragoussis, The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, UK.
• Jonathan Flint, The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, UK.
• Thomas Zwaka, Baylor College of Medicine, Department of Molecular and Cellular Biology, Center for Cell and Gene Therapy, Houston, TX, USA.
• Kathy Millen, Department of Human Genetics, University of Chicago, Chicago, Illinois, USA.
• Pat Nolan, Mammalian Genetics Unit, MRC Harwell, Oxfordshire, UK.
• Dominic Norris, Mammalian Genetics Unit, MRC Harwell, Oxfordshire, UK.
• Kate Barald, Department of Cell and Developmental Biology , University of Michigan Medical School, Ann Arbor, MI, USA.
• Steve Brown, University of Vermont, Burlington, VT , USA.

Facilities

Recent Publications

Garrick, D., Sharpe, J., Arkell, R.M., Dobbie, L., Smith, A., Wood, B., Higgs, D., and Gibbons, R. Targeted disruption of the SNF2-like protein Atrx causes trophoblast failure and embryonic lethality. (2006) PLoS Genet. 2(4): e58.

Bogani, D., Willoughby, C., Davies, J., Kaur, K., Mirza, G., Paudyal, A., Haines, H., McKeone, R., Cadman, M., Pieles, G., Schneider, J.E., Bhattacharya, S., Hardy, A., Nolan, P.M., Tripodis, N., Depew, M.J., Chandrasekara, R., Duncan, G., Sharpe, P.T., Greenfield, A., Denny, P., Brown, S.D.M., Ragoussis, J. and Arkell, R. Dissecting the genetic complexity of human 6p deletion syndromes using a region-specific, phenotype-driven mouse screen. (2005) Proc Natl Acad Sci U S A, 102(35): 12477-12482.

Blewitt, M.E., Vickaryous, N.K., Hemley, S.J., Ashe, A., Bruxner, T.J., Preis, J.I., Arkell, R. and Whitelaw, E. An ENU screen for genes involved in variegation in the mouse. (2005) Proc Natl Acad Sci U S A. 102(21):7629-34.

Brown, L., Paraso, M., Arkell, R. and Brown, S. In vitro analysis of partial loss-of-function ZIC2 mutations in holoprosencephaly: alanine tract expansion modulates DNA binding and transactivation. (2005) Hum. Mol. Genet.14(3):411-20.

Bogani, D., Warr, N., Elms, P., Davies, J., Tymowska-Lalanne, Z., Goldsworthy, M., Cox, R.D., Keays, D.A., Flint, J., Wilson, V., Nolan, P. and Arkell, R. New semidominant mutations that affect mouse development. (2004) Genesis 40(2):109-117.

Mallon, A-M., Wilming, L., Weekes, J., Gilbert, J.G.R., Ashurst, J., Peyrefitte, L., Matthews, L., Cadman, M., McKeone, R., Sellick, C., Arkell, R., Botcherby, M.R.M., Strivens, M.A., Campbell, R.D., Gregory, S., Denny, P., Hancock, J.M., Rogers, J. and Brown, S.D.M. Organization and evolution of a gene-rich region of the mouse genome: a 12.7 Mb region deleted in the Del(13)Svea36H mouse. (2004) Genome Research 14(10):1888-1901.

Elms, P., Scurry, A., Davies, J., Willoughby, C., Hacker, T., Bogani, D. and Arkell, R. Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation. (2004) Gene Expr. Patterns 4(5):505-511.

Elms, P., Siggers, P., Napper, D., Greenfield, A. and Arkell, R. Zic2 is required for neural crest formation and hindbrain patterning during mouse development. (2003) Dev. Biol. 264:391-406.

Curtin, J.A., Quint, E., Tsipouri, V., Arkell, R.M., Cattanach, B., Copp, A.J., Henderson, D.J., Spurr, N., Stanier, P., Fisher, E.M., Nolan, P.M., Steel, K.P., Brown, S.D., Gray, I.C. and Murdoch, J.N. Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. (2003) Curr. Biol. 13(13):1129-1133.

Murdoch, J.N., Henderson, D.J., Doudney, K., Gaston-Massuet, C., Phillips, H.M., Paternotte, C., Arkell, R., Stanier, P. and Copp, AJ. Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. (2003) Hum. Mol. Genet. 12(2):87-98.

Arkell, R.M., Cadman, M., Marsland, T., Southwell, A., Thaung, C., Davies, J.R., Clay, T., Beechey, C., Evans, E.P., Strivens, M.A., Brown, S.D.M. and Denny, P. Genetic, physical and phenotypic characterisation of the Del(13)Svea36H mouse mutant. (2001) Mammalian Genome 12:687-694.

Grimmond, S., Larder, R., Van Hateren, N., Siggers, P., Morse, S., Thacker, T., Arkell, R. and Greenfield, A. Expression of a novel mammalian EGF-related gene during mouse neural development. (2001) Mech. Dev. 102(1-2):209-211.

Episkopou, V., Swan, D., Timmons, P., Walsh, J., Andrew, R. and Arkell, R. Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. (2001) Nature 410:825-30.

Grimmond, S., Larder, R., Van Hateren, N., Siggers, P., Hulsebos, T.J., Arkell, R. and Greenfield, A. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). (2000) Genomics 70(1):74-81.

Grimmond, S., Van Hateren, N., Siggers, P., Arkell, R., Larder, R., Soares, MB., de Fatima Bonaldo, M., Smith, L., Tymowska-Lalanne, Z., Wells, C. and Greenfield, A. Sexually dimorphic expression of protease nexin-1 and Vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development. (2000) Hum. Mol. Genet. 9(10):1553-1560.

Nolan, P.M., Peters, J., Strivens, M., Rogers, D., Hagan, J., Spurr, N., Gray, I.C., Vizor, L., Brooker, D., Whitehill, E., Washbourne, R., Hough, T., Greenaway, S., Hewitt, M., Liu, X., McCormack, S., Pickford, K., Selley, R., Wells, C., Tymowska-Lalanne, Z., Roby, P., Glenister, P., Thornton, C., Thaung, C., Stevenson, J-A., Arkell, R., Mburu, P., Hardisty, R., Kiernan, A., Erven, A., Steel, K.P., Voegeling, S., Guenet, J-L., Nickols, C., Sadri, R., Naase, M., Isaacs, A., Davies, K., Browne, M., Fisher, E.M.C., Martin, J., Rastan, S., Brown, S.D.M. and Hunter, J. A systematic genome-wide phenotype-driven mutagenesis programme for gene function studies in the mouse (2000) Nature Genetics 25(4):440-443.